個人簡介

       

        蔣先興(Xianxing Jiang)，男，博士，教授，博士生導師。教育部“長江學者獎勵計劃”特聘教授、中組部“海外高層次引進人才”項目入選者、“廣東特支計劃”百千萬工程青年拔尖人才、中山大學“逸仙學者傑出學者”、廣東省“珠江人才計劃”引進創新團隊第一核心成員。

        已申請國内國際（PCT）發明專利54項，授權28項，其中，美國、歐盟、澳大利亞、日本等授權13項。作為第一發明人，已成功實現多項科研成果轉化應用于1.1類創新藥物研發進入臨床。另有多項研究成果在臨床前研究階段。迄今為止，已在 Chem. Rev.、Nat. Commun.、J. Am. Chem. Soc.、Adv. Sci.、Angew. Chem. Int. Ed.、Acta Pharm Sin B.、J. Med. Chem.等國際知名刊物發表論文 80 餘篇，共被他引 4000 餘次; 2 篇論文入選 Web of Science ESI 高被引論文。

         作為負責人，承擔國家自然科學基金重大研究計劃培育項目、國家自然科學基金面上項目等多項科研基金。

 

研究方向

       

          藥物化學，化學生物學，抗體、多肽藥物設計發現及研究。

 

教育及工作經曆

 

  • 2000年09月 – 2005年07月    蘭州大學，獲學士學位
  • 2005年09月 – 2008年06月    蘭州大學，獲生物化學與分子生物學專業碩士學位，導師：王銳院士
  • 2009年09月 – 2011年12月    蘭州大學，功能有機分子國家重點實驗室，獲有機化學專業博士學位，導師：王銳院士
  • 2012年08月 – 2014年09月    在美國斯克利普斯研究所 (The Scripps Research Institute) 從事博士後研究，師從抗體生物                                                      化學和有機催化領域先驅 Carlos F. Barbas III 教授
  • 2014年09月 – 至今                太阳集团1088vip，教授，博士生導師

 

招聘及招生信息 

 

         本課題組和所在研究團隊長期招聘具有藥學、化學、生物學或相近專業背景，對蛋白修飾、抗體和生物大分子藥物感興趣的特聘副研究員、博士後和研究助理。

         本課題組目前有2025年的博士和碩士名額若幹，歡迎有志于藥物和化學生物學研究的考生報考。

 

代表性論文

  1. Zihan Shi#, Xianyan Liu#, Shuohan Wu#, Nazi Song, Qinglin Tang, Haonan Li, Suijia Luo, Albert S. C. Chan, Xiaoqing Cai*, Han Liu*, Xianxing Jiang*. Discovery of Novel Peptide Antagonists Targeting GPR55 for Liver Inflammation and Fibrosis. Journal of Medicinal Chemistry, 2024,67(14):12085-12098.

  2. Yixiang Wang#, Fanghan Xue#, Wei Cheng#, Qian Zhao, Nazi Song, Zihan Shi, Han Liu, Yu Li, Qinglin Tang, Qi Liu, Yiqing Wang*, Fangfang Zhang*, Xianxing Jiang*. Design and Synthesis of Novel Ultralong-Acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment. Journal of Medicinal Chemistry, 2024,67(8):6624-6637.

  3. Qian Zhao#, Jiale Dong#,Han Liu#, Hui Chen, Huan Yu, Shuyin Ye, Shuangjin Yu, Yu Li, Longhui Qiu, Nazi Song, Hongjiao Xu, Qi Liu, Zhiteng Luo, Yuyi Li, Rui Wang*, Guodong Chen*, Xianxing Jiang*. Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis. Acta Pharmaceutica Sinica B., 2024,14(3):1283-1301.

  4. Xiaocui Feng#, Jianfeng Zhang#, Runling Yang, Hong Lei, Wanru Chen, Jingya Bai, Kai Feng, Feiyun Gao, Wenle Yang, Xianxing Jiang*, Bangzhi Zhang*. The novel peptide PEP-Z-2 potentially treats renal fibrosis in vivo and in vitro by regulating TGF-beta/Smad/AKT/MAPK signaling. European journal of pharmacology , 2024,982(5):176942.

