馮 敏

馮敏

教授

研究領域：核酸、多肽和蛋白藥物傳遞系統理論與新制劑的研究

辦公電話： 020-39943037（o）

聯系郵箱： fengmin@mail.sysu.edu.cn

聯系方式

辦公電話：020-39943073（o）

電子郵箱：fengmin@mail.sysu.edu.cn

辦公地址：廣州市城外環東路132号太阳集团1088vip 510006

簡介

馮敏，藥劑學教授，博士生導師。廣東省高等學校“千百十工程”省級培養對象。廣東省藥學會制藥工程專業委員會副主任委員，廣東省藥學會藥劑專業委員會委員，廣東省科技項目評審專家庫成員。1997年畢業于中國藥科大學獲學士學位，2001年畢業于中山大學獲博士學位。2002-2010年期間先後在新加坡南洋理工大學和美國普渡大學太阳集团1088vip進行博士後和訪問學者研究。2004年任職于太阳集团1088vip，長期從事藥物新劑型與新技術研究，特别是智能藥物傳遞系統理論與新制劑的研究。近年來主持國家自然科學基金、科技部國家高新技術研究發展計劃（863計劃）和廣東省自然科學基金重點項目等10餘項，在ACS Nano、Advanced Science、Journal of Controlled Release、Biomaterials、Molecular Pharmaceutics等雜志上發表高水平研究論文60餘篇。

研究方向

核酸、多肽和蛋白藥物傳遞系統理論與新制劑的研究

教學情況

本科生課程：藥劑學、物理化學、藥用高分子與新型給藥系統、藥物制劑設計與實例

研究生課程：藥用高分子材料、藥劑學進展

科研項目

  1. 國家自然科學基金：谷氨酰胺驅動大分子藥物自傳遞系統觸發溶酶體途徑的級聯反應式抗非小細胞肺癌的作用與機制研究，主持，起止時間：2019.01-2022.12。
  2. 廣州市科技計劃：治療晚期黑色素瘤5-氨基酮戊酸光動力增效制劑的研究，主持，起止時間：2019.01-2021.12。
  3. 廣東省自然科學基金重點項目：基于pHLIP納米載體靶向遞送siRNA重塑腫瘤微環境的機制研究，主持，起止時間：2016.01-2019.12。
  4. 國家自然科學基金：基于腫瘤微環境調控的功能轉換型雜化多肽聚電解質刷載MDR1 siRNA逆轉結腸癌多藥耐藥性的遞送機制研究，主持，起止時間：2014.01-2017.12。
  5. 國家高技術研究發展技術（863計劃）：藥食同源生物資源活性成分高效利用制劑關鍵技術研究，主持，起止時間：2014.01-2016.12。
  6. 高校基本業務費重大項目培育和新興、交叉學科項目：靶向腫瘤轉移微環境聚氨基酸電解質刷載TGF-β siRNA抗結腸癌肝轉移及其遞送機制研究，主持，起止時間：2016.01-2018.12。
  7. 國家自然科學基金：嵌合載體納米粒基因傳遞系統的構建及在基因搭橋中的作用，主持，起止時間：2007.01-2009.12。
  8. 廣東省自然科學基金：聚酰胺-胺納米粒介導MDR1siRNA逆轉結腸癌多藥耐藥性研究，主持人，起止時間：2012.10-2014.10。
  9. 高校基本業務費青年教師重點培育項目：多功能聚谷氨酰胺聚電解質刷遞送siRNA雙靶标逆轉結腸癌多藥耐藥性的研究，主持，起止時間：2013.08-2015.08。
  10. 高校基本業務費青年教師培育項目：維生素B12納米粒口服遞送胰島素及其機制的研究，主持，起止時間：2010.01-2012.12。
  11. 廣東省自然科學基金：靶向肺腺癌TK基因轉移納米粒吸入劑的研究，主持人，起止時間：2007.01-2008.12。

