翁江，男，1982年11月生，博士，副教授，博士生導師。主要研究領域為藥物合成化學和有機合成化學。先後承擔國家自然科學基金、廣東省自然科學基金重等多項基金項目，在國内外重要學術期刊上發表高水平論文50餘篇，申請和獲得授權發明專利4項。
2024年招收專業型碩士生2名，歡迎考生聯系報考。
聯系方式
辦公電話：020-39943046
E-mail: wengj2@mail.sysu.edu.cn
研究方向
不對稱催化和手性技術
手性藥物的高效合成
活性天然産物的全合成
自由基化學
學習和工作經曆
2012/7-至今，太阳集团1088vip，曆任講師和副教授
2017/12-2018/12，美國Scripps研究所，訪問學者
2010/07 – 2012/07，太阳集团1088vip，博士後
2007/09 – 2010/06，太阳集团1088vip，有機化學專業，博士
2005/09 – 2007/06，中山大學化工學院，有機化學專業，碩士
2001/09 – 2005/06，湖北大學化材學院，應用化學專業，學士
教學情況
有機化學；有機化學實驗
科研項目
近年主持的縱向科研項目：
1. 國家自然科學基金-青年科學基金項目：環戊烯酮類前列腺素的合成新方法及其靶向白血病幹細胞活性研究；21502240；2016.1-2018.12；
2. 廣東省自然科學基金項目-面上項目：基于有機催化串聯反應構建環狀DPP-4抑制劑及其降血糖活性研究；2015A030313130；2015.8.1-2018.8.1；
3. 廣東省自然科學基金項目-博士啟動項目：有機催化串聯Michael/Wittig/Aldol反應及其在前列腺素合成中的應用；S2013040012409；2013.10-2015.10；
4. 廣東省醫學科學基金項目：前列腺素F的高效合成新方法研究；A2015167；2015.7-2017.6；
5. 中央高校基本科研業務費-中山大學青年教師培育計劃項目：2012.11-2015.11；
6. 中山大學青年教師起步資助計劃；2012.12-2013.12
論著專利
發表論文：
37. Wang, Sheng-Cai; Zhou, Xiang; Li, Ying-Xian; Zhang, Chun-Yan; Zhang, Zi-Yan; Xiong, Yan-Shi*; Lu, Gui; Dong, Jiajia*; Weng, Jiang*. Enabling Modular Click Chemistry Library through Sequential Ligations of Carboxylic Acids and Amines. Angew. Chem., Int. Ed. 2024, 63, e202410699.
36. Xiong, Ting; Chen, Qi-Long; Zhang, Zi-Yan; Lu, Gui*; Weng, Jiang*. Direct Fluorosulfonamidation of (Hetero)arenes and Alkenes with Photoredox-Active Fluorosulfamoyl Radical Reagents. ACS Catal. 2024, 14, 12082-12092.
35. Xiong, Ting; Hu, Zi-Jun; Wang, Ya-Qi; Weng, Jiang* Enhanced Synthesis of Sulfonyl Fluorides and Sulfamoyl Fluorides Using Fluorosulfonyl-Containing Radical Reagents. Synthesis, 2024, DOI: 10.1055/a-2446-8046. (Invited review, Special issue on SuFEx Chemistry)
34. Zhu, Wen-Run; Su, Qiong; Deng, Xiao-Yi; Ouyang, Ze-Long; Weng, Jiang*; Lu, Gui* Organocatalytic asymmetric cascade bicyclization: access to chiral polycyclic bisindoles from 2-indolylmethanols and propargylic alcohols. Org. Chem. Front. 2024, 11, 2040-2046.
33. Ting Xiong, Qi-Long Chen, Zhi-Da Chen, Ji-Tao Yi, Sheng-Cai Wang, Gui Lu,* Albert S.C. Chan, and Jiang Weng*. Switchable carbo-fluorosulfonylation and hydro-fluorosulfonylation of alkenes enabled by bifunctional fluorosulfonyl radical precursors. Chem Catal. 2023, 3, 100821.
32. Jing Guo, Ying Xie, Ze-Min Lai, Jiang Weng*, Albert S. C. Chan, and Gui Lu*. Enantioselective hydroalkylation of alkenylpyridines enabled by merging photoactive electron donor–acceptor complexes with chiral bifunctional organocatalysis. ACS Catal. 2022, 12, 13065-13074.
31. Ji-Tao Yi, Xiang Zhou, Zhi-Da Chen, Qi-Long Chen, Gui Lu,* Jiang Weng.* Copper-catalyzed direct decarboxylative fluorosulfonylation of aliphatic carboxylic acids. Chem. Commun., 2022, 58, 9409-9412. (Highlighted by SYNFACTS, 2022, 18, 1806.)
