簡單介紹

王洪根，博士，國家重大人才項目入選者，國家優青，中山大學教授，博導。2013年9月通過“中山大學百人計劃急需人才計劃”進入太阳集团1088vip工作。廣東省高等學校“優秀青年教師培養計劃”、廣東省特支計劃百千萬工程青年拔尖人才和廣東省高等學校“千百十人才培養工程”校級培養對象。現為嶺南有機化學專業委員會委員，廣東省藥學會第十七屆理事會藥物化學專業委員會委員。曾獲Thieme Chemistry Journals Award 2020，中國科學院優秀博士學位論文獎，中國科學院院長獎學金優秀獎，中國科學院優秀畢業生，廣州市科技進步二等獎（團隊），廣東省科技進步三等獎（團隊）。目前主持中山大學“百人計劃”啟動基金，國家自然科學基金面上項目，國家自然科學基金青年科學基金等多個基金項目，并參與國家重大研究計劃一項。主要研究領域為有機合成化學、藥物合成化學、天然産物全合成等。至今在J. Am. Chem. Soc.，Angew. Chem. Int. Ed., Science (perspective), ACS Catal.等雜志發表論文60餘篇，文章累計被引用3000餘次。

ORCID: http://orcid.org/0000-0002-9648-6759

課題組主頁：https://www.x-mol.com/groups/SYSU-Wang_Honggen

 

本課題組長期招聘具藥物化學，有機化學等相關專業背景的特聘研究員、特聘副研究員和博士後。

課題組2024年尚有博士碩士招生名額，歡迎廣大考生報考。

 

研究方向

合成化學，天然産物全合成，藥物化學

教育經曆

2011年9月至2013年8月：博士後，德國明斯特大學，合作導師：Prof. Dr. Frank Glorius；
2006年9月至2011年7月：博士，中國科學院廣州生物醫藥與健康研究院，導師：朱強 研究員，張健存 研究員；
2005年7月至2005年8月：交換生，香港理工大學應用生物及化學科技學系；
2002年9月至2006年7月：理學學士，雙專業：藥學 & 計算機科學，太阳集团1088vip，中山大學計算機科學系。

教學情況

有機化學; 藥物合成策略與實例; 大學化學實驗

論著專利

 

1.      Jiasheng Qian, Zhi-Hao Chen, Yuan Liu, Yin Li, Qingjiang Li, Shi-Liang Huang*, Honggen Wang*, “Synthesis of allenyl-B(MIDA) via hydrazination/fragmentation reaction of B(MIDA)-propargylic alcohol”, Chin. Chem. Lett. 2022, accepted. 

2.      Yang Ling, Ling Yanga, Yuan Liua, Wen-Xin Fana, Dong-Hang Tana, Qingjiang Li, and Honggen Wang*, “Regiocontrolled allylic functionalization of internal alkene via selenium- -acid catalysis guided by boron substitution” Chem. Sci., 2022, https://doi.org/10.1039/D2SC00954D

3.      Xiao-Xuan Su, Yue-Ru Chen, Jia-Qiang Wu, Xiong-Zhi Wu, Kun-Tao Li, Xiao-Na Wang, Jia-Wei Sun, Honggen Wang*, Tian-Miao Ou*, “Design, synthesis, and evaluation of 9-(pyrimidin-2-yl)-9H-carbazole derivatives disrupting mitochondrial homeostasis in human lung adenocarcinoma”, Eur. J. Med. Chem., 2022, 232, 114200

4.      Wen-Xin Lv, Yin Li, Yuan-Hong Cai, Dong-Hang Tan, Zhan Li, Ji-Lin Li, Qingjiang Li and Honggen Wang,* “Hypervalent Iodine-Mediated ß-Difluoroalkylboron Synthesis via An Unusual 1,2-Hydrogen Shift Enabled by Boron Substitution”, Chem. Sci., 2022, 13, 2981–2984;