  5. Jiale Dong#, Jing Xiao#, Jianyi Li#, Huan Yu, Qian Zhao, Qinglin Tang, Hui Chen, Han Liu, Kejue Wu,Jinping Lei, Rui Wang, Xianxing Jiang*. Discovery and Design of Novel Cyclic Peptides as Specific Inhibitors Targeting CCN2 and Disrupting CCN2/EGFR Interaction for Kidney Fibrosis Treatment. Journal of Medicinal Chemistry, 2023,66(12):8251-8266.

  6. Nazi Song#, Haonan Li#,Qinglin Tang#, Suijia Luo, Zihan Shi, Qian Zhao, Runkai Li, Yili Chen*, Xiaoqing Cai*, Xianxing Jiang*. Design and Discovery of Novel Cyclic Peptides as EDPs-EBP Interaction Inhibitors for the Treatment of Liver Fibrosis. Journal of Medicinal Chemistry,2023,66(7):4689-4702
  7. Nazi Song#, Hongjiao Xu#, Shuohan Wu#, Suijia Luo, Jingyao Xu, Qian Zhao, Rui Wang, Xianxing Jiang*. Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of EDPs–EBP interaction recover NAFLD through enhancing mitochondrial function in mice. Acta Pharmaceutica Sinica B.,2023,13(2):542-558
  8. Yuji Qin#, Liang Qi#, Xiang Zhen, Xueqing Wang, Hongli Chai, Xingyu Ma, Xianxing Jiang*, Xiaoqing Cai*,Weiwei Zhu*. Different Performances of BF3, BCl3, and BBr3 in Hypervalent Iodine-Catalyzed Halogenations. The Journal of Organic Chemistry, 2023,88(7): 4359-4371.
  9. Jinfeng Yu#, Haonan Li#, Tong Fang#, Chengyu Yun, Xue Liu, Jingyao Xu, Xianxing Jiang*, Xiaoqing Cai*. Harnessing the Lysosomal Sorting Signals of the CationIndependent Mannose-6-Phosphate Receptor for TargetedDegradation of Membrane Proteins. Journal of The American Chemical Society, 2023,145(34):19107-19119.

  10. Bao Cheng#, Zhengjun Cai#, Ziqing Luo#, Siting Luo, Zhiteng Luo, Yanfang Cheng, Ying Yu, Junsong Guo, Yingchen Ju, Qiong Gu, Jun Xu, Xianxing Jiang*, Geng Li*, Huihao Zhou*. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. Journal of Medicinal Chemistry, 2022,65(23):15840-15855.
  11. Xueqing Wang#, Xuerong Chen, Liang Qi, Xingyu Ma, Yifeng Zhou*, Xianxing Jiang*, Weiwei Zhu*. Halogenation of Unsaturated Amides: Synthesis of Halogenated (Spiro)Oxazolines. ChemistrySelect, 2022,7(42):e202203419(1-6).

  12. Nazi Song#, Hongjiao Xu#, Jiahua Liu#, Qian Zhao#, Hui Chen, Zhibin Yan, Runling Yang, Zhiteng Luo, Qi Liu, Jianmei Ouyang, Shuohan Wu, Suijia Luo, Shuyin Ye, Runfeng Lin, Xi Sun, Junqiu Xie, Tian Lan, Zhongdao Wu*, Rui Wang*,  Xianxing Jiang*. Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis. Acta Pharmaceutica Sinica B.,  2022,12(5): 2443-2461.

  13. Xiaoyun Zhao#, Bai Li#, Jingyao Xu, Qinglin Tang, Zhengjun Cai, Xianxing Jiang*. Visible-Light-Driven Redox Neutral Direct C-H Amination of Glycine Derivatives and Peptides with N-Acyloxyphthalimides. Chemistry-a European Journal, 2021,27(49):12540-12544.

