聯系方式

辦公電話:020-39943043

電子郵箱:zhaozhm2@mail.sysu.edu.cn

辦公地址:

簡單介紹

趙志敏,2005-2010年在日本廣島大學攻讀藥學碩士與博士課程,20103月獲得藥學博士學位。在日期間主要的研究方向是日本沖繩産植物的天然活性成分的提取分離,結構解析及結構修飾和相關的藥理活性研究。201010月于太阳集团1088vip生藥學及天然藥物化學研究室從事留學回國博士後研究工作。20131月留校任講師。主要從事中草藥的活性成分研究。近年來對砂仁、肉桂、桂枝、陳皮、玉金花、野木瓜、七葉蓮、印度菝葜、粗葉懸鈎子、流蘇金石斛、無患子和假煙葉等中草藥的化學成分及生物活性進行了系統的研究。共發表文章30餘篇,其中第一作者或通訊作者包括共同通訊作者發表高水平文章20餘篇。主持2項國家基金和3項省部級基金,并作為主要參與者(總項目排名第七,課題一排名第一參與人)參與國家重點研發項目一項,主持校級項目及橫向5項,作為第一參與人參與省級科研項目及橫向8項,參加國際性學術會議并做口頭彙報多次。研究領域為中草藥質量标準研究,天然産物活性機制研究,活性物質基礎研究以及中藥資源研究等。導師性格開朗,和藹可親,态度溫和,平易近人,對待學生公平公正。熱愛生活,與時俱進,善于學習,對學生負責,要求學生養成良好的學習習慣,培養學生獨立思考問題,解決問題的能力。教育培養學生理念為堅持以身作則,行動為先;堅持關愛學生且有耐心;堅持尊重學生,公平公正且寬容。

科研項目

  1. 2021年國家自然基金基于TLR4/NF-kappaB信号通路金粟蘭屬藥用植物中抗炎免疫的物質基礎和作用機制研究,課題編号:8207373555萬,起始時間2021.1-2024.12.31
  2. 國家自然基金青年基金:南藥春砂仁“和胃”物質基礎及其分子機制的研究,課題編号81102782,趙志敏(主持人),起始時間2012年01月-2014年12月,實際完成時間2014年12月。(24萬元)
  3. 中國博士後科學基金第50批面上資助:基于乳酸脫氫酶-A靶标無患子皂苷抗腫瘤物質基礎及其分子機制研究,課題編号2011M501368,趙志敏(主持人),起始時間2012年01月-2013年12月,實際完成時間2013年12月。3萬元)
  4. 廣東省自然科學基金:金粟蘭屬植物及己中具有抗炎活性的烏藥烷型倍半萜的發現、結構優化及活性研究,趙志敏(主持人),起始時間2018年05月-2021年04月。(10萬元)
  5. 廣州市科技計劃項目:基于高通量轉錄組測序研究烏藥烷型倍半萜抗炎的作用機制,趙志敏(主持人),起始時間2019年04月-2022年03月。(20萬元)
  6. 2017年國家重點研發計劃:南藥(陽春砂、廣陳皮與巴戟天)規模化生态種植及其精準扶貧示範研究,課題編号:2017YFC1701100,楊得坡,張麗霞,鄭國棟,丁平,劉鄂湖,周路山,趙志敏(總項目排名第7,課題1第一項目骨幹)起始時間2017年12月-2021年11月。(48萬/767萬)

論著專利

 1. Bai Bai#, Shao-xia Ye, De-po Yang, Long-ping Zhu, Gui-hua Tang, Yun-yun Chen, Geroge Qian Li, and Zhi-min Zhao*. Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus. Journal of Natural Products, 2019, 82, 407-411.

2. Jiao LinWang ShengqiZheng YifengWang NengYang BowenWang DongmeiYang DepoMei WenjieZhao Zhimin*Wang Zhiyu*Biochemical Pharmacology2019161149-162. 

3. Shaoxia Ye#, Qiyao Zheng, Yang Zhou, Bai Bai, Depo Yang and Zhimin Zhao*, Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway, Molecules,2019, 24(20), E3731.