5.      Dong-Hang Tan, Zhi-Hao Chen, Ling Yang, Chang-Ting Li, Fang-Hai Tu, Qingjiang Li and Honggen Wang,* “A boryl-migratory semipinacol rearrangement”, Sci. China Chem., 2022, 65, 746-752; 

6.      Yimiao He,* Limei Tian, Xuexue Chang, Zeming Qu, Yanmin Huang, Chusheng Huang, Qing Sun,* Honggen Wang,* “Rhodium-catalyzed formal [4+3] annulation reaction of N-methoxybenzamides with gem-difluorocyclopropenes: A combination of experimental and theoretical studies” Chin. Chem. Lett. 2022, https://doi.org/10.1016/j.cclet.2022.01.068;

7.      Yan-Wen Mai, Cheng-Cheng Liang, Jie-Bin Ou, Hua-Ting Xie, Shuo-Bin Chen, Du-Chao Zhou, Pei-Fen Yao, Zhi-Shu Huang, Honggen Wang,* Shi-Liang Huang,* “9-Bromo-2,3-diethylbenzo[de]chromene-7,8-dione (MSN54): A novel non-intercalative topoisomerase II catalytic inhibitor”, Bioorg. Chem., 2021, 114, 105097; 

8.      Chenglong Li, Yangzhen Liao, Xuemei Tan, Xiaozu Liu, Peijun Liu,* Wen-Xin Lv & Honggen Wang* “Hypervalent iodine-mediated gem-difluorination of vinyl halides enabled by exclusive 1,2-halo migration”，Sci. China Chem., 2021, 64, 999–1003；

9.      Yao Liu, Ji-Lin Li, Xu-Ge Liu, Jia-Qiang Wu, Zhi-Shu Huang, Qingjiang Li, Honggen Wang* “Radical Borylative Cyclization of Isocyanoarenes with N-Heterocyclic Carbene Borane: Synthesis of Borylated Aza-arenes” Org. Lett. 2021, 23, 1891–1897.

10.   Ling Yang, Dong-Hang Tan, Wen-Xin Fan, Xu-Ge Liu, Jia-Qiang Wu, Zhi-Shu Huang, Qingjiang Li and Honggen Wang* “Photochemical Radical C-H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of a-Functionalized Alkyl Boronates” Angew. Chem. Int. Ed. 2021, 60，3454-3458.

11.   Yuanhong Cai, Donghang Tan, Qiqi Zhang, Wenxin Lv, Qingjiang Li, Honggen Wang* “Synthesis of Difluoromethylated Benzylborons via Rhodium(I)-Catalyzed Fluorine-Retainable Hydroboration of gem-Difluoroalkenes”, Chinese Chemical Letters, 2021, 32, 417-420.

12.   Zhan Li, Ke-Feng Wang, Xin Zhao, Huihui Ti, Xu-Ge Liu,* Honggen Wang*, “Manganese-Mediated Reductive Functionalization of Activated Aliphatic Acids and Primary Amines”, Nature Communications, 2020, 11: 5036

13.   Yao-Fu Zeng,* Xu-Ge Liu, Dong-Hang Tan, Wen-Xin Fan, Yi-Na Li, Yu Guo and Honggen Wang* “Halohydroxylation of Alkenyl MIDA Boronates: Switchable Stereoselectivity Induced by B(MIDA) Substituent”, Chem. Commun., 2020, 56, 4332 – 4335.

14.   Wen-Xin Fan, Ji-Lin Li, Wen-Xin Lv, Ling Yang, Qingjiang Li and Honggen Wang* Synthesis of Fluorinated Amphoteric Organoborons via Iodofluorination of Alkynyl and Alkenyl MIDA Boronates,  Chem. Commun., 2020, 56, 82 – 85.

15.   Kefeng Wang, Zixi Zhuang , Huihui Ti,* Peishan Wu,* Xin Zhao, Honggen Wang,* Et2Zn-Promoted beta-Trans-Selective Hydroboration of Ynamide, Chinese Chemical Letters, 2020， 31， 1564-1567.