論著專利

  1. Guo L, Zhagn Y, Yang Z, Peng H, Wei R, Wang C*, Feng M*. Tunneling nanotubular expressways for ultrafastand accurate M1 macrophage delivery of anticancer drugs to metastatic ovarian carcinoma. ACS Nano. 2019, 26;13: 1078 - 1096
  2. Li Z, Wang C*, Deng H, Sun R, Huang H, Feng M*. Robust photodynamic therapy using 5-ALA incorporated nanocomplexes cures metastatic melanoma through priming of CD4+CD8+ double positive T cells. Adv Sci, 2019, 6:1802057 
  3. Wang C*, Wu J, Wang Z, Yang Z, Li Z, Deng H, Li L, Peng X, Feng M*. Glutamine addiction activates polyglutamine-based nanocarriers delivering therapeutic siRNAs to orthotopic lung tumor mediated by glutamine transporter SLC1A5. Biomaterials. 2018, 183: 77 - 92. 
  4. Wu J, Li Z, Yang Z, Guo L, Zhang Y, Deng H, Wang C*, Feng M*. A glutamine-rich carrier efficiently delivers anti-CD47 siRNA driven by a "glutamine trap" to inhibit lung cancer cell growth. Mol Pharm. 2018, 15: 3032 – 3045
  5. Zhang X, Wang C, Wu J, Liu Y, Yang Z, Zhang Y, Sui X, Li M, Feng M*. An acid-seeking carrier-free drug achieves high antitumor activity via a “solution-particle” transition. J Control Release. 2017, 262: 305 - 316
  6. Zou HJ, Wang ZJ, Feng M*. Nanocarriers with tunable surface properties to unblock bottlenecks in systemic drug and gene delivery. J Control Release. 2015, 214: 121-133
  7. Yin L, Wang Y, Wang C*, Feng M*. Nano-reservoir bioadhesive tablets enhance protein drug permeability across the small intestine. AAPS PharmSciTech. 2017, 18: 2329 – 2335
  8. Wang Z, Zou H, Wang Z, Wu J, Xia Z*，Feng M*. High stable polyglutamiate derivatives/siRNA polyplex efficiently downregulate surviving expression and augment the efficacy of cisplatin. Int J Pharm. 2016, 505: 24-34 
  9. Cao D, Tian S, Yi W, Dai G, Chen J, Feng M*, Pan S*. Nanocomplexes from RGD-modified generatiuon 1.0 polyamidoamine based copolymer sued for intravascular gene release to prevent restenosis. Nanomedicine (Lond). 2016, 11: 359 – 375 
  10. Tian SQ, Cao D, Zou HJ, Bai F, Wang ZJ, Pan S*, Feng M*. Endothelial cell-targeted pVEGF165 polyplex plays a pivotal role in inhibiting intimal thickening after vascular injury. Int J Nanomedicine. 2015, 10: 5751–5768 
  11. Huang H, Cao D, Qin L, Tian S, Liang Y, Pan S*, Feng M*. Dilution-stable PAMAMG1-grafted polyrotaxane supermolecules deliver gene into cells through a caveolae-dependent pathway. Mol. Pharm. 2014, 11: 2323–2333
  12. Feng M, Ibrahim BM, Wilson EW, Doh KO, Bergman BK, Park C, Yeo Y*. Stabilization of a hyaluronate-associated gene delivery system using calcium ions. Biomater Sci. 2014, 2, 936–942
  13. Zhao Y, Qin Y, Liang Y, Zou H, Peng X, Huang H, Lu M, Feng M*. Salt-induced stability and serum-resistance of polyglutamate polyelectrolyte brushes/nuclear factor-κB p65 siRNA polyplex enhance the apoptosis and efficacy of doxorubicin. Biomacromolecules. 2013, 14 (6): 1777–1786
  14. Wen Y, Guo Z, Du Z, Fang R, Wu H, Zeng X, Wang C, Feng M*, Pan S*. Serum tolerance and endosomal escape capacity of histidine-modified pDNA-loaded complexes based on polyamidoamine dendrimer derivatives. Biomaterials. 2012, 33(32):8111-8121
  15. Wang C, Luo X, Zhao Y, Han L, Zeng X, Feng M*, Pan S, Peng H*, Wu C. Influence of the polyanion on the physico-chemical properties and biological activities of polyanion/DNA /polycation ternary polyplexes. Acta Biomater. 2012, 8(8): 3014-3026
  16. Xu M, Zhao Y, Feng M*. Polyaspartamide derivative nanoparticles with tunable surface charge achieve highly efficient cellular uptake and low cytotoxicity. Langmuir. 2012, 28(31): 11310-11318
  17. Deng J, Wen Y, Wang C, Pan S, Gu H, Zeng X, Feng M*, Wu C. Efficient intracellular gene delivery using the formulation c omposed of poly (L-glutamic acid) grafted polyethylenimine and histone. Pharm Res. 2011, 28(4): 812-826
  18. Shen Y, Peng H, Pan SR, Feng M*, Deng J, Wen YT, Luo X, Wu C. Interaction of DNA/nuclear protein/polycation and the terplexes for gene delivery. Nanotechnology. 2010, 21(4): 045102
  19. Pan S*, Cao D, Huang H, Yi W, Qin L, Feng M*. A serum-resistant low-generation polyamidoamine with PEI 423 outer layer for gene delivery vector. Macromol Biosci. 2013,13(4): 422-36
