簡單介紹
熊小峰 男、博士、教授、博導、院長助理，先後入選國家級高層次青年人才項目、廣東省傑青、珠江青年學者、中山大學“百人計劃”急需青年傑出人才。2003-2012于四川大學華西太阳集团1088vip分别獲得藥學學士和藥物化學博士學位，2017年通過中山大學“百人計劃”回國工作，主要研究領域為基于藥物新靶點的藥物化學和化學生物學研究。先後主持國家自然科學基金面上、青年項目，廣東省傑出青年科學基金、珠江學者項目、丹麥Lundbeck基金、NovoNodisk基金、中山大學“百人計劃”等十餘項科研項目，以第一作者或通訊作者在Nature Chemistry、Angew Chem Int Ed、Chem Sci、J Med Chem、Acta Pharma Sin B、Sci Chin Chem、Eur J Med Chem、Org Lett等期刊發表論文30餘篇。
本課題組尚有2025年博士生及碩士生（學碩+專碩）招生計劃，歡迎聯系。
研究方向
藥物化學
多肽和蛋白質的化學修飾
有機合成化學
教育經曆
2007年9月至2012年7月：理學博士，藥物化學專業，四川大學華西太阳集团1088vip，導師：陳應春教授
2003年9月至2007年7月：理學學士，藥學專業，四川大學華西太阳集团1088vip
工作經曆
2015年1月至2016年11月：助理教授，生物制藥中心，丹麥哥本哈根大學
2012年9月至2015年1月：博士後，丹麥哥本哈根大學，合作導師：Kristian Strømgaard教授
教學情況
藥物化學
藥物合成策略與實例
基礎有機化學實驗
藥學概論
有機化學
科研項目
11. 國家自然科學面上項目，主持，項目編号：82373722，2024.1-2027.12。
11. 廣東省卓越青年團隊，子課題負責人，2023B1515040006，2024.1-2026.12。
10. 國家“萬人計劃”青年拔尖人才項目，項目負責人，2023.1-2025.12。
9. 國家自然科學面上項目，主持，項目編号：22077144，2021.1-2024.12。
8. 中山大學青年教師重點培育項目，主持，項目編号：20ykzd15，2020.1-2021.12。
7. 廣東省傑出青年科學基金，主持，項目編号：2018B030306017，2018.5-2022.4。
6. 國家自然科學青年基金，主持，項目編号：81602972，2017.1-2019.12。
5. 珠江青年學者項目，主持，2018.10-2021.9。
4. 中山大學“百人計劃二期”啟動項目，主持，2017.1-2019.12。
3. 廣州市民生科技攻關專題，子課題負責人，2019.10-2022.9。
2. 丹麥Lundbeck Foundation，主持 ，140萬DKK，2016.10-2018.9。
1. 丹麥NovoNodisk Foundation，主持，110萬DKK，2014.8-2016.9。
學術兼職
1. 《藥學學報》（APSB）中英文兩刊青年編委
2. 《中國化學快報》（Chinese Chemical Letter）青年編委
論文
33. Shumin Ouyang, Shuo Shi, Wen Ding, Yang Ge, Yingxue Su, Jianshan Mo, Keren Peng, Qiyi Zhang, Guopin Liu, Wei Xiao, Peibin Yue, Jinjian Lu, Yandong Wang* Xiaofeng Xiong,* and Xiaolei Zhang*, Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of G𝜶q Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops, Adv Sci, 2024, 2407967.
32. Guangjin Fan; Lu Liu; Jia Ye; Wei Xiao; Xiao-Feng Xiong, Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma, Bioorganic Chemistry, 2024, 143, 107005.
31. Lu Liu; Zhendong Song; Guangjin Fan; Linlin Lou; Yuanxiang Wang; Xiaolei Zhang; Xiao-Feng Xiong, Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling, Bioorganic & Medicinal Chemistry, 2023, 93, 117457.
30. Zhendong Song, Linlin Lou; Guangjin Fan; Lu Liu; Yang Ge; He Liu; Albert S.C. Chan; Xiaolei Zhang; Xiao-Feng Xiong, Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects, European Journal of Medicinal Chemistry, 2023, 245, 114907.
29. Qi-Long Hu, Jia-Tian Liu, Guangjin Fan, Jian Li, Hu, QL;Liu, JT;Fan, GJ;Li, J;Li, YX;Chan, ASC; Xiong, XF, On-resin peptide modification of methionine residue by employing 2-bromoacetate derivatives, Chin Chem Lett, 2023, 34, 198-202.
28. Feng Zhou, Qi-Long Hu, Ke-Qiang Hou,* Hu, QL;Liu, JT;Fan, GJ;Li, J;Li, YX;Chan, ASC;Xiong, XF*, Construction of α,β-Diamino Diacid Derivatives with Adjacent Acyclic Tetrasubstituted Stereocenters, J. Org. Chem., 2022,87, 8709-8718.