16.   Liu, X.; ‡ Lin, E E.; ‡ Chen, G.; Li, J.-L.; Liu, P.;* Wang, H.* “Radical Hydroboration and Hydrosilylation of gem-Difluoroalkenes: Synthesis of α‑Difluorinated Alkylborons and Alkylsilanes”, Org. Lett. 2019, 21, 8454-8458.

17.   Lin, P.-P.; ‡ Han, X.-L.; ‡ Ye, G.-H.; Li, J.-L.; Li, Q.;* Wang, H.* “Cp*Co(III)-Catalyzed Dearomative [3 + 2] Spiroannulation of 2-Alkenylphenols with Ynamides via C–H Activation”, J. Org. Chem. 2019, 84, 12966-12974.

18.   Tan, D.-H.; Cai, Y.-H.; Zeng, Y.-F.; Lv, W.-X. Yang, L.; Li, Q.; Wang, H.* “Diversity-Oriented Synthesis of α-Functionalized Acylborons and Borylated Heteroarenes via Nucleophilic Ring-Opening of a-Chloroepoxyboronates”Angew. Chem. Int. Ed. 2019, 58, 13784-13788.

19.   Li, J.; Lin. E.; Han, X.-L.; Li, Q.;* Wang, H.* “Synthesis of Fluorinated Imides via Direct Fluorohydroxylation of Ynamides”, Org. Lett. 2019, 21, 4255-4258.

20.   Lin, E. E.; ‡ Wu, J.-Q.; ‡ Schäfers, F.; Su, X.-X.; Wang, K.-F.; Li, J.-L.; Chen, Y.; Zhao, X.; Ti, H.; Li, Q.; Ou, T.-M.; Glorius, F.;* Wang, H.* “Regio- and stereoselective synthesis of tetra- and triarylethenes by N-methylimidodiacetyl boron-directed palladium-catalysed three-component coupling” Commun. Chem. 2019, 2, 34. 

21.   Liu, Y.; Wang H.* “Unified Enantioselective Total Syntheses of (-)-Scholarisine G, (+)-Melodinine E, (-)-Leuconoxine and (-)-Mersicarpine” Chem. Commun. 2019, 55, 3544-3547.

22.   Lv, W.-X.;  Li, Z.;  Lin, E; Li, J.-L.;  Tan, D.-H.;  Cai, Y.-H.; Li, Q.; Wang, H.* “Regio- and Diastereoselective Synthesis of Cyclohexadienylborons via an Intermolecular Diels-Alder Reaction of Alkenyl MIDA Boronates with 2-Pyrones” Chem. Eur. J. 2019, 25, 4058.

23.   Zhou, C.-J.; Gao, H.; Huang, S.-L.; Zhang, S.-S.; Wu, J.-Q.; Li, B.; Jiang, X.*; Wang, H.* “Synthesis of Benzofused N-Heterocycles via Rh(III)-Catalyzed Direct Benzannulation with 1,3-Dienes” ACS Catal. 2019, 9, 556−564.

24.   Lv, W.-X.; ‡ Li, Q.; ‡ Li, J.-L.; Li, Z.; Lin, E.; Tan, D.-H.; Cai, Y.-H.; Fan, W.-X.; Wang, H.* “Migratory gem-Difluorination of Alkenyl MIDA Boronates: Facile Synthesis of α- and β-Difluorinated Alkylborons”, Angew. Chem. Int. Ed. 2018, 57, 16544-16548.

25.   Liu, X.-G.; Zhou, C.-J.; Lin, E; Han, X.-L.; Zhang, S.-S.; Li Q.; Wang, H.* “Decarboxylative Negishi Coupling of Redox-Active Aliphatic Ester with Cobalt Catalysis”, Angew. Chem. Int. Ed. 2018, 57, 13096-13100.

26.   Yang, L.;‡ Fan, W.-X.;‡ Lin, E.; Tan, D.-H.; Li Q.; Wang, H.* “Synthesis of α-CF3 and α-CF2H Amines via Aminofluorination of Fluorinated Alkenes”, Chem. Commun. 2018. 54, 5907-5910. 