Bai Bai, Shao-Xia Ye, De-Po Yang, Long-Ping Zhu, Gui-Hua Tang, Yun-Yun Chen, George-Qian Li, Zhi-Min Zhao*, Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus, Journal of Natural Products, DOI: 10.1021/acs.jnatprod.8b00418, 2018. .Thomson Reuters JCR期刊分區: pharmacology &pharmacy Q1

4. Jing-Jun Zhao, Yan-Qiong Guo, De-Po Yang, Xue Xue, Qin Liu, Long-Ping Zhu, Sheng Yin*, Zhi-Min Zhao*(共同通訊作者), Chlojaponilactone B from Chloranthus japonicus: Suppression ofInflammatory Responses via Inhibition of the NF-κB Signaling Pathway, Journal of Natural Products,2016, 79 (9), pp 2257–2263, September 2, 2016.Thomson Reuters JCR期刊分區: pharmacology &pharmacy Q1

5. Hang Li,Jingjun Zhao, Jinlong Chen, Longping Zhu, Dongmei Wang, Jin Jiang, Depo Yang*, Zhimin Zhao*(共同通訊作者), Diterpenoids from Aerial Parts of Flickingeria fimbriata and Their Nuclear factor-kappaB Inhibitory Activities, Phytochemistry, 2015, 117, pp 400-409, September, 2015.Thomson Reuters JCR期刊分區: Plant Sciences Q1

6. Zhi-Min Zhao(第一作者), Zhang-Hua Sun, Mei-Hui Chen, Qiong Liao, Ming Tan, Xin-Wen Zhang, Han-Dong Zhu,Rong-Biao Pi, Sheng Yin*,Neuroprotective polyhydroxypregnane glycosides from Cynanchum otophyllum, Steroids, 2013, 78(10), pp 1015-1020, OTC 2013Thomson Reuters JCR期刊分區: Q3.

7. Hang Li, Shiyi Peng, Depo Yang, Bai Bai, Longping Zhu, Chunyou Mu, Yijing Tian, Dongmei Wang, Zhimin Zhao* (通訊作者). Enantiomeric Meolignans and a Sesquiterpene from Solanumerianthum and Their Absolute Configuration Assignment. Chirality,2016, 28 (3), pp259-263, MAR 2016Thomson Reuters JCR期刊分區: Chemistry, analytical Q2,

8. XueXue, Depo Yang, Dongmei Wang, Xinjun Xu, Longping Zhu, Zhimin Zhao*(通訊作者), Solidification of floating organic drop liquid-phase microextraction cell fishing with gas chromatography-mass spectrometry for screening bioactive components from AmomumvillosumLour, Biomedical Chromatography,April 2015, 29(4): 626-632,  Thomson Reuters JCR期刊分區: Q3.

9. Tie-Xin Tang, Xin-Jun Xu, Dong-Mei Wang, Zhi-Min Zhao*(共同通訊作者)Long-Ping Zhu&De-Po Yang*. A Rapid and Green Limit Test Method for Five Synthetic Colorants in Foods Using Polyamide Thin-layer Chromatography. Food Analytical Methods, FEB 2015, 8(2): 459-466, Thomson Reuters JCR期刊分區: Q2.

10. XueXue, Zhimin Zhao*(共同通訊作者), Qing Li, Dongmei Wang, Xinjun Xu, Longping Zhu, Depo Yang*,  Determination of Flavonoids by Solidificationof Floating Organic Drop Liquid-Phase Microextraction and High-Performance Liquid Chromatography, Analytical Letters, FEB 2016, 49 (15), 2384-2396Thomson Reuters JCR期刊分區: Q4.

11. Xuan-Ming Zhang, De-Po Yang, Zhi-Yong Xie, Qing Li, Long-Ping Zhu&Zhi-Min Zhao* (通訊作者). Two new glycosides isolated from Sapindus mukorossi fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells. Natural ProductResearch,2016, 30 (13), 1459-1463. Thomson Reuters JCR期刊分區: Q3.

12. Hang Li, Zi-ZheCai, Long-Ping Zhu, Xin-Jun Xu, Shao-RuiChen, De-Po Yang &Zhi-Min Zhao* (通訊作者), A new bibenzyl derivative with nuclear factor-kappaB inhibitory activity from Schefflera arboricola (Araliaceae), Natural Product Research, JUN 2015, 29 (12), 1139-1144, Thomson Reuters JCR期刊分區: Q3.

