徐曉宇,博士,太阳集团1088vip副教授,博導。2021年博士提前畢業于太阳集团1088vip,獲藥劑學博士學位。2021-2024年期間在中國科學院深圳先進技術研究院從事博士後研究工作。2024年8月入職太阳集团1088vip。先後主持國家自然科學基金青年項目、深圳市基礎研究面上項目、廣東省區域聯合基金青年項目、中國博士後科學基金面上一等資助、先進院優秀青年創新基金共5項課題,并參與廣東省納米醫藥重點實驗室、國家重點研發計劃子課題等科研項目。迄今相關研究成果共發表SCI論文20餘篇,其中以第一作者(含共同)在Advanced Functional Materials、ACS Nano、Nano Today、Biomaterials、Chemical Engineering Journal、Theranostics、Carbohydrate Polymers、ACS Applied Materials & Interfaces、European Journal of Medicinal Chemistry等國際權威學術期刊發表論文10餘篇。申請國家發明專利10餘項。擔任ACS Applied Materials & Interfaces、Journal of Controlled Release、International Journal of Biological Macromolecules、International Journal of Pharmaceutics等藥劑學領域期刊審稿人。現擔任Exploration雜志青年編委,Pharmaceutics雜志特刊主題“ROS-Mediated Nano Drug Delivery for Antitumor Therapy”客座編輯(歡迎投稿,截稿日期2025.02.28)。

 

教育與工作經曆

2010.09---2014.07, 太阳集团1088vip,藥學,理學學士

2014.09---2017.07, 太阳集团1088vip,藥劑學,理學碩士

2018.09---2021.07, 太阳集团1088vip,藥劑學,理學博士

2021.07---2024.07, 中國科學院深圳先進技術研究院(SIAT),博士後

2024.08------至今, 太阳集团1088vip,藥劑學教研室,副教授,博士生導師

 

研究方向

智能藥物遞送及控釋系統,工程化免疫細胞(CAR-T,NK等)療法,臨床疾病多模式診療一體化    

方向描述:以臨床腫瘤等重大疾病的預防、診斷和治療所面臨的科學難題及迫切需求為導向,融合藥學,臨床醫學,細胞/分子生物學,免疫學,生物醫學工程等交叉學科,設計及開發基于生物活性功能元件的智能藥物制劑及多模式診療一體化系統,以期實現臨床重大疾病的精準可控,安全高效的診斷和治療模式。

 

科研項目

國家自然科學基金青年項目,82204302,2023.01-2025.12,30萬,主持

深圳市基礎研究面上項目,JCYJ20220531095815034,2022.10-2025.10,30萬,主持

廣東省區域聯合基金青年項目,2021A1515110884,2021.10-2024.09,10萬,主持

中國博士後科學基金第71批面上一等資助,2022M710160,2022.08-2024.07,12萬,主持

深圳先進技術研究院優秀青年創新基金,E2G0441001,2022.03-2023.12,10萬,主持

 

代表性論文

1.  X. Xu, M. Chen, S. Jiang, Z. Pan, C. Zhao, Endoplasmic Reticulum-Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono-Immunotherapy, Advanced Functional Materials (2024) 2314780. (中科院1區,TopIF=19.0)

2.  X. Xu, J. Zheng, N. Liang, X. Zhang, S. Shabiti, Z. Wang, S. Yu, Z. Pan, W. Li, L. Cai, Bioorthogonal/Ultrasound Activated Oncolytic Pyroptosis Amplifies In Situ Tumor Vaccination for Boosting Antitumor Immunity, ACS Nano 18 (2024) 9413-9430. (中科院1區,TopIF=17.1)

3.  X. Xu, S. Shabiti, X. Zhang, J. Zheng, N. Liang, Z. Wang, S. Yu, Y. Wang, S. Jiang, Z. Pan, W. Li, L. Cai, Membrane-Anchoring Clickable Iridium(III) Nanosonosensitizer In Situ Evokes PANoptosis for Augmented Tumor Sono-Immunotherapy, Nano Today (2024) 102270. (中科院1區,TopIF=17.4)

4.  X. Xu, Z. Zeng, X. Ding, T. Shan, Q. Liu, M. Chen, M. Xia, Y. He, Z. Huang, Y. Huang, C. Zhao, Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy, Biomaterials 277 (2021) 121128. (中科院1區,TopIF=14.0)

5.  X. Xu#, Z. Zeng#, J. Chen, B. Huang, Z. Guan, Y. Huang, Z. Huang, C. Zhao, Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction, Chemical Engineering Journal 390 (2020) 124628. (中科院1區,TopIF=15.1)

6.  X. Xu#, B. Huang#, Z. Zeng, J. Chen, Z. Huang, Z. Guan, M. Chen, Y. Huang, C. Zhao, Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy, Theranostics 10 (2020) 10513-10530. (中科院1區,TopIF=12.4)

7.  X. Xu, Z. Zeng, Z. Huang, Y. Sun, Y. Huang, J. Chen, J. Ye, H. Yang, C. Yang, C. Zhao, Near-infrared light-triggered degradable hyaluronic acid hydrogel for on-demand drug release and combined chemo-photodynamic therapy, Carbohydrate Polymers 229 (2020) 115394. (中科院1區,TopIF=11.2)

8.  X. Xu, Z. Huang, Z. Huang, X. Zhang, S. He, X. Sun, Y. Shen, M. Yan, C. Zhao, Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemophotothermal Synergistic Cancer Therapy, ACS Applied Materials & Interfaces 9 (2017) 20361-20375. (中科院2區,TopIF=9.5)

9.  R. Guan#, X. Xu#, M. Chen#, H. Hu, H. Ge, S. Wen, S. Zhou, R. Pi, Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors, European Journal of Medicinal Chemistry 70 (2013) 613-622. (中科院2區,TopIF=6.7)

10.  Z. Zeng#, Y. Luo#, X. Xu, T. Shan, M. Chen, Z. Huang, Y. Huang, C. Zhao, A mitochondria-targeting ROS-activated nanoprodrug for self-augmented antitumor oxidation therapy, Journal of Controlled Release 359 (2023) 415-427. (中科院1區,TopIF=10.8)

11.  X. Sun#, D. Liu#, X. Xu, Y. Shen, Y. Huang, Z. Zeng, M. Xia, C. Zhao, NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor, Asian Journal of Pharmaceutical Sciences 15(6) (2020) 713-727. (中科院1區,IF=10.2)

12.  Z. Lan, X. Xu, W. Xu, J. Li, Z. Liang, X. Zhang, M. Lei, C. Zhao, Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent, Drug Design, Development and Therapy 9 (2015) 3377-91. (中科院2區,IF=4.8)

13.  蔡林濤,徐曉宇,李文軍,潘正銀,鄭金玲,梁娜,張旭,沙依拜,王子茜。一種生物正交激活的聲敏劑、納米顆粒及制備方法與應用,中國,CN202311833768.2