簡單介紹

路靜,女,博士,太阳集团1088vip副教授,逸仙學者崗位,廣東省傑出青年基金獲得者。20176月獲中山大學藥理學博士學位并留校工作,曆任特聘副研究員、副教授。兼任中國藥理學會教學與科普專業委員會青年委員會副主任委員、中國藥理學會心血管藥理專業委員會青年委員會秘書長、廣東省藥理學會心血管藥理專業委員會常務委員、廣東省藥理學會藥物篩選與評價專業委員會常務委員等。目前主要從事心血管藥理學研究,尋找心肌保護的新靶标、對靶标進行識别和示蹤、并以發現的關鍵靶标篩選先導化合物。

作為項目負責人主持國家自然科學基金面上/青年項目、廣東省自然科學基金傑出青年/面上項目等11項。迄今共發表學術論文70餘篇,其中以第一作者或通訊作者發表學術論文40餘篇,包括Cell Death Differ.Acta Pharm. Sin. BChem. Eng. J.Biosens. Bioelectron.J. Controlled ReleaseJ. Mater. Chem. A 等學術期刊,期刊封面/熱點論文4篇,影響因子大于10分的論文20篇。擔任Nat. Protoc.Acta Pharm. Sin. BBiosens. Bioelectron.Cell Death Dis.J. Adv. Res.等學術期刊審稿人。榮獲2019年度高等學校科學研究優秀成果獎科學技術進步獎二等獎(第八完成人)、廣東省藥理學會2017學術大會青年優秀論文一等獎等。

ORCID-Jing Lu: https://orcid.org/0000-0001-5766-2775

研究方向

1. 心血管治療新靶标的發現和确認

2. 心血管創新藥物研發

3. 核酸适配體識别心衰新靶标

教育經曆

2014-92017-6,太阳集团1088vip,藥理學,理學博士,導師:劉培慶教授

2011-92014-6,太阳集团1088vip,藥理學,理學碩士,導師:劉培慶教授

2007-92011-7,山東第一醫科大學太阳集团1088vip,中藥學,理學學士

工作經曆

2020-7至現在,太阳集团1088vip,藥理學,副教授,碩士生/博士生導師

2017-72020-7,太阳集团1088vip,藥理學,特聘副研究員

學術任職

1. 中國藥理學會心血管藥理專業委員會青年委員會,秘書長

2. 中國藥理學會教學與科普專業委員會青年委員會,副主任委員

3. 廣東省藥理學會心血管藥理專業委員會,常務委員

4. 廣東省藥理學會藥物篩選與評價專業委員會,常務委員

5. 廣東省藥理學會内分泌代謝病藥理專業委員會,常務委員

榮譽獲獎

1. 廣東省藥理學會科技成果獎(9/9),一等獎,2021

2. 中華醫學會醫學科學技術獎(8/8),三等獎,2020

3. 教育部高等學校科學研究優秀成果獎科學技術進步獎(8/11),二等獎,2019

4. 中國藥理學會第十一屆海峽兩岸心血管科學研讨會青年優秀論文,二等獎,2017

5. 廣東省藥理學會第八屆會員代表大會暨2017學術大會青年優秀論文,一等獎,2017

科研項目

1. 國家自然科學基金面上項目,824739142025-12028-12,在研,主持

2. 國家自然科學基金面上項目,821738082022-12025-12,在研,主持

3. 廣東省自然科學基金傑出青年項目,2021B15150201002021-12024-12,在研,主持

4. 廣州市基礎與應用基礎研究項目,2024A04J100132024-42026-3,在研,主持

5. 廣州醫科大學開放課題重點項目,202201-2022022-22025-1,在研,主持

6. 廣州市基礎與應用基礎研究項目,2021020201732021-42023-3,結題,主持

7. 廣東省自然科學基金面上項目,2019A15150102732019-102022-09,結題,主持

8. 國家自然科學基金青年項目,818035212019-12021-12,結題,主持

9. 中山大學青年教師培育項目,19ykpy1312019-12021-12,結題,主持

10. 廣東省中醫藥局面上項目,201910602019-12021-1,結題,主持

11. 廣東省醫學科研基金項目,A20180782018-72020-6,結題,主持

科研論文 (*通訊作者)