27.   Wang, H.;* Zeng, Y.-F.; Lv W.-X.; Tan D.-H. “Synthetic Transformations of Alkenyl MIDA Boronates toward the Efficient Construction of Organoborons”, Synlett 2018, 29, 1415-1420. (invited Synpacts contribution)

28.   Yang, L.;‡ Ji, W.-W.;‡ Lin, E; Li, J.-L.; Fan, W.-X. Li, Q.; Wang, H.* “Synthesis of Alkylated Monofluoroalkenes via Fe-catalyzed Defluorinative Cross-Coupling of Donor Alkenes with gem-Difluoroalkenes” Org. Lett. 2018, 20, 1924–1927.

29.   Tan, D. H.; ‡ Lin, E.; ‡ Ji, W.-W.;  Zeng, Y.-F.; Fan, W.-X.; Li, Q.; Gao, H.;* Wang, H.* “Copper-Catalyzed Stereoselective Defluorinative Borylation and Silylation of gem-Difluoroalkenes” Adv. Syn. Catal. 2018, 360, 1032-1037. 

30.   Zeng, Y.-F.; Ji, W.-W.; Lv, W.-X.; Chen, Y.; Tan, D.-H.; Li, Q.; Wang, H.* “Stereoselective Direct Chlorination of Alkenyl MIDA Boronates: Divergent Synthesis of E and Z α-Chloroalkenyl Boronates” Angew. Chem. Int. Ed. 2017, 56, 14707-14711. 

31.   Chen, S.-Y.; Li, Q.;* Wang, H.* “Manganese(I)-Catalyzed Direct C–H Allylation of Arenes with Allenes” J. Org. Chem. 2017, 82, 11173−11181.

32.   Zhang, S.-S.; ‡ Xia, J.; ‡Wu, J.-Q.; Liu, X.-G.; Zhou, C.-J.; Li. Q.; Huang, S.-L.;* Wang, H.* “Three-Component Catalytic Carboxygenation of Activated Alkenes Enabled by Bimetallic Rh(III)/Cu(II) Catalysis” Org. Lett. 2017, 19, 5868−5871.

33.   Liu, X.-G.; ‡ Gao, H.; ‡ Zhang, S.-S.; Li, Q.; Wang, H.* "N-O Bond as External Oxidant in Group 9 Cp*M(III)-Catalyzed Oxidative C−H Coupling Reactions" ACS Catal. 2017, 7, 5078-5086.

34.   Chen, S.-Y.; Han, X.-L.; Li, Q.;* Chen, Y.; Wang, H.* “Mn(I)-Catalyzed Regio- and Stereoselective 1,2-Diheteroarylation of Allenes via a C-H Activation/Directing Group Migration Cascade” Angew. Chem. Int. Ed. 2017, 56, 9939-9943. (Highlighted in Chin. J. Org. Chem. 2017, 37, 2783-2784.)

35.   Ji, W.-W.; Lin, E.; Li, Q.; Wang, H.* “Heteroannulation enabled by a bimetallic Rh(III)/Ag(I) relay catalysis: application in the total synthesis of aristolactam BII” Chem. Commun., 2017, 53, 5665 – 5668.

36.   Chen, S.-Y.; Li, Q.;*Liu, X.-G.; Wu, J.-Q.; Zhang, S.-S.; Wang, H.* “Polycyclization Enabled by Relay Catalysis: One-Pot Manganese-Catalyzed C-H Allylation and Silver-Catalyzed Povarov Reaction” ChemSusChem, 2017, 10, 2360-2364.

37.   Liu, X.-G.; Li, Q.; Wang, H.* “(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Direct Trifluoromethylthiolation of Arenes via C-H Activation” Adv. Synth. Catal., 2017, 359, 1942-1946.

