姜伊鳴博士，太阳集团1088vip副教授，中山大學逸仙新銳學者。研究方向為藥物代謝對肝髒生理和病理的調控作用的相關研究。2008至2018年在太阳集团1088vip進行本科、碩士及博士學習，2017年受國際交流項目資助赴美國國立衛生研究院訪問學習。先後主持國家自然科學基金面上項目、國家自然科學基金青年項目、廣東省自然科學基金面上項目、廣州市科技計劃等項目6項，參與國家重點研發計劃等國家級項目9項。研究成果共發表SCI論文30餘篇，其中一作/通訊發表在Adv Sci、Hepatology、Br J Pharmacol、Toxicol Sci、Acta Pharmacol Sin等知名學術刊物上。申請國家發明專利9項，已獲授權4項；2018年獲得中國藥理學會藥物代謝-劉昌孝人才獎。

2024年招生計劃：招藥理學碩1名，藥物評價專碩1名

教育與工作經曆

2008.09-2012.06，太阳集团1088vip，藥學專業，獲學士學位

2012.09-2015.06，太阳集团1088vip，藥學碩士專業，獲碩士學位

2015.09-2018.06，太阳集团1088vip，藥理學專業，獲博士學位

2017.09-2017.12, 美國國立衛生研究院（NIH），訪問學習

2018.08-2021.08，太阳集团1088vip，特聘副研究員

2021.09-至今，太阳集团1088vip，副教授

 

學術/社會任職

中國藥理學會藥物代謝青年委員會委員

廣東省藥理學會藥物代謝委員會委員

廣東省藥理學會臨床藥理委員會委員

廣東省藥理學會藥理毒理委員會委員

 

科研項目

  1. 國家自然科學基金-面上項目，82173881，負責人；

  2. 國家自然科學基金-青年項目，82003840，負責人；

  3. 廣州市科技基礎與應用基礎研究項目，2024A04J9901，負責人

  4. 中央高校基本科研業務項目，22qntd4502，負責人

  5. 廣東省自然科學基金-面上項目，2019A1515010247，負責人；

  6. 廣州市科技基礎與應用基礎研究項目，202102020717，負責人。

 

代表性論文

  1. Tingting Zhao#, Guoping Zhong#, Ying Wang, Renjie Cao, Shaofei Song, Yuan Li, Guohui Wan, Haiyan Sun, Min Huang*, Huichang Bi*, Yiming Jiang (姜伊鳴)*. Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin-induced Liver Injury. Adv Sci. 2024, e2308771. DOI: 10.1002/advs.202308771.

  2. Shaofei Song#, Hong Peng#, Yuan Li, Tingting Zhao, Renjie Cao, Lei Zheng, Min Huang, Yiming Jiang (姜伊鳴)*. Oleanolic acid promotes liver regeneration after partial hepatectomy via regulating pregnane X receptor signaling pathway in mice. Chemico-Biological Interactions. 2024. https://doi.org/10.1016/j.cbi.2024.110970

  3. Yiming Jiang# (姜伊鳴), Yanying Zhou#, Shaofei Song, Shicheng Fan, Yue Gao, Yuan Li, Min Huang*, Huichang Bi*. St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation. Toxicol Sci. 2022 Oct 27;190(1):54-63.

  4. Yiming Jiang (姜伊鳴), Xinpeng Yao, Shicheng Fan, Yue Gao, HuizhenZhang, Min Huang*, Huichang Bi*. Lipidomic profiling reveals triacylglycerol accumulation in the liver during pregnane X receptor activation-induced hepatomegaly. J Pharm Biomed Anal. 2021 Feb 20:195:113851.

  5. Yiming Jiang# (姜伊鳴), MinghuaJin#, Jingkao Chen#, Jinwu Yan, PeiqingLiu, Meicun Yao, Weibin Cai, Rongbiao Pi*.Discovery of a novel niacin-lipoic aciddimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. Eur J Pharmacol. 2020 Feb 5;868:172871.

  6. Yiming Jiang (姜伊鳴), Dechun Feng, Xiaochao Ma, Shicheng Fan, Yue Gao, Kaili Fu, Ying Wang, Jiahong Sun, Xinpeng Yao, Conghui Liu, Huizhen Zhang,Leqian Xu, Aiming Liu, Frank J. Gonzalez, Yingzi Yang, Bin Gao, Min Huang, Huichang Bi*. Pregnane X Receptor Regulates Liver Size and Liver Cell Fate via Yes-associated Protein Activation. Hepatology. 2019 Jan;69(1):343-358.

  7. Hang Zeng#, Yiming Jiang# (姜伊鳴，共同一作),Pan Chen, Xiaomei Fan, Dongshun Li, Aiming Liu, Xiaochao Ma, Wen Xie, Peiqing Liu, Frank J Gonzalez, Min Huang and Huichang Bi*, Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br J Pharmacol. 2017 Apr;174(8):672-688.

  8. Huizhen Zhang#, Yiming Jiang# (姜伊鳴，共同一作), Jingjing Wu, Chuanqi Zheng, Xiaorong Ran, Dongshun Li, Min Huang, Huichang Bi*.Metabolic mapping of Schisandra sphenanthera extract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high-resolution mass spectrometry. J Sep Sci. 2017 Jan;40(2):574-586.

  9. Yiming Jiang# (姜伊鳴), Ying Wang#, Huasen Tan, Tao Yu, Xiaomei Fan, Pan Chen, Hang Zeng, Min Huang*, Huichang Bi*. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway. Acta Pharmacol Sin. 2016 Mar;37(3):382-9.

  10. Yiming Jiang# (姜伊鳴), Xiaomei Fan#, Ying Wang , Huasen Tan, Pan Chen, Hang Zeng , Min Huang*,Huichang Bi*. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chem Biol Interact. 2015 25;231:83-9.

  11. Ying Wang#, Yiming Jiang# (姜伊鳴，共同一作), Xiaomei Fan, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Min Huang, Huichang Bi*. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Toxicol Lett. 2015 16;236(2):82-9.

  12. Yiming Jiang# (姜伊鳴), Xiaomei Fan#, Ying Wang, Pan Chen, Hang Zeng,Huasen Tan, Frank J. Gonzalez, Min Huang* and Huichang Bi*. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan;143(1):107-15.

Xiaomei Fan#, Yiming Jiang# (姜伊鳴，共同一作), Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen,Aijuan Qu, Frank J. Gonzalez, Min Huang, and Huichang Bi*. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos. 2014 Dec;42(12):1982-90.