27. Feng Zhou, Yue Huang, Lu Liu, Zhendong Song, Ke-Qiang Hou, Yifan Yang, Hai-Bin Luo, Yi-You Huang*, Xiao-Feng Xiong*, Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects, Biochemical Pharmacology, 2022, 202, 115123.
26. Jun-Jie Deng , Lu Liu , Yang Ge, Zhendong Song Jie Huang, Guangjin Fan Xiao-Feng Xiong*, Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma, Eur. J. Med. Chem, 2022, 239, 114520.
25. Yang Ge, Jun-Jie Deng, Jianzheng Zhu, Lu Liu, Shumin Ouyang, Zhendong Song, Xiaolei Zhang*, Xiao-Feng Xiong*, Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma, Acta Pharmaceutica Sinica B, 2022, 12, 3326-3340.
24. Jian Li, Qi-Long Hu, Zhendong Song, Albert S. C. Chan*, Xiao-Feng Xiong*, Cleavable Cys labeling directed Lys-site-selective stapling and single-site modification, Sci. Chin. Chem, 2022, 65, 1356-1361.
23. Zhendong Song, Yi-You Huang, Ke-Qiang Hou, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai-Bin Luo,* and Xiao-Feng Xiong*, Discovery and structural optimization of Toddacoumalone derivatives as novel PDE4 Inhibitors for the topical treatment of Psoriasis, J. Med. Chem. 2022, 65, 4238−4254.
22. Jian Li, Weihong Lai, Ao Pang, Lu Liu, Lianbao Ye, Xiao-Feng Xiong*, On-resin synthesis of linear aryl thioether containing peptides and in-solution cyclization via cysteine S N Ar reaction, Organic Letters, 2022, 24, 1673-1677.
21. Guangjin Fan, Linlin Lou, Zhendong Song*, Xiaolei Zhang*, Xiao-Feng Xiong*, Targeting mutated GTPase KRAS in tumor therapies, Eur. J. Med. Chem, 2021, 226, 113816.
20. Qi-Long Hu, Jia-Tian Liu, Jian Li, Yang Ge, Zhendong Song, Albert S. C. Chan; Xiao-Feng Xiong*, Demethylative alkylation of methionine residue by employing the sulfonium as the key intermediate, Organic Letters, 2021, 23: 8543-8548
19. Yang Ge,§ Shuo Shi,§ Jun-Jie Deng, Xue-Ping Chen, Zhendong Song, Lu Liu, Linlin Lou, Xiaolei Zhang,* Xiao-Feng Xiong*, Design, Synthesis and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma, J. Med. Chem. 2021, 64, 3131-3152.
18. Jian Li, Jun-Jie Deng, Zhibin Yin, Qi-Long Hu, Yang Ge, Zhen-Dong Song, Ying Zhang, Albert S. C. Chan, Huilin Li, and Xiao-Feng Xiong*, Cleavable and Tunable Cysteine-Specific Arylation Modification by Aryl Thioethers, Chemical Science, 2021, 12, 5209-5215.
17. Xue-Ping Chen, Ke-Qiang Hou, Feng Zhou, Albert S. C. Chan, and Xiao-Feng Xiong*, Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4 + 2] Cyclization of 2‑Benzothiazolimines and Aldehydes, J. Org. Chem., 2021, 86, 1667-1675.
16. Zhen-Dong Song, Mei-Jing Wang, Yang Ge, Xue-Ping Chen, Zi-Yang Xu, Yang Sun*, Xiao-Feng Xiong*, Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies, Acta Pharmaceutica Sinica B, 2021, 11, 13-29.
15. Ke-Qiang Hou, Feng Zhou, Xue-Ping Chen, Yang Ge, Albert S.C. Chan and Xiao-Feng Xiong*, Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by Mannich-Type Reaction, J. Org. Chem., 2020, 85, 9661-9667.
14. Qi-Long Hu, Ke-Qiang Hou, Jian Li, Yang Ge, Zhen-Dong Song, Albert S.C. Chan and Xiao-Feng Xiong*, Silanol: A bifunctional group for peptide synthesis and late-stage functionalization, Chemical Science, 2020, 11, 6070-6074。
13. Jun-Xiang Huang, Ke-Qiang Hou, Qi-Long Hu, Xue-Ping Chen, Jian Li, Albert S. C. Chan, and Xiao-Feng Xiong*, Organo-catalytic Asymmetric Three-component Povarov Reactions of Anilines and Aldehydes, Organic Letters, 2020, 22, 1858-1862.
12. Ke-Qiang Hou, Xue-Ping Chen, Yiyou Huang, Albert S. C. Chan, Hai-Bin Luo, Xiao-Feng Xiong*, Asymmetric total synthesis and biological evaluation of the nutural PDE4 inhibitor toddacoumalone. Organic Letters, 2020, 22, 584-588.
11. Jian Li, Qi-Long Hu, Xue-Ping Chen, Ke-Qiang Hou, Albert S.C. Chan*, Xiao-Feng Xiong*, Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an organocatalyzed formal [3+3] annulation of quinolinones and MBH 2-naphthoates of nitroolefifin, Chin. Chem. Lett., 2020, 21, 697-670.