2024

1. Wanqing Zou, Luyong Zhang*, Jing Lu*, Duanping Sun*, Recent development of metalorganic frameworks in wound healing: Current status and applications. Chemical Engineering Journal, 2024, 480: 148220. (IF: 13.3)

2. Zhuoliang Hu, Zelin Yang, Mengjie Chen, Wen Chen, Wenjuan Ma*, Jing Lu*, Duanping Sun*, Double hook-type aptamer-based colorimetric and electrochemical biosensor enables rapid and robust analysis of EpCAM expression, Biosensors & Bioelectronics, 2024, 116717. (IF: 10.7)

3. Wanqing Zou, Jing Lu*, Luyong Zhang*, Duanping Sun*, Tetrahedral framework nucleic acids for improving wound healing, Journal of Nanobiotechnology, 2024, 22: 113 (IF: 10.6)

4. Xiuhua Wang, Wei Wan, Jiguo Zhang, Jing Lu*, Peiqing Liu*, Efficient pulmonary fibrosis therapy via regulating macrophage polarization using respirable cryptotanshinone-loaded liposomal microparticles. Journal of Controlled Release, 2024, 366: 1-17. (IF: 10.5)

5. Zeyu Li, Ou Hu, Suowen Xu, Chenjia Lin, Wenjing Yu, Dinghu Ma, Jing Lu*, Peiqing Liu*, The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy, International Journal of Biological Sciences, 2024, 20(3): 831-847.

6. Sheng Zhong, Fayin Mo, Linxi Chen, Weiwei Qin, Luyong Zhang*, Jing Lu*, Duanping Sun*; AgAu-modified quasi-MIL-53 hybrid nanozymes with triple enzyme-like activities for boosting biocatalytic disinfection, Journal of Colloid and Interface Science, 2024, 661: 520-532.

7. Duanping Sun*, Fayin Mo, Yingxin Zhou, Jing Lu*; Heng Duan*, One-pot assembly of Au nanoparticles in different dimensional MOFs with peroxidase-like activity for enhanced bacterial eradication, Materials & Design, 2024, 239: 112804.

8. Maoqiang Wu, Junjie Hu, Duanping Sun, Jing Lu*, Heng Duan*, Peng Duan*, Electrodeposition of gold-platinum nanoparticles on 2D M-TCPP (M=Co, Cu, Zn) for electrochemical monitoring of H2O2 from living cells, Microchemical Journal, 2024, 196: 109622.

2023

9. Wenjing Yu, Yuehuai Hu, Zhiping Liu, Kaiteng Guo, Dinghu Ma, Mingxia Peng, Yuemei Wang, Jing Zhang, Xiaolei Zhang, Panxia Wang, Jiguo Zhang, Peiqing Liu*, Jing Lu*, Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis, Acta Pharmaceutica Sinica B, 2023, 13(12): 4875-4892. (IF: 14.7)

10. Lizhu Zeng, Chenjia Lin, Peiqing Liu*, Duanping Sun*, Jing Lu*, Anisotropic aptamer-modified DNA tetrahedra/MOF nanoprobes for enhanced colorimetric aptasensing of cardiac troponin I, Chemical Engineering Journal, 2023, 474: 145525. (IF: 13.3)

11. Duanping Sun*, Linxi Chen, Lizhu Zeng, Xianhua Shi, Jing Lu*, Quasi-Cu-MOFs: highly improved water stability and electrocatalytic activity toward H2O2 reduction among pristine 3D MOFs, Journal of Materials Chemistry A, 2023, 11(1): 31-40. (IF: 10.7, Outside Front Cover)

12. Duanping Sun*, Ying Ma, Maoqiang Wu, Zuanguang Chen, Luyong Zhang*, Jing Lu*, Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles, Journal of Pharmaceutical Analysis, 2023, 13(4): 340-354.

13. Zhen Guo, Yuehuai Hu, Guoshuai Feng, Carla Valenzuela Ripoll, Zhenzhen Li, Sidong Cai, Qianqian Wang, Wenwei Luo, Qian Li, Liying Liang, Zhongkai Wu, Jiguo Zhang, Ali Javaheri, Lei Wang*, Jing Lu*, Peiqing Liu*, JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit, Acta Pharmacologica Sinica, 2023, 44: 1777-1789.

