聯系方式

辦公電話：020-39943034-808

電子郵箱：jinjing@mail.sysu.edu.cn

辦公地址：廣州大學城外環東路132号太阳集团1088vip，510006

 

簡單介紹

金晶，女，博士，太阳集团1088vip副教授，碩士生、博士生導師。先後于華中科技大學和中山大學獲得藥學學士、藥劑學碩士和藥理學博士學位。目前主要從事藥理與毒理學的教學與研究工作。近年來，作為項目負責人主持國家自然科學基金4項，以及省市級科研項目8項，作為課題骨幹參加國家重點研發計劃和重大新藥創制等項目。近年來，以第一/通訊作者在國内外重要學術期刊雜志上發表高水平收錄論文近50餘篇，獲國家授權專利2項，實現中藥新藥專利成果轉化1項。任國家自然科學基金同行評審專家；任多種藥理與毒理學國際學術期刊特邀審稿人和學術團體委員。

獲獎情況：中國藥理學會-青年藥理學家獎（2016），“廣東省特支計劃”百千萬工程青年拔尖人才（2017），劉昌孝院士人才獎（2018）

（熱忱歡迎報讀本組碩士、博士研究生，也非常歡迎博士後等優秀科研人員加入）

 

研究興趣

1. 中藥藥理與毒理學研究

2. 靶器官急慢性毒性損傷機制及幹預

 

教育經曆

1997年9月-2001年6月   華中科技大學，藥學，本科

2001年7月-2004年6月   華中科技大學，藥劑學，碩士

2007年9月-2010年6月   中山大學，藥理學，博士

 

工作經曆

2004年7月-2010年12月，太阳集团1088vip，助教

2011年1月-2015年12月，太阳集团1088vip，講師

2016年1月-今，太阳集团1088vip，副教授

 

科研項目（主持）

1.     國家自然科學基金，面上項目，2023/01-2026/12，項目負責人

2.     國家自然科學基金，面上項目，2020/01-2023/12，項目負責人

3.     國家自然科學基金，面上項目，2016/01-2019/12，項目負責人

4.     國家自然科學基金，青年基金，2012/01-2014/12，項目負責人

5.     廣東省自然科學基金，面上項目，2024/01-2026/12，項目負責人

6.     廣東省自然科學基金，面上項目，2020/01-2022/12，項目負責人

7.     廣東省自然科學基金，面上項目，2021/01-2023/12，項目負責人

8.     廣東省科技計劃項目，2017/01-2019/12，項目負責人

9.     中山大學青年教師培育計劃，2016/01-2018/12，項目負責人

10.   廣東省醫學科研基金面上項目，2012/6-2015.6，項目負責人

11.   廣東省中醫藥局科研基金面上項目，2015/01-2016/12，項目負責人

12.   橫向課題：系列保健産品的毒性評價，2019-2025，項目負責人

 

社會/學術任職

1. 廣東省藥理學會藥物毒理學專委會  副主任委員

3. 廣東省藥理學會臨床藥理專委會  常務委員

4. 廣東省藥理學會藥物代謝專委會  常務委員

2. 中國藥理學會表觀遺傳藥理學專業委員會  委員

5. 廣東省藥理學會藥物篩選與評價專委會  委員

6. 廣東GLP與藥理毒理評價專委會  委員

7. 中國藥理學會藥物代謝青委會  委員

 

教學工作

講授《藥物毒理學》、《藥學分子生物學》、《生物化學與基礎分子生物學實驗》、《藥代動力學實驗》等藥學本科課程

參編《藥物毒理學》、《生物化學與基礎分子生物學實驗》、《藥代動力學實驗》等教材

 

