Albert S. C. Chan, Ph. D.

Member of Chinese Academy of Sciences

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong.  

■ Education

Ph. D. (Chemistry), University of Chicago, 1979. 

M. Sc. (Chemistry), University of Chicago, 1976. 

A. B.  (Chemistry), International Christian University, Tokyo, Japan, 1975.

■ Employment

Chair Professor and Head of Department

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong (1994 - current).

■ Reader 

Department of Chemistry, Hong Kong University of Science and Technology (1993).

■ Visiting   Professor 

Department of Chemistry, National Taiwan University; 1992 - 1993.

Department of Chemistry, National Chung Hsing University, 1993-94. 

Monsanto Fellow (1987-1992); Senior Research Specialist (1983-1987); 

Research   Specialist (1982-1983); Senior Research Chemist (1979-1982);

All at Monsanto Corporate Research Center, U. S. A. 

■ Public Services

Regional Editor (for Asia and Australasia), 

Inorganic Chemistry Communications, (published by Elsevier Publishers).

Editor-in-Chief, Chemistry in Hong Kong.

Consulting Editor, Accounts of Chemical Research.

Editorial Advisory Board Advanced Synthesis and Catalysis

■ Research   Interest

(1) Asymmetric Syntheses and Their Industrial Applications.

(2) Development of Pharmaceutical Products and Related Processes.

(3) Pharmaceutical and Nutritional Products based on Chinese Medicines.

(4) New Process Sciences and Their Industrial Applications.

■ Selected Recent Publications (out of about 200 SCI publications)

1. Fan, Q. H.; Li, Y. M.; Chan, A. S. C.  “Recoverable Catalysts for Asymmetric Synthesis”, Chemical Review, 2002, in press.

2. Chan, A. S. C.; Hu, W. H.; Pai, C. C.; Lau, C. P.; Jiang, Y. Z.; Mi, A. Q.; Yan, M.; Sun, J.; Lou, R. L.; Deng, J. G. Novel spiro phosphinite ligands and their application in homogeneous catalytic hydrogenation reactions Journal of the American Chemical Society 1997, 119(40), 9570-9571. 

3. Chan, A. S. C.;  Zhang, F. Y.; Yip, C. W.  Novel Asymmetric Alkylation of Aromatic Aldehydes with Triethylaluminum Catalyzed by Titanium (1,1 -bi-2-naphthol) and Titanium 5,5 , 6,6 , 7,7 , 8,8 -octahydro-1,1 -bi-2-naphthol) Complexes Journal of the American Chemical Society  1997, 119(17), 4080-4081.

4. Zhang, F. Y.; Pai, C. C.; Chan, A. S. C. Asymmetric synthesis of chiral amine derivatives through enantioselective hydrogenation with a highly effective rhodium catalyst containing a chiral bisaminophosphine ligand Journal of the American Chemical Society 1998, 120(23), 5808-5809. 

5. Fan, Q. H.; Ren, C. Y.; Yeung, C. H.; Hu, W. H.; Chan, A. S. C. Highly effective soluble polymer-supported catalysts for asymmetric hydrogenation Journal of the American Chemical Society 1999, 121(32), 7407-7408. 

6. Pai, C. C.; Lin, C. W.; Lin, C. C.; Chen, C. C.; Chan A. S. C. Highly effective chiral dipyridylphosphine ligands: Synthesis, structural determination, and applications in the Ru-catalyzed asymmetric hydrogenation reactions Journal of the American Chemical Society 2000, 122(46), 11513-11514 

7. Hong, M. C.; Zhao, Y. J.; Su, W. P.; Cao, R.; Fujita, M.; Zhou, Z. Y.; Chan, A. S. C. A nanometer-sized metallosupramolecular cube with O-H symmetry Journal of the American Chemical Society 2000, 122(19), 4819-4820. 

8. Li, T.; Liu, D.;Chen, J.; Lee, A. H. F.; Chan, A. S. C. Construction of oligodeoxyribonucleotides on the new structural basis of I-motif, Journal of the American Chemical Society 2001, 123, 12901-12902.

9. Li, X.; Lu, G.; Kwok, W. H.; Chan, A. S. C. “Highly Enantioselective Alkynylzinc Addition to Aromatic Aldehydes Catalyzed by Self-Assembled Titanium Catalysts”, Journal of the American Chemical Society 2002, in press.