30. Zhi-Da Chen, Xiang Zhou, Ji-Tao Yi, Hong-Juan Diao, Qi-Long Chen, Gui Lu, Jiang Weng.* Catalytic decarboxylative fluorosulfonylation enabled by energy-transfer-mediated photocatalysis. Org. Lett. 2022, 24, 2474-2478. (Selected as Front Cover)
29. Wen-Run Zhu, Qiong Su, Xiao-Yi Deng, Jia-Sheng Liu, Tao Zhong, Shan-Shui Meng, Ji-Tao Yi, Jiang Weng,* Gui Lu.* Organocatalytic enantioselective SN1-type dehydrative nucleophilic substitution: access to bis(indolyl)methanes bearing quaternary carbon stereocenters. Chem. Sci. 2022, 13, 170-177.
28. Tao Zhong, Ji-Tao Yi, Zhi-Da Chen, Quan-Can Zhuang, Yong-Zhao Li, Gui Lu, Jiang Weng.* Photoredox-catalyzed aminofluorosulfonylation of unactivated olefins. Chem. Sci. 2021, 12, 9359-9365.
27. Tao Zhong, Zhi-Da Chen, Ji-Tao Yi, Gui Lu,* Jiang Weng.* Recent progress in the synthesis of sulfonyl fluorides for SuFEx click chemistry. Chin. Chem. Lett. 2021, 32, 2736-2750.
26. Tao Zhong, Meng-Ke Pang, Zhi-Da Chen, Bin Zhang, Jiang Weng,* Gui Lu. Copper-free Sandmeyer-type Reaction for the Synthesis of Sulfonyl Fluorides. Org. Lett. 2020, 22, 3072-3078.
25. Wen-Run Zhu, Qiong Su, Hong-Juan Diao, Er-Xuan Wang, Feng Wu, Yun-Long Zhao, Jiang Weng,* Gui Lu.* Enantioselective Dehydrative gamma-Arylation of alpha-Indolyl Propargylic Alcohols with Phenols: Access to Chiral Tetrasubstituted Allenes and Naphthopyrans. Org. Lett. 2020, 22, 6873-6878.
24. Wen-Run Zhu, Kai Liu, Jiang Weng,* Wei-Hua Huang, Wei-Jie Huang, Qing Chen, Ning Lin,* Gui Lu.* Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines. Org. Lett. 2020, 22, 5014-5019
23. Jing Guo, Ying Xie, Wen-Tian Zeng, Qiao-Lei Wu, Jiang Weng,* Gui Lu.* Visible-Light Catalyzed [1+2+2] Cycloaddition Reactions Enabled by the Formation of Methylene Nitrones. Adv. Synth. Catal. 2020, 362: 5450-5456.
22. Wei-Hua Huang, Gong-Bin Huang, Wen-Run Zhu, Jiang Weng,* Gui Lu.* Transition Metal-free Synthesis of α-Aryl Ketones via Oxyallyl Cation Capture with Arylboronic Acids. Org. Chem. Front. 2020, 7, 2480-2485.
21. Hang Shi, Yi Lu, Jiang Weng, Katherine L. Bay, Xiangyang Chen, Keita Tanaka, Pritha Verma, Kendall N. Houk,* Jin-Quan Yu.* Differentiation and functionalization of remote C-H bonds in adjacent positions. Nature Chem. 2020, 12, 399-404.
20. Yan-Shi Xiong, Bin Zhang, Yang Yu, Jiang Weng,* Gui Lu.* Construction of sulfonyl phthalides via copper-catalyzed oxysulfonylation of 2-vinylbenzoic acids with sodium sulfinates. J. Org. Chem. 2019, 84, 13465-13472.
19. Guoqin Xia, Jiang Weng, Luoyan Liu,Pritha Verma, Ziqi Li, Jin-Quan Yu.* Reversing conventional site-selectivity in C(sp3)-H bond activation. Nature Chem. 2019, 11, 571-577.
18. Jing Guo, Gong-Bin Huang, Qiao-Lei Wu, Ying Xie, Jiang Weng,* Gui Lu.* An efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction. Org. Chem. Front. 2019, 6, 1955-1960.
17. Gong-Bin Huang, Wei-Hua Huang, Jing Guo, Xu Dong-Liang, Xiao-Chen Qu, Pei-Hong Zhai, Xiu-Hua Zheng, Jiang Weng,* Gui Lu.* Enantioselective synthesis of triarylmethanes via organocatalytic 1,6-addition of arylboronic acids to para-quinone methides. Adv. Synth. Catal. 2019, 361, 1241-1246.
16. Yan-Shi Xiong, Jiang Weng,* Gui Lu.* Manganese(III)-mediated and -catalyzed decarboxylative hydroxysulfonylation of arylpropiolic acids with sodium sulfinates in water. Adv. Synth. Catal. 2018, 360, 1611-1616.
15. Jing Guo, Qiao-Lei Wu, Ying Xie, Jiang Weng,* Gui Lu.* Visible-light-mediated decarboxylative benzylation of imines with arylacetic acids. J. Org. Chem. 2018, 83, 12559-12567.