論著（近年來文章）

  1. Jiang SQ, Nong TL, Yu T, Qin ZY, Huang JY, Yin ZK, Luo SQ, Lai YT, Jin J*, Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics, Environment International, 2025, 198:109390.
  2. Zeng W, Sun MJ, Cao JM, Chen CX, Jiang SQ, Wang YY, Yang WQ, Zhao ZX*, Jin J*, Triterpenoids from ilicis rotundae cortex ameliorate hyperlipidemia by affecting bile acids-hepatointestinal FXR axis, Phytomedicine, 2025,139:156537.
  3. Cao L, Qin ZY, Yu T, Bai XP, Jiang SQ, Wang DF, Ning FQ, Huang M, Jin J*, Tanshinone IIA acts as a regulator of lipogenesis to overcome osimertinib acquired resistance in lung cancer, Biochemical Pharmacology, 2024, 224:116207. doi: 10.1016/j.bcp.2024.116207
  4. Xu JY, Lu LQ, Jiang SQ, Qin ZY, Huang JY, Huang M, Jin J*, Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota, European Journal of Pharmacology, 2024, 971:176516. doi: 10.1016/j.ejphar.2024.176516.
  5. Zhang L, Xu CC, Huang JY, Jiang SQ, Qin ZY, Cao L, Tan GY, Zhao ZX, Huang M, Jin J*. Tanshinone IIA reverses gefitinib resistance in EGFR-mutant lung cancer via inhibition of SREBP1-mediated lipogenesis. Phytotherapy Research, 2024, doi: 10.1002/ptr.8130.
  6. Zhang L, Lu LQ, Jiang SQ, Yin ZK, Tan GY, Ning FQ, Qin ZY, Huang JY, Huang M, Jin J*. Salvianolic acid extract prevents Tripterygium wilfordii polyglycosides-induced acute liver injury by modulating bile acid metabolism. Journal of Ethnopharmacology, 2024, 19:117939.
  7. Qin ZY, Song JX, Huang JY, Jiang SQ, Zhang GY, Huang M, Huang ZY, Jin J*, Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2, Phytomedicine, 2023, 118: 154945.
  8. Qin ZY, Zhang GY, Jiang SQ, Ning FQ, Zhao ZX, Huang M, Jin J*, Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury, Journal of Ethnopharmacology, 2023, 304:116055.
  9. Zhang L, Jiang SQ, Guan ZH, Huang JY, Yin ZK, Tan GY, Wang YY, Zhao ZX, Huang M, Jin J*, Effect of Salvia miltiorrhiza Bunge extracts on improving the efficacy and reducing the toxicity of Tripterygium wilfordii polyglycosides in the treatment of rheumatoid arthritis, Journal of Ethnopharmacology, 2023, 317:116785.
  10. Tan GY, Qin ZY, Jiang SQ, Zhang L, Zhang GY, Huang M, Huang ZY, Jin J*, MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells, Toxicology in Vitro, 2023, 86:105487.
  11. Chen J, Cao D, Jiang SQ, Liu X, Pan WC, Cui H, YangWQ, Liu ZQ, Jin J*, Zhao ZX*, Triterpenoid saponins from Ilex pubescens promote blood circulation in blood stasis syndrome by regulating sphingolipid metabolism and the PI3K/AKT/eNOS signaling pathway, Phytomedicine, 2022, 104:154242.
  12. Xu CC, Zhang L, Wang DF, Jiang SQ, Cao D, Zhao ZX, Jin J*, Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer, Cell Death Discovery, 2021, 7:353.
  13. Jiang SQ, Shen XT, Xuan SX, Yang B, Ruan QF, Cui H, Zhao ZX*, Jin J*, Serum and colon metabolomics study reveals the anti-ulcerative colitis effect of Croton crassifolius Geisel, Phytomedicine, 2021, 87:153570.
  14. Cao L, Hong WP, Xu CC, Bai XP, Zhao ZX, Huang M, Jin J*. Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase, European Journal of Pharmacology, 2021, 890:173647.
  15. Yang B, Xuan SX, Ruan QF, Jiang SQ, Cui H, Zhu LP, Luo X, Jin J*, Zhao ZX*. UPLC/Q-TOF-MS/MS-based metabolomics revealed the lipid-lowering effect of Ilicis Rotundae Cortex on high-fat diet induced hyperlipidemia rats. Journal of Ethnopharmacology, 2020,256: 112784.
  16. Wang DF, Yu WB, Cao L, Xu CC, Tan GY, Zhao ZX, Huang M*, Jin J*, Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats, Biopharmceutics & Drug Disposition, 2020, 41(1-2):54-63.
  17. Chen YB, Zhou ZY, Li GM, Xiao CX, Yu WB, Zhong SL*, Cai YF*, Jin J*, Huang M, Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients, Acta Pharmacologica Sinica, 2019, 40(6):762-768.
  18. Yu WB, Xu CC, Li GM, Hong WP, Zhou ZY, Xiao CX, Zhao YQ, Cai YF, Huang M, Jin J*. Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients. Journal of Pharmaceutical and Biomedical Analysis, 2018, 152(4): 179-187.
  19. Cao D, Xu CC, Xue YY, Ruan QF, Yang B, Liu ZQ, Cui H, Zhang L, Zhao ZX*, Jin J*. The therapeutic effect of Ilex pubescens extract on blood stasis model rats according to serum metabolomics. Journal of Ethnopharmacology, 2018,227:18-28.
  20. Hong WP, Cai PH, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*, Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System. Frontiers in Pharmacology, 2018, 9:43.
  21. Bai XP, Hong WP, Cai PH, Chen YB, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*. Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Toxicology and Applied Pharmacology, 2017, 324(6): 12-25.
  22. Bai XP, Chen YB, Hou XY, Huang M*, Jin J*. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metabolism Reviews. 2016, 48(4):541-567.
  23. Chen XM, Zhao ZX, Chen YB, Gou XL, Zhou ZY, Zhong GP, Cai YF, Huang M, Jin J*. Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology. 2016, 192:362-369.
  24. Hou XY, Bai XP, Gou XL, Zeng H, Xia C, Zhuang W, Chen XM, Zhao ZX, Huang M, Jin J*. 3',4',5',5,7-Pentamethoxyflavone sensitizes cisplatin-resistant A549 cells to cisplatin by inhibition of Nrf2 pathway, Molecules and Cells, 2015, 38(5): 396-401.
  25. Jin J, Sun XZ, Zhao ZX, Wang WW, Qiu YW, Fu XL, Huang M, Huang ZY*. Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity. Phytomedicine, 2015, 22(10):894-901.
  26. Jin J, Li M., Wang WW, Sun XZ, Li J, Zhao ZX, Huang M, Huang ZY*. Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine, 2015, 22(5):528-535.
  27. Wang WW, Guan CW, Sun XZ, Zhao ZX, Li J, Fu XL, Qiu YW, Huang M, Jin J*, Huang ZY*. Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine, 2016，23：589-596.