38.   Wu, J.-Q.; ‡ Zhang, S.-S.; ‡ Gao, H.; ‡Qi, Z.; Zhou, C.-J.; Ji, W.-W.; Liu, Y.; Chen, Y.; Li, Q.; Li, X.;* Wang, H.* “Experimental and Theoretical Studies on Rhodium-Catalyzed Coupling of Benzamides with 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Fluorinated Heterocycles” J. Am. Chem. Soc. 2017, 139, 3537-3545. 

39.   Tan, D.-H.; Zeng, Y.-F.; Liu, Y.; Lv, W.-X.; Li, Q.; Wang, H.* “Direct Assembly of Prenylated Heteroarenes through a Cascade Minisci Reaction/Dehydration Sequence” ChemistryOpen 2016, 5, 535–539.

40.   Liu, Y.; Zhou, C.-J.; Li, Q.;* Wang, H.* “Total synthesis of (±)-ganocins B and C” Org. Biomol. Chem. 2016, 14, 10362-10365. 

41.   Lv, W.-X.;‡ Zeng, Y.-F.;‡ Li, Q.; Chen, Y.; Tan, D.-H.; Yang, L.; Wang, H.* “Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform to Halogenated and Trifluoromethylated α-Boryl Ketones” Angew. Chem. Int. Ed. 2016, 55, 10069-10073.

42.   Lao, Y.-X.; Zhang, S.-S.; Liu, X.-G.; Jiang, C.-Y.; Wu, J.-Q.; Chen, S.-Y.; Li, Q.; Huang, Z.-S.; Wang, H.* “High-Valent Cp*Co(III) or Cp*Ir(III)-Catalyzed C–H Annulation with Alkynes: Straightforward Synthesis of Heterocyclic Quaternary Ammonium Salts. Adv. Synth. Catal., 2016, 358, 2186-2191. 

43.   Zhang, S.-S.; Liu, X.-G.; Chen, S.-Y.; Tan, D.-H.; Jiang, C.-Y.; Wu, J.-Q.; Li, Q.*; Wang, H.* “(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N-H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines” Adv. Synth. Catal., 2016, 358, 1705-1710.

44.   Liu, X.-G.; Zhang, S.-S.; Jiang, C.-Y.; Wu, J.-Q.; Li, Q.; Wang, H.* “Cp*Co(III)-Catalyzed Annulations of 2-Alkenylphenols with CO: Mild Access to Coumarin Derivatives” Org. Lett., 2015,  17, 5404–5407.

45.   Zhang, S.-S.;‡ Jiang, C.-Y.;‡ Wu, J.-Q.; Liu, X.-G.; Li, Q.; Huang, Z.-S.; Li, D.;* Wang, H.* “Cp*Rh(III) and Cp*Ir(III)-catalysed redox-neutral C–H arylation with quinone diazides: quick and facile synthesis of arylated phenols”, Chem. Commun., 2015, 51, 10240-10243.

46.   Lao, Y.-X.; Wu, J.-Q.; Chen, Y.; Zhang, S.-S.; Li, Q.; Wang H.* “Palladium-catalyzed methylene C(sp3)–H arylation of the adamantyl scaffold”, Org. Chem. Front., 2015, 2, 1374-1378. (From themed collection 2015 Emerging Investigators by OCF， Hot Articles in August and September)

47.   Zeng, Y.-F.; Tan, D.-H. Y.; Chen, Y.; Lv, W.-X.;Liu, X.-G.; Li , Q.; Wang, H.* “Direct Radical Trifluoromethylthiolation and Thiocyanation of Aryl Alkynoate Esters: Mild and Facile Synthesis of 3-Trifluoromethylthiolated and 3-Thiocyanated Coumarins”, Org. Chem. Front., 2015, 2, 1511–1515. 

48.   Wu, J.-Q.; ‡ Yang, Z.; ‡ Zhang, S.-S.; Jiang, C.-Y.; Li, Q.; Huang, Z.-S.; * Wang H.* “From Indoles to Carbazoles: Tandem Cp*Rh(III)-Catalyzed C–H Activation/Brønsted Acid-Catalyzed Cyclization Reactions”, ACS Catal., 2015, 5, 6453–6457.

