1

張元慶

教授

研究領域：高通量微流控芯片用于液體活檢和單細胞分析；框架核酸材料在分析方法學中的應用；多功能納米材料用于癌症的診斷和治療

辦公電話： 太阳集团1088vip323室

聯系郵箱： zhangyq65@mail.sysu.edu.cn

聯系方式

電子郵箱：zhangyq65@mail.sysu.edu.cn

辦公地址：太阳集团1088vip323室

簡單介紹

張元慶教授，博導，長期從事微流控芯片和框架核酸材料在癌症轉移、液體活檢等領域的基礎和應用研究。其科研成果以通訊作者身份在Angewandte Chemie International Edition、Journal  of  the  American  Chemical  Society、Nano  Letters和Advanced Science等期刊上發表多篇高水平論文。

研究方向

高通量微流控芯片用于液體活檢和單細胞分析；框架核酸材料在分析方法學中的應用；多功能納米材料用于癌症的診斷和治療。

教育經曆

2006.09 - 2011.06 中國科學院上海應用物理所 博士

2000.09 - 2004.07 中國科學技術大學 學士

工作經曆

2015.10 - 至今   太阳集团1088vip教授

2011.07 - 2015.10 美國康奈爾大學醫學院HMRI博士後

教學情況

《分析化學》《基礎化學》《大學化學實驗二》等 本科生課程

《藥物儀器分析》 研究生課程

社會/學術任職

《藥學學報》青年編委 第二屆

廣東省藥學會生物醫藥分析專業委員會副主任委員

中國微米納米技術學會微納流控技術分會理事會理事

科研項目

廣東省自然科學基金 面上項目 2024-2026

國家自然科學基金 面上項目 2021-2024；

廣東省自然科學基金 傑出青年項目 2017-2021;

國家自然科學基金 青年項目 2017-2019；

中山大學“百人計劃二期”啟動項目 2015-2017；

中山大學青年教師重點培育計劃 2016-2017；

中山大學重大項目培育和新興、交叉學科資助計劃 2017-2018;

其他與企業合作的橫向項目等。

論著專利

代表性論文：

  1. Dongdong Zhu, Xiaocao Ma, Jingguo Wang, Tiantian Chen, Jiahui Yang, Yan Liu, Zhun Lin, Minhao Wu*, Tony Y. Hu*,  Yuanqing Zhang*. A Sequential Release Micro-nano System for Colitis Therapy via Gut Microbiota and Immune Regulation. Angewandte Chemie International Edition2025, DOI：10.1002/anie.202424409
  2. Jingguo Wang, Siping Liang, Dongdong Zhu, Xiaocao Ma, Qin Peng, Guanzhao Wang, Yuting Wang, Tiantian Chen, Minhao Wu*, Tony Y Hu*, Yuanqing Zhang*. Valence-Change MnO2-coated Arsenene Nanosheets as Pin1 Inhibitor for Hepatocellular Carcinoma Treatment. Journal of the American Chemical Society;2024; 146, 21568−21582
  3. Miao Mao, Zhun Lin,  Liang Chen, Zhengyu Zou, Jie Zhang, Quanhao Dou, Jiacheng Wu, Jinglin Chen, Minhao Wu, Li Niu,  Chunhai Fan, Yuanqing Zhang*. Modular DNA-Origami-Based Nanoarrays Enhanced Cell Binding-Affinity through “Lock-and-Key” Interaction. Journal of the American Chemical Society;2023;  145, 9, 5447–5455
  4. Jiacheng Wu, Zhun Lin, Zhengyu Zou, Siping Liang, Minhao Wu*, Tony Y Hu*, Yuanqing Zhang*. Identifying the Phenotypes of Tumor-Derived Extracellular Vesicles using Size-coded Affinity Microbeads. Journal of the American Chemical Society;2022; 144, 51, 23483–23491
  5. Zhun Lin,Jie Zhang,Zhengyu Zou,Gen Lu,Minhao Wu*,Li Niu*,Yuanqing Zhang*. A Dual-Encoded Bead-Based Immunoassay with Tunable Detection Range for COVID-19 Serum Evaluation. Angewandte Chemie International Edition 2022, 61(37), e202203706 