13. Xuan-Ming Zhang, De-Po Yang, Zhi-Yong Xie, Xue Xue, Long-Ping Zhu, Dong-Mei Wang &Zhi-Min Zhao*(通訊作者). A new triterpenoid saponin and an oligosaccharide isolated from the fruits of Sapindusmukorossi. Natural Product Research, 2014, 28(14), 1058-1064,Thomson Reuters JCR期刊分區: Q3

14. Zhimin Zhao(第一作者), Katsuyoshi Matsunami, Hideaki Otsuka*, Nisha Negi, Ashok Kumar, Devendra Singh Negi, A condensed phenylpropanoid glucoside and pregnane saponins from the roots of Hemides musindicus, Journal of Natural Medicines,JAN 2013, 67 (1), 137-142Thomson Reuters JCR期刊分區: Q3.

15. Zhimin Zhao(第一作者),Katsuyoshi Matsunami, Hideaki Otsuka*, Takakazu Shinzato, Yoshio Takeda, Tareciliosides NS: Further cycloartane saponins from the leaves of Tarenna gracilipes, and cytotoxicity of saponins and tritepenes. Journal of Natural Medicines, JUL 2013, 67 (3), 503-511Thomson Reuters JCR期刊分區: Q3.

16. Zhongbin Cheng, Jingjun Zhao, Dong Liu, Peter Proksch, Zhimin Zhao*(共同通訊作者), Wenhan Lin*, Eremophilane-Type Sesquiterpenoids from an Acremoniumsp Fungus Isolated from Deep-Sea Sediments, Journal of Natural Products, APR 2016, 79 (4), 1035-1047.Thomson Reuters JCR期刊分區: Q1.

17. Zhimin Zhao, Katsuyoshi Matsunami, Hideaki Otsuka, Takakazu Shinzato, Yoshio Takeda, Tarecilioside H-M: Further Cycloartane glycosides from leaves of Tarenna gracilipes Chemical & Pharmaceutical Bulletin, JUL 2011, 59 (7), 902-905, Thomson Reuters JCR期刊分區: Q3.

18Zhimin Zhao, Katsuyoshi Matsunami, Hideaki Otsuka, Takakazu Shinzato, Yoshio Takeda, Masatoshi Kawahata, Kentaro Yamaguchi, Schefflerins A-G, New Triterpene Glucosides from the Leaves of Schefflera arboricola, Chemical & Pharmaceutical Bulletin, OCT 2010, 58 (10), 1343-1348,  Thomson Reuters JCR期刊分區: Q3

19. Zhimin Zhao, Katsuyoshi Matsunami, Hideaki Otsuka, Takakazu Shinzato, Yoshio Takeda, Tareciliosides A-G: Cycloartane glycosides from leaves of Tarenna graccilipes (HAY.) OHWI..Chemical & Pharmaceutical Bulletin, AUG 2008, 56 (8), 1153-1158,  Thomson Reuters JCR期刊分區: Q3

20. 趙志敏(第一作者)南豔平,唐青濤,趙宏偉,郭未豔,楊得坡無患子總皂苷抗炎及抑制酪氨酸酶活性研究[J],時珍國醫國藥, 2014, 25(7)1592-1595,核心期刊。

21. 趙志敏(第一作者)南豔平,唐青濤,趙宏偉,郭未豔,楊得坡。無患子總皂苷的體外抑菌及抗氧化活性研究[J],時珍國醫國藥, 2013 , 24(4)799-801,核心期刊。

22.闵歡,趙志敏,郭未豔,楊得坡,成金樂,尖齒臭茉莉的化學成分及其自由基清除活性研究,中草藥,2012,436), 1050-1056.核心期刊。

申請專利:

     1. 楊得坡,熊瑛,趙志敏,何穎,朱龍平,莊勇,郭未豔,楊文哲,王冬梅。一種去除植物精油中塑化劑的方法,專利号ZL 2012 1 0008766.5,專利申請日:20110112日,

  發明專利,授權時間:20140618日,專利權人:中山大學,中山市尤利卡天然藥物有限公司。

    2. 楊得坡,薛雪趙志敏,楊文哲,林麗劉琴,鄭冬,蔡子哲,何國瑞。一種防治皮膚炎症及護膚的外用制劑。專利申請:CN201610328952.5,專利公開(公告)号