49.   Rao, Y.; Liu, H.; Gao, L.; Yu, H.; Ou, T.-M.; Tan, J.-H.; Huang, S.-L.; Wang, H.; Li, D.; Gu, L.-Q.;  Ye, J.-M.; Huang, Z.-S. “Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment”, J. Med. Chem., 2015, 58, 9395–9413.

50.   Qiu, J.; Wang, M.; Zhang, Y.; Zeng, P.; Ou, T.-M.; Tan, J.-H.; Huang, S.-L.; An, L.-K.; Wang, H.; Gu, L.-Q.; Huang Z.-S.; Li, D. “Biological Function and Medicinal Research Significance of G-Quadruplex”, Curr. Top. Med. Chem., 2015, 15, 1971-1987

51.   Lv, W.-X.; Zeng, Y.-F. Zhang, S.-S.; Li, Q.; * Wang H.* “Mild Mn(OAc)3-Mediated Aerobic Oxidative Decarboxylative Coupling of Arylboronic Acids and Arylpropiolic Acids: Direct Access to Diaryl 1,2-Diketones”, Org. Lett., 2015, 17, 2972–2975.

52.   Liu, X.-G.; Zhang, S.-S.; Wu, J.-Q.; Li, Q.; Wang H.* “Cp∗Co(III)-catalyzed direct functionalization of aromatic C–H bonds with α-diazomalonates”, Tetrahedron Lett., 2015, 56, 4093-4095.

53.   Zeng, Y.-F.; Tan, D.-H.; Lv, W.-X.; Li, Q.; Wang, H.* “Silver-Catalyzed Aerobic Oxidative Decarboxylative Coupling of Arylpropiolic Acids with H-Phosphine Oxides: Mild and Facile Synthesis of β-Ketophosphine Oxides”, Eur. J. Org. Chem., 2015, 4335–4339

54.   Zhang, S.-S.; Wu, J.-Q.; Liu, X.; Wang, H.* “Tandem Catalysis: Rh(III)-Catalyzed C–H Allylation/Pd(II)-Catalyzed N-Allylation Toward the Synthesis of Vinyl-substituted N-Heterocycles”, ACS Catal. 2015, 5, 210-214. 

55.   Wu, J.-Q.; ‡ Qiu, Z.-P.; ‡ Zhang, S.-S.; Liu, J.-G.; Lao, Y.-X.; Gu, L.-Q.; Huang, Z.-S.*; Li, J.*; Wang, H.* “Rhodium(III)-Catalyzed C–H/C–C Activation Sequence: Vinylcyclopropanes as Versatile Synthons in Direct C–H Allylation Reactions”, Chem. Commun., 2015, 51, 77.

56.   Zhang, S.-S.; Wu, J.-Q.; Lao, Y.-X.; Liu, X.; Liu, Y.; Lv, W.-X.; Tan, D.-H.; Zeng, Y.-F.; Wang, H.* “Mild Rhodium(III)-Catalyzed C－H Allylation with 4-Vinyl-1,3-dioxolan-2-ones: Direct and Stereoselective Synthesis of (E)-Allylic Alcohols”, Org. Lett., 2014, 16, 6412–6415.

57.   Cui, W.; Chen, S.; Wu, J.-Q.; Zhao, X.;* Hu, W.;* H. Wang*, “Palladium-Catalyzed Remote C(sp3)–H Arylation of 3-Pinanamine”, Org. Lett., 2014, 16, 4288.

58.   Wang, H.; Beiring, B.; Yu, D.-G.; Collins, K.; Glorius, F. “[3]Dendralene Synthesis: Rhodium(III)-Catalyzed Alkenyl C–H Activation and Coupling Reaction with AllenylCarbinol Carbonate.” Angew. Chem. Int. Ed., 2013, 52, 12430.

59.   Wang, H.; Schröder, N.; Glorius, F. “Mild Rh(III)-Catalyzed Direct C-H Allylation of Arenes with Allyl Carbonates.” Angew. Chem. Int. Ed., 2013, 52, 5386.