  14. Weiwei Zhu#, Xiang Zhen, Jingyuan Wu, Yaping Cheng, Junkai An, Xingyu Ma, Jikun Liu, Yuji Qin, Hao Zhu, Jijun Xue, Xianxing Jiang*. Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagen. Nature communications, 2021,12(1):3957(1-8).

  15. Yu Wang#, Donglan Liu, Huihuang Lin, Dingbin Chen, Jing Sun, Yusang Xie, Xinjie Wang, Peixiang Ma, Yan Nie, Hone Mei, Baihui Zhao, Xingxu Huang, Ge Jiang, Xianxing Jiang*, Jieming Qu*, Jincun Zhao*, Jia Liu*. Development of a Broadly Applicable Cas12a-Linked Beam Unlocking Reaction for Sensitive and Specific Detection of Respiratory Pathogens Including SARS-CoV-2. Acs Chemical Biology, 2021,16(3):491-500.

  16. Zhibin Yan#, Dan Wang, Chunmei An, Hongjiao Xu, Qian Zhao, Ying Shi, Nazi Song, Bochuan Deng, Xiaomin Guo, Jing Rao, Lu Cheng, Bangzhi Zhang, Lingyun Mou, Wenle Yang, Xianxing Jiang*, Junqiu Xie*. The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis. Acta Pharmaceutica Sinica B., 2021,11(1):100-111.

  17. Hongjiao Xu#, Qian Zhao#, Nazi Song#, Zhibin Yan, Runfeng Lin, Shuohan Wu, Lili Jiang, Sihua Hong, Junqiu Xie, Huihao Zhou, Rui Wang, Xianxing Jiang*. AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis. Nature communications, 2020,11(1):5807(1-16).  

  18. Qian Zhao#, Guoying Guo#, Weiwei Zhu, Liping Zhu, Yifan Da, Ying Han, Hongjiao Xu, Shuohan Wu, Yaping Cheng, Yani Zhou, Xiaoqing Cai*, Xianxing Jiang*. Suzuki Cross-Coupling Reaction with Genetically Encoded Fluorosulfates for Fluorogenic Protein Labeling. Chemistry-a European Journal, 2020,26(68):15938-15943.

  19. Jiale Xiong#, Xiaoyun Zhao, Xing Feng, Xianxing Jiang*. Decarboxylative Propargylation /Hydroamination/Aromatization Enabled by Copper/Amine Cooperative Catalysis: Construction of Cyclopenta b indole Derivatives. Current Organic Chemistry, 2020,24(12):1384-1395.

  20. Junkai An#, Jikun Liu#, Ying Shi#, Weiwei Zhu, Guoying Guo, Xianxing Jiang*, Jijun Xue*, Hongrui Zhang. Lewis Acid-Mediated Efficient Synthesis of 4H-1,3-benzo-xazines and Their Derivatives 4,5-dihydro-1,3-benzo-xazepines. Current Organic Chemistry, 2020, 24(11):1263-1273.

  21. Weiwei Zhu#, Fuchong Li#, Jikun Liu, Xingyu Ma, Xianxing Jiang*. Nucleophilic construction of sulfate bonds: simplified access to polysulfates and polysulfonates. Reaction Chemistry & Engineering, 2019,4(12):2074-2080.

  22. Hongjiao Xu#, Sihua Hong, Zhibin Yan, Qian Zhao, Ying Shi, Nazi Song, Junqiu Xie*, Xianxing Jiang*. RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress. Life Sciences, 2019,229:200-109.

  23. Bai Li#, Xianhao Zhou#, Pengyu Yang, Liping Zhu, Yuan Zhong, Zhengjun Cai, Biao Jiang, Xiaoqing Cai, Jia Liu*, Xianxing Jiang*. Photoactivatable Fluorogenic Labeling via Turn-On“Click-Like” Nitroso-Diene Bioorthogonal Reaction. Advanced Science, 20 19,6(13):1802039(1-11).