10. Hong, M. C.; Zhao, Y. J.; Su, W. P.; Cao, R.; Fujita, M.; Zhou, Z. Y.; Chan, A. S. C.  A Silver(I) coordination polymer chain containing nanosized tubes with anionic and solvent molecule guests Angewandte Chemie: International Edition 2000, 39(14), 2468-+. 

■ U. S. Patents.

1. Albert S. C. Chan; Y. Z. Jiang; A. Q. Mi; M. Yan; W. H. Hu Chiral phosphinites U. S. Patent 5,756,799, May 26, 1998 

2. Albert S. C. Chan; F. Y. Zhang Chiral aminophosphines U. S. Patent 5,919,981, July 6, 1999 

3. Albert S. C. Chan; F. Y. Zhang Chiral aminophosphines U. S. Patent 5,952,527, September 14, 1999 

4. Albert S. C. Chan; Q. H. Fan Soluble polyester-supported chiral phosphines U. S. Patent 5,990,318, November 23, 1999 

5. Albert S. C. Chan; C. C. Pai Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids U. S. Patent 5,886,182, March 23, 1999 

6. Albert S. C. Chan Method for preparing ?-arylpropionic acids U. S. Patent 5,233,084, August 3, 1993 

7. Albert S. C. Chan Asymmetric catalytic hydrogenation of ?-arylpropenoic acids U. S. Patent 5,202,474, April 13, 1993 

8. Albert S. C. Chan; Scott A. Laneman Ruthenium-BINAP asymmetric hydrogenation catalyst U. S. Patent 5,202,473, April 13, 1993 

9. Albert S. C. Chan; Scott A. Laneman Ruthenium-BINAP asymmetric hydrogenation catalyst U. S. Patent 5,198,561, March 30, 1993 

10. Albert S. C. Chan; Scott A. Laneman Ruthenium(II)-BINAP diketonate complexes U. S. Patent 5,144,050, September 1, 1992 

11. Albert S. C. Chan Asymmetric catalytic hydrogenation of ?-arylpropenic acids U. S. Patent 4,994,607, February 19, 1991 

12. Albert S. C. Chan Fluoride stability in dicalcium phosphate dihydrate composition U. S. Patent 5,037,636, August 6, 1991 

13. Albert S. Chan; John R. Wiedemann; Samuel L. Hull Zinc tripolyphosphate compounds as anticalculus and antiplaque agents U. S. Patent 5,032,389, July 16, 1991 

14. Albert S. C. Chan Process for preparing sodium phenylpyruvate from calcium phenylpyruvate U. S. Patent 4,912,255, March 27, 1990 

15. Albert S. C. Chan; James P. Coleman; Grace M. Wagner Asymmetric hydrogenolysis of epoxides U. S. Patent 4,870,208, September 26, 1989 

16. Albert S. C. Chan Pyrophosphate coating process for calcium carbonate dental abrasives U. S. Patent 4,678,662, July 7, 1987 

17. Albert S. C. Chan; Donald E. Morris Production of adipic acid from 1,4-disubstituted-2-butene U. S. Patent, 4,633,015, December 30, 1986 

18. Albert S. C. Chan; Donald E. Morris Production of hex-3-enedioate esters from 1,4 dialkoxy butenes U. S. Patent 4,611,082, September 9, 1986 

19. Albert S. C. Chan Hydroformylation process to prepare glycolaldehydes U. S. Patent 4,477,685, October 16, 1984 

20. Carroll W. Eamon; Albert S. C. Chan Hydroformylation of formaldehyde with rhodium catalysts U. S. Patent 4,405,814, September 20, 1983

■ Books

(1) Lin, G. Q.; Li, Y, M.; Chan, A. S. C., “Principles and Applications of Asymmetric Synthesis”, John Wiley & Sons, New York, 2001，pp 515.

(2) 林國強，陳耀全，李月明，陳新滋著， 《手性合成? 不對稱反應及其應用》, (373頁)，2000，科學出版社，北京。

(3) 錢延龍，陳新滋主編，《金屬有機化學與催化》，(903頁)，1997，化學工業出版社，北京。該書于1999年獲化工部1996-1997年度部級化工優秀圖書二 等獎。

(4) 王佛松，王夔，陳新滋，彭旭明等主編，《展望21世紀的化學》，258頁，2000，化學工業出版社。