60.   Wang, H.; Grohmann, C; Nimphius, C.; Glorius, F.* “Mild Rhodium(III)-Catalyzed C–H Activation and Annulation with Alkyne MIDA Boronates: Short and Efficient Synthesis of Heterocyclic Boronic Acid Derivatives.” J. Am. Chem. Soc., 2012, 134, 19592.

61.   Wang, H.*; Glorius, F.* “Lending Handedness to the Cyclopentadienyl Ligand.” Science, 2012, 338, 479.

62.   Wang, H.; Glorius, F.* “Mild Rhodium(III)‐Catalyzed C-H Activation and Intermolecular Annulation with Allenes” Angew. Chem. Int. Ed., 2012, 51, 7318.

63.   Wang, H.; Wang, Y.; Liang, D.; Zhang, J.*; Zhu, Q.* “Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles.” Angew. Chem. Int. Ed., 2011, 50, 5678.

64.   Wang, H.; Wang, Y.; Peng, C.; Zhang, J.*; Zhu, Q.* “A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines.” J. Am. Chem. Soc., 2010, 132, 13217.

65.   Wang, H.; Zhao, J.; Zhang, J.; Zhu, Q.* “BrønstedAcid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-spiro-3,4-dihydro-2-(1H)-quinazolinones.” Adv. Synth. Catal., 2011, 353, 2653.

66.   Wang, H.; Liu, L.; Wang, Y.; Peng, C.; Zhang, J.*; Zhu, Q.* “An efficient synthesis of 4-alkyl-2(1H)-quinazolinones and 4-alkyl-2-chloroquinazolines from 1-(2-alkynylphenyl)ureas.” Tetrahedron Lett. 2009, 50, 6841-6843.

67.   Grohmann, C.; Wang, H.; Glorius,F.* “Rh[III]-catalyzed C-H Amidation using Aroyloxycarbamates to give N-Boc protected Arylamines.” Org. Lett., 2013, 15, 3014.

68.   Grohmann, C.; Wang, H.; Glorius,F.* “Rh[III]-Catalyzed Direct C–H Amination Using N-Chloroamines at Room Temperature.” Org. Lett., 2012, 14, 656.

69.   Wang, Y.; Wang, H.; Peng, J.; Zhu, Q.* “Palladium-Catalyzed Intramolecular C(sp2)-H Amidination by Isonitrile Insertion: Direct Access to 4-Aminoquinazolines from N-Arylamidines.” Org. Lett., 2011, 13, 4604.

70.   Peng, L.; Wang, H.; Peng, C.; Ding, K.*; Zhu, Q.* “Sequential Hydration-Condensation-Double Cycloaddition of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles.” Synthesis, 2011, 1723.

71.   Wencel-Delord, J.; Nimphius, C.; Wang, H.; Glorius, F.* “Rhodium(III) and Hexabromobenzene – A Catalyst System for the Cross-Dehydrogenative Coupling of Simple Arenes and Heterocycles with Arenes Bearing Directing Groups.” Angew. Chem. Int. Ed., 2012, 51, 13001.

72.   Liu, L.; Wang, Y.; Wang, H.; Peng, C.; Zhao, J.; Zhu, Q.* “Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines.” Tetrahedron Lett. 2009, 50, 6715-6719.

73.   Peng, C.; Wang, Y.; Liu, L.; Wang, H.; Zhao, J.; Zhu, Q.* “p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines.” Eur. J. Org. Chem. 2010, 818-822.

 

 

 

 

書籍與專利情況：

  1. 李清江，張其奇，王洪根，“一種順式二芳基單氟烯烴類化合物的制備方法”，中國專利，201911312557.8.

  2. 王洪根，李清江，呂文心,“偕二氟烷基硼酸酯類化合物及其制備方法和應用”,中國專利：申請号，201811174165.5

  3. 王洪根，劉許歌，李清江，“一種丙克拉莫中間體的合成方法”，中國專利：申請号，201810876659.1

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