  24. Xiaoyun Zhao#, Jiale Xiong, Junkai An, Jicong Yu, Liping Zhu, Xing Feng, Xianxing Jiang*. Diastereodivergent construction of bispiro[oxindole-bi-pyrrolidine]s with four consecutive stereocenters via asymmetric [3+2] cycloaddition of 2,3-dioxopyrrolidines using identical catalysts, Organic Chemistry Frontiers. 2019,6(12):1989-1995.

  25. Liping Zhu#, Jiale Xiong, Junkai An, Nannan Chen, Jijun Xue*, Xianxing Jiang*. Highly efficient regio-selective ring-opening nucleophilic fluorination of aziridines and azetidines: access to beta- or gamma-fluorinated amino acid derivatives, Organic＆Biomolecular Chemistry, 2019,17(15):3797-3804.

  26. Pei Tong#, Ying Li*, Yuan Zhang*, Xianxing Jiang*. Triphenylphosphine-Catalyzed Diastereoselective Addition of Oxazolones to Isatin-Derived Ketimines: Construction of Vicinal N-Substituted Quaternary Stereocenters. Asian Journal of Organic Chemistry, 2019,8(4):492-495.

  27. Hongjiao Xu#，Lu Gan#, Ying Han, Yifan Da, Jiale Xiong, Sihua Hong, Qian Zhao, Nazi Song, Xiaoqing Cai*, Xianxing Jiang*. Site-specific labeling of an anti-MUC1 antibody: probing the effects of conjugation and linker chemistry on the internalization proces. RSC Advances, 2019,9(4):1909-1917.

  28. Qian Zhao#, Hongjiao Xu#, Sihua Hong#, Nazi Song, Junqiu Xie, Zhibin Yan, Rui Wang, Pengyu Yang*, Xianxing Jiang*. Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice.  Molecular Pharmaceutics, 2019,16(1):371-381.

  29. Chujun Zhou#, Hui Gao#, Shiliang Huang, Shangshi Zhang, Jiaqiang Wu, Bai li, Xianxing Jiang*, Honggen Wang*. Synthesis of Benzofused N-Heterocycles via Rh(Ⅲ)-Catalyzed Direct  Benzannulation with 1,3-Dienes. ACS Catalysis, 2019,9(1):556-564.

  30. Yanfang Wang#, Liping Zhu#, Mengran Wang, Jiale Xiong, Nannan Chen, Xing Feng, Zhaoqing Xu*, Xianxing Jiang*. Catalytic Asymmetric [4+3] Annulation of C,N-Cyclic Azomethine Imines with Copper Allenylidenes. Organic Letters, 2018,20(20):6506-6510.

  31. Junqiu Xie#, Yao Li, Jing Li, Zhibin Yan, Dan Wang, Xiaomin Guo, Jianfeng Zhang, Bangzhi Zhang, Lingyun Mou, Wenle Yang, Xianxing Jiang*. Potent effects of amino acid scanned antimicrobial peptide Feleucin-K3 analogs against both multidrug-resistant strains and biofilms of Pseudomonas aeruginosa. Amino Acids, 2018,50(10):1471-1483.

  32. Yuan Zhong#, Xiaoyun Zhao#, Lu Gan, Sihua Hong, Xianxing Jiang*. Phosphine-Catalyzed Enantioselective [4+2] Cycloaddition–Semipinacol-Type-Rearrangement Reaction of Morita–Baylis–Hillman Carbonates. Organic Letters, 2018,20(14):4250-4254.

  33. Jicong Yu#, Lemao Yu#, Xiaoyun Zhao, Lu Gan, Weiwei Zhu, Zechen Wang, Rui Wang, Xianxing Jiang*. Organocatalytic Asymmetric [3+2] Annulation of 1, 4-Dithiane-2,5-diol with Azlactones: Access to Chiral Dihydrothiophen-2(3H)-one Derivatives. Organic Chemistry Frontiers, 2018,5(13):2040-2044.