14. Yan-Shi Xiong, Yang Yu, Jiang Weng,* Gui Lu.* Copper-catalyzed peri-selective direct sulfenylation of 1-naphthylamines with disulfides. Org. Chem. Front. 2018, 5, 982-989.
13. Jun-Ming Li, Yong-Heng Wang, Yang Yu, Ruibo Wu, Jiang Weng,* Gui Lu.* Copper-catalyzed remote C–H functionalizations of naphthylamides through coordinating activation strategy and single-electron-transfer (SET) mechanism. ACS Catalysis, 2017, 7, 2661-2667.
12. Jing Guo, Zi-Hui Lin, Kai-Bin Chen, Ying Xie; Albert S. C.Chan, Jiang Weng,* Gui Lu.* Asymmetric amination of 2-substituted indolin-3-ones catalyzed by natural cinchona alkaloids. Org. Chem. Front. 2017, 4, 1400-1406.
10. Wei-Jie Huang, Qing Chen, Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Yan-Shi Xiong, Jiang Weng*, Gui Lu* Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions. Org. Chem. Front., 2017, 4, 472-482.
9. Can Liu, Jiang Weng*, Zi-Hui Lin, Wei-Jie Huang, Jing Guo, Lin-Jie Huang, Gui Lu*, Asymmetric synthesis of vicinal amino alcohols via organocatalytic sequential α-amination/Grignard addition reactions of aldehydes. Tetrahedron: Asymmetry, 2017, 28, 41-46.
8. Ji-Quan Zhang, Yong-Jie Luo, Yan-Shi Xiong, Yang Yu, Zheng-Chao Tu, Zi-Jie Long, Xiao-Ju Lai, Hui-Xuan Chen, Yu Luo, Jiang Weng, Gui Lu. Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors. J. Med. Chem. 2016, 59, 7268–7274.
7. Jun-Ming Li, Jiang Weng,* Gui Lu, Albert S.C. Chan. Copper-catalyzed C5-regioselective C-H sulfonylation of 8-aminoquinoline amides with aryl sulfonyl chlorides. Tetrahedron Lett., 2016, 57, 2121-2124.
6. Jing Guo, Jiang Weng,* Gong-Bin Huang, Lin-Jie Huang, Albert S. C. Chan, Gui Lu.* Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3'-biindoles. Tetrahedron Lett., 2016, 57, 5493-5496.
5. Jiang Weng,* Sheng Wang, Lin-Jie Huang , Zhang-Yi Luo, Gui Lu.* Stereoselective Synthesis of Epoxyisoprostanes: An Organocatalytic and "Pot-economy" Approach. Chem. Commun. 2015, 51, 10170-10173. (Highlighted by Organic Chemistry Portal)
4. Lin-Jie Huang, Jiang Weng,* Sheng Wang, Gui Lu.* Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles. Adv. Synth. Catal. 2015, 357(5), 993-1003. (Highlighted by X-MOL)
3. Jiang Weng, Jun-Ming Li, Feng-Quan Li, Zhi-Sheng Xie, Gui Lu.* Asymmetric domino nitro-Michael/Horner-Wadsworth-Emmons reaction for disubstituted cyclohexenecarboxylate annulation: efficient synthesis of DPP-4 inhibitor ABT-341 and influenza neuraminidase inhibitors. Adv. Synth. Catal., 2012, 354, 1961-1970.
2. Jiang Weng, Yong-Bo Li, Rui-Bin Wang, Gui Lu. Organocatalytic Michael reaction of nitroenamines with aldehydes: efficient asymmetric synthesis of (−)-oseltamivir. ChemCatChem, 2012, 4, 1007-1012. (Invited paper)
1. Jiang Weng, Yong-Bo Li, Rui-Bin Wang, Feng-Quan Li, Can Liu, Albert S. C. Chan, Gui Lu. A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate. J. Org. Chem., 2010, 75, 3125-3128. (Highlighted by SYNFACTS, 2010, 8, 857)
1. Process for the preparation of 1-nitro-4-oxobutanylamides. European Patent application, EP 11164806.9. Juraj Rehak, Gui Lu, Julius Durmis, Jiang Weng, Henrich Brath, Yong-Bo Li, Martin Hutka, Stefan Toma, Attila Latika. （歐洲發明專利）
2. 一種具有流感病毒神經胺酸酶抑制活性的環己烯衍生物的制備，中國發明專利。 201110257557.X. 發明人：魯桂、黎逢權、翁江、李勇波
3. 一種3，3’-雙 吲哚化合物的制備方法，中國發明專利。申請号：201610133055.9 發明人：翁江、魯桂、郭靖
■ 申請專利：
1. 一種醋酸阿比特龍酯的制備方法，中國發明專利。申請号：201410426938.X. 發明人：翁江、魯桂、黃琳傑、王堯