14. Xiangjun He, Zhi Zhong, Quan Wang, Zhenmao Jia, Jing Lu*, Jianwen Chen*, Peiqing Liu*, Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone, Frontiers in Pharmacology, 2023, 14: 1127219.

15. Zesen Ye, Panxia Wang, Guodong Feng, Quan Wang, Cui Liu, Jing Lu*, Jianwen Chen*, Peiqing Liu*, Cryptotanshinone attenuates LPS-induced acute lung injury by regulating metabolic reprogramming of macrophage, Frontiers in Medicine, 2023, 9: 1075465.

2022

16. Luping Wang, Panxia Wang, Suowen Xu, Zhuoming Li, Dayue Darrel Duan, Jiantao Ye, Jingyan Li, Yanqing Ding, Wenqing Zhang, Jing Lu*, Peiqing Liu*, The cross-talk between PARylation and SUMOylation in C/EBPβ at K134 site participates in pathological cardiac hypertrophy, International Journal of Biological Sciences, 2022, 18(2): 783-799.

17. Chuyan Lin, Xiangjian Guo, Linxi Chen, Tianhui You*, Jing Lu*, Duanping Sun*, Ultrathin trimetallic metal-organic framework nanosheets for accelerating bacteria-infected wound healing, Journal of Colloid and Interface Science, 2022, 628: 731-744.

18. Yanjun Cao, Jingyan Li, Panxia Wang, Zhirong Lin, Wenjing Yu, Jiguo Zhang*, Jing Lu*, Peiqing Liu*, PKC-zeta aggravates doxorubicin-induced cardiotoxicity by inhibiting Wnt/beta-catenin signaling, Frontiers in Pharmacology, 2022, 13: 798436.

2021

19. Jing Lu, Suowen Xu, Yuqing Huo, Duanping Sun, Yuehuai Hu, Junjian Wang, Xiaolei Zhang, Panxia Wang, Zhuoming Li, Mengya Liang, Zhongkai Wu*, Peiqing Liu*, Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3, Cell Death and Differentiation, 2021, 28(10): 2871-2887. (IF: 13.7, CDDpress: Monthly Readers' Choice)

20. Siyi Chen, Jing Lu*, Tianhui You*, Duanping Sun*, Metal-organic frameworks for improving wound healing, Coordination Chemistry Reviews, 2021, 439: 213929. (IF: 20.3)

21. Panxia Wang, Minghui Wang, Yuehuai Hu, Jianxing Chen, Yanjun Cao, Cui Liu, Zhongkai Wu, Juan Shen*, Jing Lu*; Peiqing Liu*, Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, Acta Pharmaceutica Sinica B, 2021, 11(3): 680-693. (IF: 14.7)

2020

22. Duanping Sun*, Dingcao Yang, Ping Wei, Bing Liu, Zuanguang Chen, Luyong Zhang*, Jing Lu*, One-step electrodeposition of silver nanostructures on 2D/3D metal-organic framework ZIF-67: Comparison and application in electrochemical detection of hydrogen peroxide, ACS Applied Materials & Interfaces, 2020, 12(37): 41960-41968.

23. Jing Lu, Yuehuai Hu, Panxia Wang, Peiqing Liu, Zuanguang Chen, Duanping Sun*, Electrochemical biosensor based on gold nanoflowers-encapsulated magnetic metal-organic framework nanozymes for drug evaluation with in-situ monitoring of H2O2 released from H9C2 cardiac cells, Sensors and Actuators B-Chemical, 2020, 311: 127909.

24. Panxia Wang, Rui Lan, Zhen Guo, Sidong Cai, Junjian Wang, Quan Wang, Zeyu Li, Zhenzhen Li, Qianqian Wang, Jingyan Li, Zhongkai Wu, Jing Lu*, Peiqing Liu*, Histone demethylase JMJD3 mediated doxorubicin-induced cardiomyopathy by suppressing SESN2 expression, Frontiers in Cell and Developmental Biology, 2020, 8: 548605.

參編教材

1.《實驗藥理學》第二十一章心血管系統疾病的實驗藥理學研究,高等教育出版社,20213月出版,參編

2.《高等藥理學》第三十章心力衰竭治療藥物,科學出版社,20197月出版,參編

3.《心腦血管藥理學》第十七章治療心力衰竭的藥物,科學出版社,20193月出版,參編