  34. Nannan Chen#, Liping Zhu#, Lu Gan, Zhenquan Liu, Rui Wang, Xiaoqing Cai*, Xianxing Jiang*. Asymmetric Synthesis of Bispiro [γ-butyrolactone-pyrrolidin-4,4’-pyrazolone] Scaffolds Containing Two Quaternary Spirocenters via an Organocatalytic 1,3-Dipolar Cycloaddition. European Journal of Organic Chemistry, 2018,2018(23):2939-2943.

  35. Zhengjun Cai#, Jianbao Gao, Bai Li, Yuan Zhong, Jijun Xue*, Xianxing Jiang*. The Application of [4+2] Cycloaddition Reaction of Tetrazine with Cyclooctyne in the Construction of Pyridazine Structure with Axial Chirality. Chinese Journal of Organic Chemistry, 2018,38(5):1138-1146.

  36. Lemao Yu#, Yuan Zhong, Jicong Yu, Lu Gan, Zhengjun Cai, Rui Wang, Xianxing Jiang*. Highly diastereoselective oxa-[3+3] cyclization with C,N-cyclic azomethine imines via the copper-catalyzed aerobic oxygenated C[double bond, length as m-dash]C bond of indoles. Chemical Communications, 2018,54(19):2353-2356.

  37. Yuan Zhong#, Sihua Hong#, Zhengjun Cai, Shixiong Ma, Xianxing Jiang*. Direct β-selectivity of α,β-unsaturated γ-butyrolactam for asymmetric conjugate additions in an organocatalytic manner. RSC Advances, 2018,8(51):28874-28878.

  38. Junqiu Xie#, Qian Zhao, Sisi Li, Zhibin Yan, Jing Li, Yao Li, Lingyun Mou, Bangzhi Zhang, Wenle Yang, Xiaokang Miao, Xianxing Jiang*, Rui Wang*. Novel antimicrobial peptide CPF-C1 analogs with superior  stabilities and activities against multidrug-resistant bacteria. Chemical Biology ＆ Drug Design, 2017,90(5):690-702.

  39. Dan Li#, Dongxu Yang#, Linqing Wang, Xihong Liu, Xianxing Jiang*, Rui Wang*. MgII-Catalyzed Desymmetrization Reaction of me so-Aziridines with Hydroxylamines: Synthesis of Novel Chiral 1,2-Diamine Skeletons. Chemistry-a European Journal, 2016,22 (48):17141-17144.

  40. Dan Li#, Yijie Wang#, Linqing Wang, Jie Wang, Pengxin Wang, Kezhou Wang, Li Lin, Dongsheng Liu* ,Xianxing Jiang*, Dongxu Yang*. Simple Magnesium Catalyst Mediated c-butyrolactams in Desymmetrization of Meso-aziridines. Chemical Communications, 2016,52(62):9640-9643.

  41. Linqing Wang#, Dongxu Yang#, Dan Li, Pengxin Wang, Kezhou Wang, Jie Wang,  Xianxing Jiang*, Rui Wang*. MgII-Mediated Catalytic Asymmetric Dearomatization (CADA)Reaction of b-Naphthols  with Dialkyl Acetylenedicarboxylates. Chemistry-a European Journal, 2016,22(25):8483-8487.

  42. Jijun Xue#, Hongrui Zhang, Tian Tian, Keshu Yin, Dongxue Liu, Xianxing Jiang*, Ying Li*, Xiaojie Jin, Xiaojun Yao. Organohalo genite-Catalyzed Spiroketalization: Enantioselective Synthesis of Bisbenzannulated Spiroketal Cores. Advanced Synthesis ＆Catalysis, 2016,358(3):370-374.

  43. Yulong Sun#, Jia Liu#, Xianxing Jiang*, Tao Sun,  Luping Liu,  Xiaoyuan Zhang, Shaoli Ding, Jingyi Li, Yan Zhuang, Yiqing Wang, Rui Wang*. One-Step  Synthesis of Chiral Oxind. Scientific Reports, 2015,5:13699(1-7).

