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簡單介紹

藍文健：太阳集团1088vip教授、博導。美國Oregon State University訪問學者，廣東省高等學校 “千百十人才培養工程”培養對象。在中山大學化學學院海洋天然産物研究所獲得博士學位後留校任教，多年來一直緻力于南海海洋生物共生微生物的藥用活性物質研究。建立了高效的微生物分離與種屬鑒定技術；發展了氨基酸導向培養方法等多種培養策略，激活微生物“沉默基因”，誘導真菌多産、高産結構新穎活性生物堿等代謝産物；開展基于化學結構新穎性和生物活性的代謝産物研究，發現先導化合物；探讨重要代謝産物的生源合成途徑。從南海軟珊瑚、海綿、海星等生物體内分離純化1000多株真菌和細菌，鑒定數百株微生物種屬；開展部分真菌代謝産物研究，從中發現500餘個化合物，近百個化合物具有顯著抗腫瘤、抗病毒、抗菌等藥用活性。近兩年重點探索深海、熱液、冷泉等極端環境微生物活性代謝産物，發現治療惡性腫瘤、病毒性感染等重大疾病的候選藥物。先後主持3項國家自然科學基金、8項廣東省科技計劃和自然科學基金等10餘項科研項目。以第一或通訊作者在Organic Letters，Journal of Natural Products，Bioorganic Chemistry，Frontiers in Microbiology等國際著名期刊發表高水平文章50餘篇；申請專利7件，其中4件獲得授權。目前擔任廣東藥學會第十七屆制藥專委會常務委員，中國菌物學會化學專委會委員。

研究方向

1．海洋微生物（真菌、細菌、放線菌等）活性代謝産物的發現與藥用研究。

2．嶺南中藥的活性成分研究。

課題組長期招聘微生物學、天然藥物化學、藥物化學、生物化學與分子生物學等專業的特聘研究員、特聘副研究員和博士後。

教學情況

本科生：《天然藥物化學》（理論和實驗課）《有機化學實驗》
研究生：《天然産物化學及其研究方法》

論著專利

以通訊作者發表的部分論文：

  1. Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41-1 to Maximize Alkaloid Diversity. Organic Letters, 2017, 19(18), 4888-4891.
  2. Pseudellones A−C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheriaellipsoidea F42−3. Organic Letters, 2015, 17(21), 5156-5159. 
  3. Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus Scedosporium apiospermum F41‑1. Journal of Natural Products. 2020, 83(4), 1082-1091.
  4. L-Tryptophan Induces a Marine-Derived Fusarium sp. to Produce Indole Alkaloids with Activity against the Zika Virus. Journal of Natural Products, 2020, 83(11), 3372-3380.
  5. L‑Phenylalanine Alters the Privileged Secondary Metabolite Production in the Marine-Derived Fungus Trichoderma erinaceum F1‑1. Journal of Natural Products, 2020, 83 (1), 79-87.
  6. β-Carboline Alkaloids from the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-Pulmonary Fibrosis Agent that Inhibits TGF-b/Smad Signaling Pathway. Frontiers in Microbiology, 2022.
  7. Biotransformations of Anthranilic Acid and Phthalimide to Potent Antihyperlipidemic Alkaloids by the Marine-Derived Fungus Scedosporium apiospermum F41-1. Bioorganic Chemistry, 2021, 116, 105375: 1-8.
  8. Phomaligols F-I, Polyoxygenated Cyclohexenone Derivatives from Marine-Derived Fungus Aspergillus flavus BB1. Bioorganic Chemistry, 2021, 115, 105269: 1-8.
  9. Pseudapenes A-C, Sesquiterpenoids from the Marine-Derived Fungus Pseudallescheria apiosperma F52-1. Tetrahedron Letters, 2019, 60(34), 150953: 1-4.
  10. Characterization, Antioxidant and Antitumor Activities of Oligosaccharides Isolated from Evodia lepta (Spreng) Merr. by Different Extraction Methods. Antioxidants 2021, 10(11), 1842.
  11. Secondary Metabolites with Chemical Diversity from the Marine-Derived Fungus Pseudallescheria boydii F19-​1 and Their Cytotoxic Activity. RSC Advances, 2016, 6(80), 76206-76213.
  12. Discovery of Aromadendrane Anologues from the Marine-Derived Fungus Scedosporium dehoogii F41-4 by NMR-Guided Isolation. RSC Advances, 2016, 6(80), 94763-94770.
  13. NMR Screening Approach for Discovery of New 6-Methylpyridinone Derivatives from the Marine-Derived Fungus Leptosphaerulina sp. Arabian Journal of Chemistry, 2017, 10(2), 288-294.
  14. Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. International Journal of Molecular Sciences, 2015, 16(8), 19401-19418.
  15. Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy. Marine Drugs, 2019, 17(2), 77: 1-9.

其餘文章省略。