其他論文：

  1. Peng Zhang, Jinxiu Han, Xue Kong, Shaojun Liu, Yuqing Chen, Juan Li, Yuanqing Zhang*, Chuanxin Wang*, Lutao Du*. Biomimetic Synthesis of Nanomachine Inspired from Neutrophil Extracellular Traps for Multi-modal Antibacterial Application. ACS Nano.2025. ASAP
  2. Zhun Lin, Siping Liang, Zhe Pu, Zhengyu Zou, Luxuan He, Christopher J. Lyon, Yuanqing Zhang*,Tony Y. Hu*, Minhao Wu*. Phenotypic plasticity and secretory heterogeneity in subpopulations derived from single cancer cell. Acta Pharmaceutica Sinica B. 2025. ASAP
  3. Yuyuan Zhang, Xiaojie Qin, Zhanyu Xu, Weifeng Liu, Hao Lu, Yu Yang, Jie Yang, Xinchun Li, Yuanqing Zhang*, Fan Yang*. Electric Field-Resistant Bubble-Enhanced Wash-Free Profiling of Extracellular Vesicle Surface Markers.  ACS Nano.2025. ASAP
  4. Jie Zhang, Jiacheng Wu, Guanzhao Wang, Luxuan He, Ziwei Zheng, Minhao Wu, Yuanqing Zhang*. Extracellular Vesicles: Techniques and Biomedical Applications Related to Single Vesicle Analysis. ACS Nano.2023 Sep 26;17(18):17668-17698.
  5. Jie Zhang, Liwen Wei, Xiaocao Ma, Jingguo Wang, Siping Liang, Kang Chen, Minhao Wu, Li Niu, Yuanqing Zhang*. pH-sensitive tumor-tropism hybrid membrane-coated nanoparticles for reprogramming the tumor microenvironment and boosting the antitumor immunity. Acta Biomater .2023 166:470-484.
  6. Zhengyu Zou, Zhun Lin, Chenglin Wu, Jizhou Tan, Jie Zhang, Yanwen Peng, Kunsong Zhang, Jiaping Li, Minhao Wu*, Yuanqing Zhang*. Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients. Advanced Science2023 Sep;10(27):e2302640. doi: 10.1002/advs.202302640.
  7. Zhun Lin, Zhengyu Zou, Zhe Pu, Minhao Wu*,Yuanqing Zhang*.  Application of Microfluidic Technologies on COVID-19 Diagnosis and Drug Discovery.Acta Pharmaceutica Sinica B. 2023; 13(7):2877-2896. 
  8. Jizhou Tan, Ting Liu, Wenzhe Fan, Jialiang Wei, Bowen Zhu, Yafang Liu, Lingwei Liu, Xiaokai Zhang, Songling Chen, Haibiao Linc, Yuanqing Zhang*, Jiaping Li*. Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma. Acta Pharmaceutica Sinica B. 2023; 13(2), 632-647
  9. Liang Chen, Shihua Luo, Zhilei Ge, Chunhai Fan, Yang Yang*, Qian Li*,  Yuanqing Zhang*. Unbiased Enrichment of Circulating Tumor Cells via DNAzyme Catalyzed Proximal Protein Biotinylation. Nano Letters.2022, 22, 4, 1618–1625.
  10. Lingwei Liu, Jialang Zhuang, Jizhou Tan, Ting Liu, Wenzhe Fan, Yuanqing Zhang*, and Jiaping Li*. Doxorubicin-Loaded UiO-66/Bi2S3 Nanocomposite-Enhanced Synergistic Transarterial Chemoembolization and Photothermal Therapy against Hepatocellular Carcinoma. ACS Applied Materials & Interfaces. 2022, 14, 6, 7579–7591.
  11. Yan Liu, Zhun Lin, Ziwei Zheng, Yuanqing Zhang*, Lingling Shui*.  Accurate Isolation of Circulating Tumor Cells via a Heterovalent DNA Framework Recognition Element Functionalized Microfluidic Chip. ACS Sensors. 2022, 7, 2, 666–673.
  12. Siping Liang,  Jiaying Li, Zhengyu Zou, Miao Mao, Siqi Ming, Fan Lin, Ziyan Zhang, Can Cao, Jinyu Zhou, Yuanqing Zhang*, Jiaping Li *, Minhao Wu*. Tetrahedral DNA Nanostructures Synergize with MnO2 to Enhance Antitumor Immunity via Promoting STING Activation and M1 Polarization. Acta Pharmaceutica Sinica B. 2022; 12(5), 2494-2505.
  13. Liang Chen, Jie Zhang, Zhun Lin, Ziyan Zhang, Miao Mao, Jiacheng Wu, Qian Li, Yuanqing Zhang*, Chunhai Fan*. Pharmaceutical applications of framework nucleic acids. Acta Pharmaceutica Sinica B. 2022; 12(1), 76-91. Invited Review
  14. Ziyan Zhang, Qiaojuan Liu, Jizhou Tan, Xiaoxia Zhan, Ting Liu, Yuting Wang, Gen Lu*, Minhao Wu*, Yuanqing Zhang*. Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy. Acta Pharmaceutica Sinica B. 2021;11, 1965-1977.(Cover story)
  15. Fan Lin, Yong Shao, Yingjie Wu, Yuanqing Zhang*. NIR light-Propelled Janus-Based Nanoplatform for Cytosolic-Fueled MicroRNA Imaging. ACS  Appl. Mater. Interfaces. 2021; 13(3), 3713-3721.
  16. Weiwei Qin, Liang Chen, Zhiru Wang, Qian Li*, Chunhai Fan, Minhao Wu, Yuanqing Zhang*. Bioinspired DNA Nanointerface with Anisotropic Aptamers for Accurate Capture of Circulating Tumor Cells. Advanced Science. 2020;DOI: 10.1002/advs.202000647.