  44. Weidong Kong#, Quanping Guo#, Zhaoqing Xu*, Guoqiang Wang, Xianxing Jiang*, Rui Wang*. Iodine(III)- Mediated Oxy-fluorination of Alkenyl Oximes: An Easy Path to Monofluoromethyl- Substituted Isoxazolines. Organic Letters, 2015,17(15):3686-3689.

  45. Qiao Chen#, Hongmei Yu, Zhaoqing Xu*, Li Lin, Xianxing Jiang*, Rui Wang*. Development and  Application of O- (Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes. Journal of Organic Chemistry, 2015,80(13):6890-6896.

  46. Yuan Zhong#, Shixiong Ma#, Bai Li, Xianxing Jiang*, Rui Wang*. Diastereoselective Synthesis of  Biheterocyclic Tetrahydrothiophene Derivatives via Base-Catalyzed Cascade  Michael-Aldol [3+2] Annulation of 1,4-Dithiane-2,5-diol with Maleimides. Journal of Organic Chemistry, 2015,80(13):6870-6874.
  47. Xianxing Jiang#*, Luping Liu#, Panpan Zhang, Yuan Zhong, Rui Wang*. Catalytic Asymmetric β, γ Activation of α ,β-Unsaturated γ-Butyrolactams: Direct Approach to β,γ- Functionalized Dihy drop yranopyrrolidin-2-ones**.  Angewandte Chemie-International Edition, 2013,52(43):11329-11333.
  48. Xianxing Jiang#, Bin Tan, Carlos F. Barbas III*. Core-Structure-Motivated Design of  Iminium Enolate Organocascade Reactions: Enantioselective Syntheses of 5,6-Dihydroindolizines. Angewandte Chemie-International Edition,  2013,52(35):9261-9265.
  49. Xianxing Jiang#, Rui Wang*. Recent Developments in Catalytic Asymmetric Inverse- Electron Demand Diels−Alder Reaction.  Chemincal Reviews,  2013,113(7):5515-5546.
  50. Xianxing Jiang#, Xiaomei Shi, Shoulei Wang, Tao Sun, Yiming Cao, Rui Wang*. Bifunctional Organocatalytic Strategy for Inverse- Electron-Demand Diels-Alder Reactions:Highly Efficient In Situ Substrate Generation and Activation to Construct Azaspirocyclic Skeletons**.  Angewandte Chemie-International Edition,  2012,51(9):2084-2087.
  51. Yiming Cao#, Xianxing Jiang#, Luping Liu, Fangfang Shen, Futing Zhang, Rui Wang*. Enantioselective Michael/Cyclization Reaction Sequence:ScaffoldInspired Synthesis of Spirooxindoles with Multiple Stereocenters**. Angewandte Chemie-International Edition,  2011,50(39):9124-9127.
  52. Xianxing  Jiang#, Yiming Cao, Yiqing Wang, Luping Liu, Fangfang Shen,  Rui Wang*.  A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a MorePotent Oxindole-Type Phytoalexin Analogue. Journal of the American Chemical Society,  2010,132(43):15328–15333.

 

獲獎情況

 

        2020年第十六屆中國國際多肽學術會議多肽青年論文獎（Young Peptide Scientist Award）

        2017年中國藥學會頒發的中國藥學會—法國施維雅青年藥物化學紀念獎章

        2015年第一屆全國多肽藥物研發及規模化生産前沿技術學術會議“傑出青年獎”

        2014 年教育部自然科學一等獎（排名第二）

        2013 年中國藥學會科學技術一等獎（排名第三）

        2012 年中國藥學會-法國施維雅青年藥物化學獎（2012CPA-Servier Young Investigator Awards in Medicinal Chemistry）

        2010 年中科院院長獎學金

        2010 年國家中科院博士研究生訪問研究獎學金