   CN105878113A,專利申請日:20160518日,發明專利,專利權人:中山市尤利卡天然藥物有限公司,中山大學。

   3. 楊得坡,蔡子哲 趙志敏,吳勝清,楊文哲,彭詩儀。基于蠅蛆油的生物潤滑基礎油及其制備方法。專利申請号:CN201610088405.4,專利公開(公告)号:CN105754726A

  專利申請日:2016年02月17日,發明專利,專利權人:中山大學,中山市尤利卡天然藥物有限公司,廣州燕穗生物科技有限公司。

獲獎情況

1.2017年作為第三完成者獲得中山大學第八屆校級教學成果二等獎。

2.2013年11月,2013年中山大學醫科中青年教師普通話授課大賽暨青年教師全英授課大賽獲中文組優勝獎。

3.2009.4-2010.3 獲得日本文部省學習獎勵費。

4.2008.4-2009.3 獲得日本熊平财團法人獎學金。

5.2006.4-2008.3 獲得日本文部省學習獎勵費。

 

學術交流

1. Bai Bai , Shao-Xia Ye, De-Po Yang, Long-Ping Zhu, Gui-Hua Tang, Yun-Yun Chen, George Qian Li and Zhi-Min Zhao*,Chloraserrtone A, a Sesquiterpenoid Dimer from Chloranthus serratus CCS12th National Symposium on Natural Organic Chemistry,Kunming, China, Jul. 28-31, 2018, p152.

2. Shi-yi Peng, Hang Li, De-po Yang, Bai Bai, Long-ping Zhu, Qin Liu, Juan Shen, Zhi-min Zhao* (通訊作者), Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum, The International Symposium for Graduate Students on Pharmaceutical Sciences 2016 and the Annual AAPS-SYSU Student Chapter Research Symposium, Guangzhou, China, Sep. 01-04, 2016, p131.

3. Bai Bai, Shiyi Peng, Hang Li, Qin Liu, Juan Shen, Longping Zhu, Zhimin Zhao* (共同通訊作者), Depo. Yang*, Two new iridoids from aerial part of Gelsemium elegans. The International Symposium for Graduate Students on Pharmaceutical Sciences 2016 and the Annual AAPS-SYSU Student Chapter Research Symposium, Guangzhou, China, Sep. 01-04, 2016, p150.

4. Xuan-Ming Zhang, De-Po Yang, Xie-Zhi Yong, Qing Li, Long-Ping Zhu, Zhi-Min Zhao* (通訊作者), Two novel glycosides isolated from Sapindus mukorossi fruits: Effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells, The 5th Pharmacy postgraduates Academic Forum in China. Guangzhou, China, Aug. 26-29, 2014, p56.

5. Xue Xue, Depo Yang, Dongmei Wang, Xinjun Xu, Longping Zhu, Zhimin Zhao* (通訊作者), Solidification of floating organic drop liquid phase microextraction (SFOD-LPME) cell fishing with GC-MS for screening bioactive components from Amomum villosum Lour., The 5th Pharmacy postgraduates Academic Forum in China. Guangzhou, China, Aug. 26-29, 2014, p50 .

6. Hang Li, Jin-Long Chen, Long-Ping Zhu, Xin-Jun Xu, De-Po Yang*, Zhi-Min Zhao* (共同通訊作者), Noditerpenoids from Flickingeria fimbriat (Orchidaceae), CCS 10th national symposium on Natural Organic Chemistry Guangzhou, China, Nov. 21-23, 2014, p154.

7. FutherCycloartaneClycosides from Leaves of TarennagracilipesChinese Medicinal Chemistry Symposium, Guangzhou,China, Nov.17-20,2011
8. Steroidal Saponins from an Ayurvedic Plant-Hemidesmusindicus,The 130th Conference of the Pharmaceutical society of Japan, Okayama Mar. 28, 2010

9. Chemical study on constituents from leaves of ScheffleraarboricolaHayata,The 56th Annual Meeting of Japanese Society of Pharmacognosy, Kyoto  Oct. 4, 2009

   10. Chemical study on constituents from leaves of TarennaGracilipesOhwi (2),The 127th Conference of the Pharmaceutical society of Japan, Toyama  Mar. 29, 2007

    11. Chemical study on constituents from leaves of TarennagracilipesOhwiThe 126th Conference   of  the Pharmaceutical society of Japan, Sendai  Mar. 29, 2006