簡單介紹

鄒滔滔，博士，中山大學教授、博士生導師，國家優秀青年基金獲得者，廣東省“珠江人才計劃”青年拔尖人才，中山大學“百人計劃”中青年傑出人才。本科畢業于武漢大學化學學院（導師：楊楚羅教授），博士畢業于香港大學化學系（導師：支志明院士），并在Scripps研究所（導師：Xiang-Lei Yang教授、Paul Schimmel教授)、香港大學（導師：支志明教授）、華威大學（導師Peter J Sadler教授）從事博士後研究工作，研究方向為藥物化學生物學和生物無機化學，長期緻力于開發含金屬藥物，近期研究方向集中在設計新型抗癌前體藥物和發展具有抗癌免疫活性的小分子藥物等領域，并以通訊作者在Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Coord. Chem. Rev.等期刊發表多篇論文。

ORCID: https://orcid.org/0000-0001-9129-4398

Researcher ID: G-2044-2018 

 

招生招聘信息

  1. 課題組長期招聘具有化學生物學、藥物化學、生物無機背景，對抗癌藥物感興趣的博士後和專職科研人員，提供優厚待遇。
  2. 歡迎報考本課題組2025級碩士研究生（學碩、專碩均可）。
  3. 歡迎對藥物化學生物學感興趣的本科生到實驗室交流學習。

 

所獲榮譽

  • 2021年  國家自然科學基金“優秀青年科學基金”
  • 2020年  AsBIC Graeme Hanson Early Career Award (亞洲生物無機化學學會青年科學家獎)
  • 2019年 “珠江人才計劃”引進青年拔尖人才
  • 2019年  深圳市自然科學一等獎（排名第五）
  • 2016年  CAS/SciFinder Future Leaders
  • 2015年  Reaxys PhD Prize (Finalist)
  • 2015年  Springer Theses Prize
  • 2015年  Li Ka Shing Prize
  • 2014年  Hong Kong Young Scientist Award（winner） 

 

代表性論文

  • 獨立工作

  1. Xie, Z.†; Cao, B.†; Zhao,†; Liu, M.†; Lao, Y.; Luo, H.; Zhong, Z.; Xiong, X.; Wei, W.*; Zou, T.* Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes. J. Am. Chem. Soc. 2024, https://doi.org/10.1021/jacs.4c00408

  2. Liu, M.; Luo, Y.; Yan, J.; Xiong, X.; Xing, X.*; Kim, J. S.*; Zou, T.* Photoactivation of Boronic Acid Prodrugs via a Phenyl Radical Mechanism: Iridium(III) Anticancer Complex as an Example. J. Am. Chem. Soc. 2023, 145, 10082-10091.

  3. Jiang, J.†; Xiong, X.†; Zou, T.* Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications. Acc. Chem. Res. 2023, 56, 1043-1056.

  4. Luo, Y.; Cao, B.; Zhong, M.; Liu, M.; Xiong, X.; Zou, T.*, Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for Robust Cancer Therapy. Angew. Chem. Int. Ed. 2022, 61 e202212689.

  5. Xiong, X.†; Huang, K.-B.†; Wang, Y.†; Cao, B.; Luo, Y.; Chen, H.; Yang, Y.; Long, Y.; Liu, M.; Chan, A. S. C.; Liang, H.*; Zou, T.*, Target Profiling of an Iridium(III)-based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP. J. Am. Chem. Soc. 2022, 144, 10407-10416..

