吳自俊，博士生導師。2019年博士畢業于清華大學太阳集团1088vip，随後加入加拿大渥太華大學化學與分子生物科學系開展博士後研究。2024年2月加入太阳集团1088vip（廣州）。吳自俊博士研究方向為自由基化學與化學生物學，研究興趣包括解析生物大分子的自由基過氧化反應機理以及它們對機體的調控機制、研究抗氧化防禦策略、開發高效的分子構建工具用于獲取具有抗氧化防禦功能的化合物。主要科學貢獻包括：揭示了FSP1/維生素K、過硫化氫、膽固醇等内源性防禦體系調控鐵死亡及其作用機制；開展了有機硼、吩噁嗪和酚噻嗪類等小分子抗氧化劑的研究，并通過結構構效關系研究揭示了它們在調控鐵死亡上的應用；提出了自由基二硫化合成策略，并通過該策略制備了一系列具有潛在抑制鐵死亡活性的二硫化物。目前已在Nature、 Nature Reviews Chemistry、Journal of the American Chemical Society、Angewandte Chemie International Edition、Current Opinion in Chemical Biology、ACS Catalysis、ACS Chemical Biology等期刊發表論文共22篇， 1篇研究文章入選高被引用論文，4篇研究文章先後被Nature、 Nature Chemical Biology、 Molecular Cell、 Cell Chemical Biology、 Synform、 Organic Chemistry Portal等國際頂尖專業期刊和平台以“News and views”、“Spotlight”等形式多次評論、報道。

Google Scholar Profile: https://scholar.google.com/citations?user=8cmuJXgAAAAJ&hl=en&oi=ao 

課題組現誠聘博士後（藥物化學研究方向）！熱情歡迎對交叉學科研究感興趣的同學（化學、藥學均可）就加入課題組學習和交流與我們聯系！

代表性研究成果：

1. Zijun Wu, Robynne Vlaming, Michael Donohoe, Derek A. Pratt*, Interrupted homolytic substitution enables organoboron compounds to inhibit radical chain reactions rather than initiate them, Journal of the American Chemical Society 2024, 146, 1153−1166.
2. Zijun Wu, Derek A. Pratt*, Radical approaches to C-S bonds. Nature Reviews Chemistry 2023, 7, 573−589.
3. Zijun Wu, Vinayak S. Khodade, Jean-Philippe Chauvin, Deborah Rodriguez, John P. Toscano, Derek A. Pratt*, Hydropersulfides inhibit lipid peroxidation and protect cells from ferroptosis. Journal of the American Chemical Society 2022, 144, 15825−15837.
4. Eikan Mishima*, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A. Pratt, Marcus Conrad*, A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature 2022, 608,778−783.
5. Zijun Wu, Derek A. Pratt*, A divergent strategy for site-selective radical disulfuration of carboxylic acids with trisulfide 1,1-dioxides. Angewandte Chemie International Edition 2021, 60, 15598−15605.
6. Zijun Wu, Derek A. Pratt*, Radical substitution provides a unique route to disulfides. Journal of the American Chemical Society 2020, 142, 10284−10290.
7. Zijun Wu‡, Uladzimir Barayeu‡, Danny Schilling, Tobias P. Dick*, Derek Pratt*, Emergence of (hydro)persulfides as suppressors of lipid peroxidation and ferroptotic cell death. Current Opinion in Chemical Biology, 2023, 76, 102353−102360. (‡equal contribution)