《生物化學與基礎分子生物學實驗》

《生物化學》

《藥學英語》

《科研基礎訓練》

《現代藥物發現中的關鍵技術》

廣東省藥學會藥物化學專業委員會副秘書長

先後主持包括國家自然科學基金優秀青年基金、面上項目及其它省部級項目，并作為主要參加人參與了NSFC-廣東省聯合重點項目、國家自然科學基金重大研究計劃、國家自然科學基金重點項目、科技部國際（政府間）合作項目等的研究工作。入選廣東省特支計劃百千萬工程青年拔尖人才、廣東省優秀青年教師培育計劃、廣州市珠江科技新星等人才項目。近5年共發表高水平論文超過80篇，總他引次數超過2600次。其中第一作者及通訊作者文章二十餘篇，包括Nucleic Acids Research、Cell Chemical Biology等，并有9篇發表在藥物化學頂尖雜志Journal of Medicinal Chemistry。

1. Peng W, Sun ZY, Zhang Q, Cheng SQ, Wang SK, Wang XN, Kuang GT, Su XX, Tan JH, Huang ZS, Ou TM*. Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-quadruplex.  J. Med. Chem. 2018 Aug 9;61(15):6629-6646.

2. Wang SK, Wu Y, Wang XQ, Kuang GT, Zhang Q, Lin SL, Liu HY, Tan JH, Huang ZS, Ou TM*. Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents. J. Med. Chem. 2017 Jul 13;60(13):5306-5319.

3. Zeng DY, Kuang GT, Wang SK, Peng W, Lin SL, Zhang Q, Su XX, Hu MH, Wang H, Tan JH, Huang ZS, Gu LQ, Ou TM*. Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry. J Med Chem. 2017 Jul 13;60(13):5407-5423.

4. Shan C, Yan JW, Wang YQ, Che T, Huang ZL, Chen AC, Yao PF, Tan JH, Li D, Ou TM*, Gu LQ, Huang ZS*. Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex. J Med Chem. 2017 Feb 23;60(4):1292-1308.

5. Liu HY, Zhao Q, Zhang TP, Wu Y, Xiong YX, Wang SK, Ge YL, He JH, Lv P, Ou TM^*, Tan JH, Li D, Gu LQ, Ren J, Zhao Y, Huang ZS^*. Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres. Cell Chem Biol. 2016 Sep 27, 23: 1261-1270.

6. Shan C, Lin J, Hou JQ, Liu HY, Chen SB, Chen AC, Ou TM^*, Tan JH, Li D, Gu LQ, Huang ZS^*. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule..Nucleic Acids Res. 2015 Aug 18; 43(14):6677-91.

7. Wu Y, Zan LP, Wang XD, Lu YJ, Ou TM^*, Lin J, Huang ZS, Gu LQ. Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives. Biochim Biophys Acta. 2014 Sep; 1840(9):2970-7.

8. Wang SK, Wu Y, Ou TM^*. RNA G-Quadruplex: The New Potential Targets for Therapy. Curr Top Med Chem. 2015; 15(19):1947-56.

9. Lin J, Hou JQ, Xiang HD, Yan YY, Gu YC, Tan JH, Li D, Gu LQ, Ou TM^*, Huang ZS^*. Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation. Biochem Biophys Res Commun. 2013 Apr 19; 433(4):368-73.

10. Ou TM, Lin J, Lu YJ, Hou JQ, Tan JH, Chen SH, Li Z, Li YP, Li D, Gu LQ*, Huang ZS*. Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex. J. Med. Chem., 2011 Aug, 54:5671-5679.

11. Wang XD, Ou TM, Lu YJ, Li Z, Xu Z, Xi C, Tan JH, Huang SL, An LK, Li D, Gu LQ, Huang ZS. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. J Med Chem. 2010 Jun 10; 53(11):4390-8. (The first two authors contributed equally to the paper.) 

12. Ou TM, Lu YJ, Zhang C, Huang ZS, Wang XD, Tan JH, Chen Y, Ma DL, Wong KY, Tang JC, Chan AS, Gu LQ. 74. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. J Med Chem. 2007 Apr 5; 50(7):1465-74.

13. Ou TM, Lu YJ, Tan JH, Huang ZS, Wong KY, Gu LQ. G-quadruplexes: targets in anticancer drug design. ChemMedChem. 2008 May; 3(5):690-713.

14. Lu YJ, Ou TM, Tan JH, Hou JQ, Shao WY, Peng D, Sun N, Wang XD, Wu WB, Bu XZ, Huang ZS, Ma DL, Wong KY, Gu LQ. 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation. J Med Chem. 2008 Oct 23; 51(20):6381-92. (The first two authors contributed equally to the paper.)

15. Tan JH, Ou TM, Hou JQ, Lu YJ, Huang SL, Luo HB, Wu JY, Huang ZS, Wong KY, Gu LQ. Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA. J Med Chem. 2009 May 14; 52(9):2825-35. (The first two authors contributed equally to the paper.) 

16. Zhou JL, Lu YJ, Ou TM, Zhou JM, Huang ZS, Zhu XF, Du CJ, Bu XZ, Ma L, Gu LQ, Li YM, Chan AS. Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. J Med Chem. 2005 Nov 17; 48(23):7315-21.

歐田苗教授所在研究團隊的研究項目《基于天然産物結構改造的靶向性藥物先導化合物的基礎性研究》于2010年獲廣東省科學技術獎一等獎和高等學校優秀成果獎-自然科學獎二等獎。

歐田苗教授所在教學團隊的教學研究項目《教研融合—藥學、化學相關專業本科生物化學立體化課程教學體系的創建與實踐》于2017年獲廣東省教學成果獎一等獎。