  6. Jiang, J.†; Cao, B.†; Chen, Y.†; Luo, H.; Xue, J.; Xiong, X.; Zou, T.*, Alkylgold(III) Complexes Undergo Unprecedented Photo-Induced β-Hydride Elimination and Reduction for Targeted Cancer Therapy. Angew. Chem. Int. Ed. 2022, 61, e202201103.
  7. Xiong, X.; Liu, L.-Y.; Mao, Z.-W.*; Zou, T.* Approaches towards understanding the mechanism-of-action of metallodrugs. Coord. Chem. Rev. 2022, 453, 214311.
  8. Long, Y.†; Cao, B.†; Xiong, X.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems. Angew. Chem. Int. Ed. 2021, 60, 4133-4141. (Hot Paper)
  9. Luo, H.; Cao, B.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, Cyclometalated Gold(III)-Hydride Complexes Exhibit Visible Light-Induced Thiol Reactivity and Act as Potent Photo-Activated Anti-Cancer Agents. Angew. Chem. Int. Ed. 2020, 59, 11046-11052. (Hot Paper, highlighted as inside back cover)
  • 博士和博士後期間工作
  1. Zou, T.;† Lok, C.-N.,† Wan, P.-K., Zhang, Z.-F., Fung, S.-K., Che, C.-M.* Anticancer Metal N-Heterocyclic carbene complexes of gold, platinum and palladium, Curr. Opin. Chem. Biol., 2018, 43, 30-36.
  2. Fung, S. K.;† Zou, T.;† Cao, B.; Lee, P.-Y.; Fung, Y. M. E.; Hu, D.; Lok, C.-N.; Che, C.-M.*, Cyclometallated Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands Engage Multiple Anti-Cancer Molecular Targets, Angew. Chem. Int. Ed. 2017, 56, 3892-3896. (Very Important Paper).
  3. Fung, S. K.;† Zou, T.;† Cao, B.; Chen, T.; To, W.-P.; Yang, C.; Lok, C.-N.; Che, C.-M.*, Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA, Nat. Commun. 2016, 7, 10655.
  4. Zou, T.; Lum, C. T.; Lok, C.-N.; Zhang, J.-J.; Che, C.-M.*, Chemical biology of anticancer gold(III) and gold(I) complexes. Chem. Soc. Rev. 2015, 44, 8786-8801 (Outside Front Cover).
  5. Tsai, J. L.-L.;† Zou, T.;† Liu, J.; Chen, T.; Chan, A. O.-Y.; Yang, C.; Lok, C.-N.; Che, C.-M.*, Luminescent platinum(ii) complexes with self-assembly and anti-cancer properties: hydrogel, pH dependent emission color and sustained-release properties under physiological conditions. Chem. Sci. 2015, 6, 3823-3830.
  6. Zou, T.; Lum, C. T.; Lok, C.-N.; To, W.-P.; Low, K.-H.; Che, C.-M.*, A Binuclear Gold(I) Complex with Mixed Bridging Diphosphine and Bis(N-Heterocyclic Carbene) Ligands Shows Favorable Thiol Reactivity and Inhibits Tumor Growth and Angiogenesis In Vivo. Angew. Chem. Int. Ed. 2014, 53, 5810-5814.
  7. Zou, T.;† Liu, J.;† Lum, C. T.; Ma, C.; Chan, R. C.-T.; Lok, C.-N.; Kwok, W.-M.; Che, C.-M.*, Luminescent Cyclometalated Platinum(II) Complex Forms Emissive Intercalating Adducts with Double Stranded DNA and RNA: Differential Emissions and Anticancer Activities. Angew. Chem. Int. Ed. 2014, 53, 10119-10123.
  8. Lok, C.-N.;† Zou, T.;† Zhang, J.-J.; Lin, I. W.-S.; Che, C.-M.*, Controlled-Release Systems for Metal-Based Nanomedicine: Encapsulated/Self-Assembled Nanoparticles of Anticancer Gold(III)/Platinum(II) Complexes and Antimicrobial Silver Nanoparticles. Adv. Mater. 2014, 26, 5550-5557.
  9. Zou, T.; Lum, C. T.; Chui, S. S.-Y.; Che, C.-M.*, Gold(III) Complexes Containing N-Heterocyclic Carbene Ligands: Thiol “Switch-on” Fluorescent Probes and Anti-Cancer Agents. Angew. Chem. Int. Ed. 2013, 52, 2930-2933 (Very Important Paper)

    († equal contribution, * Corresponding author)

 

書籍（章節）

  1. Zou, T., Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents; Springer Theses, Springer, 2016, ISBN 978-981-10-0657-9.
  2. Zou, T., Hung, F.-F., Yang, C., Che, C.-M.* Strongly Phosphorescent Transition-Metal Complexes with N-Heterocyclic Carbene Ligands as Cellular Probes. In: Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents Vol. 165 (Ed.: Lo, K. K.-W.). Springer Berlin Heidelberg, 2015, pp. 181-203.

 

專利

  1.  鄒滔滔，羅和江，陳新滋，一種光響應的環金屬金(III)氫化物及其制備方法和應用。中國發明專利申請，專利号201911367140.1.
  2. Chi Ming Che, Taotao Zou, Novel gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and applications in cancer treatment and thiol detection. PCT Int. Appl. US 14/078,742, US8828984 B2 (granted), EP2920186A1, EP2920186A4, US20140142080, WO2014075394A1.
  3.  Chi Ming Che, Taotao Zou, A method of using binuclear gold(I) compounds for cancer treatment. PCT Int. Appl. US 14/070,096, US9238659 B2 (granted), CN105452258A, EP2920187A1, EP2920187A4, US20140142065, WO2014075574A1.
  4. Chi Ming Che, Sin Ki Fung, Taotao Zou, A method of using d8 square planar metal complexes to target mismatched DNA. PCT Int. Appl. US 2016-0369354-A1 .