  17. Liang Chen, Siping Liang, Yu Chen, Minhao Wu*, Yuanqing Zhang*. Destructing the Plasma Membrane with Activatable Vesicular DNA Nanopores. ACS  Appl. Mater. Interfaces. 2020;12, 1: 96-105.
  18. Jialang Zhuang, Jizhou Tan, Chenglin Wu, Jie Zhang, Ting Liu, Chunhai Fan, Jiaping Li*, Yuanqing Zhang*. Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy. Nucleic Acids Research, 2020, 48(16)，8870-8882.
  19. Yubing Liu, Dabin Chen, Weiqiong Zhang, Yuanqing Zhang*. Mobile DNA tetrahedron on ultra-low adsorption lipid membrane for directional control of cell sensing. Sensors and Actuators B: Chemical.2020; 307, 127570.
  20. Jialang Zhuang, Jie Zhang, Minhao Wu, Yuanqing Zhang* A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation. Advanced Science. 2019; DOI: 10.1002/advs.201901462
  21. Zhiru Wang, Weiwei Qin*, Jialang Zhuang, Minhao Wu, Qian Li, Chunhai Fan*, Yuanqing Zhang*. Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws. ACS  Appl. Mater. Interfaces. 2019; 11: 12244–12252.
  22. Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang*, Yuanqing Zhang*. Multifunctional MoS2 nanosheets with Au NPs grown in situ for synergistic chemo-photothermal therapy. Colloids and Surfaces B: Biointerfaces2019; 184, 110510.
  23. Ke Wang, Xi Liu, Jialang Zhuang, Yubing Liu, Maosheng Xu, Dong Xie, Junjia Chen*, Xiaoyong Zhang, Yen Wei, Yuanqing Zhang*. Small fluorescent albumin nanoparticles for targeted photothermal therapy via albumin-Binding protein pathways. Colloids and Surfaces B: Biointerfaces2019; 181,696-704.
  24. Jialang Zhuang, Yongjian Wu, Liang Chen, Siping Liang, Minhao Wu, Ledu Zhou, Chunhai Fan, Yuanqing Zhang*. Single‐Cell Mobility Analysis of Metastatic Breast Cancer Cells. Advanced Science. 2018；DOI: 10.1002/advs.201801158.
  25. Dabin Chen, Duanping Sun, Zhiru Wang, Weiwei Qin, Liang Chen, Ledu Zhou, Yuanqing Zhang*. A DNA nanostructured aptasensor for the sensitive electrochemical detection of HepG2 cells based on multibranched hybridization chain reaction amplification strategy.  Biosensors and Bioelectronics.2018; 117:416-421.
  26. Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang*, Minhao Wu*. The application of CAR-T cell therapy in hematological malignancies: Advantages and challenges. Acta Pharmaceutica Sinica B. 2018; 8; 539-551.
  27. Duanping Sun, Jing Lu, Dabin Chen, Yunfei Jiang, Zhiru Wang, Weiwei Qin, Yanyan Yu, Zuanguang Chen,Yuanqing Zhang*. Label-free electrochemical detection of HepG2 tumor cells with a self-assembled DNA nanostructure-based aptasensor. Sensors and Actuators B: Chemical.2018; 268:359-367.
  28. Yunfei Jiang, Duanping Sun, Zhixian Liang, Liang Chen, Yuanqing Zhang*, Zuanguang Chen*. Label-free and competitive aptamer cytosensor based on layer-by-layer assembly of DNA-platinum nanoparticles for ultrasensitive determination of tumor cells. Sensors and Actuators B: Chemical. 2018; 262:35-43.
  29. Ke Wang, Jialang Zhuang, Yubing Liu, Maosheng Xu, Jingyuan Zhuang, Zuanguang Chen, Yen Wei, Yuanqing Zhang*. PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and photothermal therapy. Carbohydrate Polymers. 2018; 184:445-452.
  30. Ke Wang, Jialang Zhuang, Liang Chen, Dazhuang Xu, Xiaoyong Zhang, Zuanguang Chen, Yen Wei, Yuanqing Zhang*. One-pot synthesis of AIE based bismuth sulfide nanotheranostics for fluorescence imaging and photothermal therapy. Colloids and Surfaces B: Biointerfaces2017; 160(1): 297-304.
  31. Duanping Sun, Zuanguang Chen, Minhao Wu*, Yuanqing Zhang*. Nanomaterial-based Microfluidic Chips for the Capture and Detection of Circulating Tumor Cells. Nanotheranostics2017; 1(4):389-402. doi:10.7150/ntno.21268. 
  32. Duanping Sun, Jing Lu, Xiangyan Wang, Yuanqing Zhang*, Zuanguang Chen*. Voltammetric aptamer based detection of HepG2 tumor cells by using an indium tin oxide electrode array and multifunctional nanoprobes. Microchimica Acta 2017; 84(9): 3487–3496.
  33. Ying Zhu, Jichao Zhang, Aiguo Li, Yuanqing Zhang*, Chunhai Fan*. Synchrotron-based X-ray microscopy for sub-100nm resolution cell imaging. Current Opinion in Chemical Biology. 2017; 15, 11-16.
  34. Weiwei Qin, Guan Huang, Zuanguang Chen*, Yuanqing Zhang*. Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy. Frontiers in Pharmacology. 2017; 18, 1-8.