10. Jian Li, Yang Ge, Jun-Xiang Huang, Kristian Strømgaard, Xiaolei Zhang, Xiao-Feng Xiong*,, Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery, J. Med. Chem. 2020, 63, 5013-5020.
9. Xiao-Feng Xiong, Hang Zhang, Michael W. Boesgaard, Christina R. Underwood, Hans Bräuner-Osborne, Kristian Strømgaard, Structure-activity relationship study of natural Gq protein inhibitor YM-254890, ChemMedChem, 2019, 14, 865-870.
8. Xiao-Feng Xiong, Hang Zhang, Christina R. Underwood, Kasper Harpsøe, Thomas J. Gardella, Mie F. Wöldike, Micheal Mannstadt, David. E. Gloriam, Hans Bräuner-Osore, Kristian Strømgaard. “Total synthesis and structure-activity relationship study of a series of selective Gq protein inhibiotrs “. Nature Chemistry. 2016, 8, 1035-1041.
7. Xiao-Feng Xiong, Mette H. Poulsen, Rama Ashraf, Niels G. Nørager, Kristian Strømgaard, “Structure-activity relationship study of spider polyamine toxins as inhibitors of ionotropic glutamate receptors“. ChemMedChem, 2014, 9, 2661-2670. 封面文章
6. Xiao-Feng Xiong, Quan Zhou, Jing Gu, Lin Dong, Tan-Yu Liu, Ying-Chun Chen, “Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels-Alder Reaction”, Angew. Chem. Int. Ed. 2012, 51, 4401-4404. VIP及封面文章
5. Xiao-Feng Xiong, Hang Zhang, Jing Peng, and Ying-Chun Chen, “Direct Asymmetric Michael Addition of cyclic N-sulfonylimines to α,β-Unsaturated Aldehydes”, Chem. Eur. J. 2011, 17, 2358-2360.
4. Xiao-Feng Xiong, Zhi-Jun Jia, Wei Du, Kun Jiang, Tian-Yu liu, Ying-Chun Chen, “Merging chiral organocatalysts: enantio- and diastereoselective directvinylogous Mannich reaction of alkylimines”, Chem. Commun. 2009, 6994-6996.
3. Kelly L Roszko, Bi Ruiye, Caroline Gorvin, Hans Bräuner-Osborne, Xiao-Feng Xiong, Asuka Inoue, Rajesh V Thakker, Kristian Strømgaard, Thomas Gardella, Michael Mannstadt, "Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors", JCI Insight, 2017, 2(3):e91079. doi:10.1172/jci.insight.91079
2. Hang Zhang, Xiao-Feng Xiong, Michael W. Boesgaard, Christina R. Underwood, Hans Bruner-Osborne, and Kristian Strømgaard. "Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein", ChemMedChem, 2017, DOI: 10.1002/cmdc.201700155.
1. Bo Han, Qing-Ping Liu, Rui Li, Xu Tian, Xiao-Feng Xiong, Jing-Gen Deng, Ying-Chun Chen, “Discovery of Bifunctional Thiourea/Secondary-Amine Organocatalysts for the Highly Stereoselective Nitro-Mannich Reaction of α-Substituted Nitroacetates”, Chem. Eur. J. 2008，14 , 8094-8097.
書籍和專利
1. Polyamine toxins from spiders and wasps, Xiao-Feng Xiong, Kristian Strømgaard, 2015, Polyamiens: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, 201-214.
2. 《藥物化學》在線試題庫，國家級規劃教材，鄧衛平、尤啟東...熊小峰等，2021， ISBN 978-7-122-37883-5。
3.一種四氫咪唑[1,2-a]吡嗪類化合物、組合物及其制備方法與應用，熊小峰；張小雷；葛陽；石碩；鄧俊傑；劉璐；陳新滋；授權号：ZL202011327191.4
4.一種Toddacoumalone 類化合物或其藥學上可接受的鹽及其制備方法和應
用，熊小峰；侯克強；陳雪萍；黃俊翔；授權号：ZL201910779476.
5.一種環酯肽類 Gq 蛋白抑制劑及其制備方法和應用，熊小峰；李堅；胡啟龍；黃俊翔；申請号：201910779900.3
6.一種喹啉酮骨架的PDE4 抑制劑及其制備方法與應用，熊小峰；宋振東；羅海彬；黃儀有；劉璐；侯克強；申請号：202111543984.4
7.一種寡核苷酸 RNA 雙鍊分子及其在制備治療惡性腫瘤藥物中的應用，張小雷；劉培慶；熊小峰；朱劍征；歐陽淑敏；石碩；葛陽；申請号：202111034572.8
誠聘特聘研究員、博士後。除正常薪資外，課題組将每年提供額外津貼。歡迎具有化學、藥學或生物學背景的同學加入本課題組。