  20. Han L, Zhao Y, Yin L, Li R, Liang Y, Huang H, Pan S, Wu C, Feng M*. Insulin-loaded pH-sensitive hyaluronic acid nanoparticles enhance transcellular delivery. AAPS PharmSciTech. 2012, 13(3): 836-845
  21. Zeng X, Pan S*, Li J, Wang C, Wen Y, Wu H, Wang C, Wu C, Feng M*. A novel dendrimer based on poly (L-glutamic acid) derivatives as an efficient and biocompatible gene delivery vector. Nanotechnology. 2011, 22(37): 375102
  22. Pan S*, Wang C, Zeng X, Wen Y, Wu H, Feng M*. Short multi-armed polylysine-graft-polyamidoamine copolymer as efficient gene vectors. Int J Pharm. 2011, 420(2): 206-215
  23. Wang C, Feng M*, Deng J, Zhao Y, Zeng X, Han L, Pan S, Wu C. Poly (α-glutamic acid) combined with polycation as serum-resistant carriers for gene delivery. Int J Pharm. 2010, 398(1-2): 237-245
  24. Shen Y, Peng H, Deng J, Wen YT, Luo X, Pan SR, Wu CB, Feng M*. High mobility group box 1 protein enhances polyethylenimine mediated gene delivery in vitro. Int. J Pharm. 2009, 375(1-2): 140-147
  25. Shen Y, Deng J, Luo X, Zeng X, Feng M*, Pan S. Synthesis and characterization of sterically stabilized polyelectrolyte using isophorone diisocyanate as the coupling reagent. J Biomat Sci. Polym Ed. 2009, 20(9): 1217-1233
  26. 韓麗娜,尹麗芳,趙月芳,梁揚,黃歡, 馮敏*. 胰島素／維生素B12-透明質酸納米粒的制備及口服給藥體内外性質的評價. 中山大學學報(醫學科學版). 2012, 33(5): 597-602
  27. 沈媛, 彭輝, 馮敏*, 鄧晶晶, 溫玉婷, 曾昕, 羅昕. 構建HMGB1 /PEI非病毒載體介導高效基因傳遞的研究.中山大學學報(自然科學版). 2009, 48(5): 91-96
  28. Luo X, Feng M, Pan S*, Wen Y, Zhang W, Wu C. Charge shielding effects on gene delivery of polyethylenimine/DNA complexes: PEGylation and phospholipid coating. J Mater Sci Mater Med. 2012, 23(7): 1685-1695
  29. Li J*, Yang G, Feng M, Liang H, Zhang J, Huang D, Deng S, Shen Y. LDL coating pVEGF/polyethylenimine complex enhances vascular endothelial growth factor expression. Biotech Bioproc Eng. 2012, 17(6):1182-1189
  30. Pan S, Cao D, Yi W, Huang H, Feng M. A biodegradable and serum-resistant gene delivery carrier composed of polyamidoamine-poly N, N-di-(2-aminoethyl) aminoethyl glutamine copolymer. Colloids Surf B Biointerfaces. 2012, 104C: 294-302
  31. Tan Y, Yang Z, Pan X, Chen M, Feng M, Wang L, Liu H, Shan Z, Wu C*. Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process. Int J Pharm. 2012, 427(2): 385-392
  32. Tan Y, Yang Z, Peng X, Xin F, Xu Y, Feng M, Zhao C, Hu H, Wu C*. A novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants. Int J Pharm. 2011, 413(1-2): 167-173
  33. Luo X, Pan S*, Feng M, Wen Y, Zhang W. Stability of poly(ethylene glycol)-graft -polyethylenimine copolymer/DNA complexes: influences of PEG molecular weight and PEGylation degree. J Mater Sci: Mater Med. 2010, 21(2): 597–607
  34. Guosen H, Feng M, Luo X, Venkatraman S*. Design, synthesis and in vitro evaluation of a novel "stealth" polymeric gene vector. Int J Pharm. 2008, 350(1-2): 344–350
  35. Wen Y, Pan S*, Luo X, Zhang X, Zhang W, Feng M. A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector. Bioconjug Chem. 2009, 20(2): 322-332
  36. Zhang X, Pan SR, Hu HM, Wu GF, Feng M, Zhang W, Luo X. Poly(ethylene glycol)-block –poly ethylenimine copolymers as carriers for gene delivery: Effects of PEG molecular weight and PEGylation degree. J Biomed Mater Res A. 2008, 84(3): 795-804.
  37. Feng M and Li P. Amine-Containing Core-Shell Nanoparticles as Potential Drug Carriers for Intracellular Delivery. J Biomed Mater Res Part A. 2007, 80(1): 184-93
  38. Siu YS, Feng M, Peng X.  Efficient gene delivery using a novel core-shell nanoparticle and HMGB1 system. FASEB J. 2006, 20 (4): A526-A526.
  39. Feng M, Lee D and Li P. Intracellular uptake and release of poly (ethyleneimine) –co- poly (methyl methacrylate) nanoparticle/pDNA complexes for gene delivery. Int J Pharm. 2006, 311(1-2): 209-214.
  40. Pan J, Venkatraman SS, Feng M. Micelle-like nanoparticles of star-branched PEO–PLA copolymers as chemotherapeutic carrier.  J Control Release. 2005, 111(1): 511-524
  41. 31.Venkatraman SS, Pan J, Feng M. Micelle-like nanoparticles of PLA–PEG–PLA triblock copolymer as chemotherapeutic carrier. Int J Pharm. 2005, 298(1): 219-232
  42. 32.Zhu JM, Tang A, Feng M, et al. Amphiphilic Core-Shell Nanoparticles with Poly(ethylenimine) Shells as Potential Gene Delivery Carriers. Bioconjugate Chem.  2005, 16(1): 139-146