2016年之前

  1. Yuanqing Zhang, Minhao Wu, Xin Han, Ping Wang, Lidong Qin*. High‐Throughput, Label-Free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity. Angewandte Chemie International Edition 2015; 127，10838-10842.
  2. Yuanqing Zhang, Ledu Zhou, Lidong Qin*. Utilizing a High-Throughput Microfluidic Platform to Study Hypoxia-Driven Mesenchymal-Mode Cell Migration. Integrative Biology 2015； 7，672-680.
  3. Yuanqing Zhang, Ledu Zhou, Lidong Qin*. High-Throughput 3D Cell Invasion Chip Enables Accurate Cancer Metastatic Assays. Journal of the American Chemical Society 2014; 136， 15257-15262.
  4. Yuanqing Zhang, Weijia Zhang, Lidong Qin*. Mesenchymal-Mode Migration Assay and Antimetastatic Drug Screening with High-Throughput Microfluidic Channel Networks. Angewandte Chemie International Edition 2014; 53，2344-2348.
  5. Yuanqing Zhang, Xiaoping Xu, Lu Wang, Jun Lin, Ying Zhu, Zhi Guo, Yanhong Sun*, Hua Wang, Yun Zhao, Renzhong Tai, Xiaohan Yu, Chunhai Fan, Qing Huang*. Dendrimer-folate-copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging. Chemical Communications 2013; 49，10388-10390.
  6. Yuanqing Zhang, Yanhong Sun, XiaopingXu, Xuezhu Zhang, Hua Zhu, Liliang Huang, Yujin Qi, Yu-Mei Shen*. Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates. Journal of Medicinal Chemistry. 2010; 53, 3262-72.

其他

本課題組常年歡迎特聘研究員系列、博士後、研究助理和研究生等優秀科研人員加入。