陸明，博士，副教授。2007年畢業于中山大學，高分子物理與化學專業，獲博士學位，留校從事藥劑學研究。2015-2016年赴美國普渡大學太阳集团1088vipDr. Lynne S. Taylor課題組進行合作研究。研究興趣為熱熔擠出制劑技術、藥物過飽和溶液的相行為和藥物固态化學研究。研究成果主要發表在Angewandte Chemie, Chemical Communications, Communications Chemistry, Crystal Growth&Design, International Journal of Pharmaceutics, Pharmaceutical Research等藥劑學、化學和晶體學主流期刊上。擔任上述期刊審稿人，任中國晶體學會藥物晶體學專業委員會理事。

 

ORCID:  https://orcid.org/0000-0002-2622-1528

 

ResearchGate:  https://www.researchgate.net/profile/Ming_Lu26

 

Google Scholar: https://scholar.google.com/citations?user=Cl0aa6IAAAAJ&hl=en

 

 

1. Ming Lu. Chapter 9. Novel excipients and materials used in 3D printing of pharmaceutical dosage forms. 3D and 4D printing in biomedical applications: Process engineering and additive manufacturing. Editor: Mohammed Maniruzzaman. Publisher: John Wiley, UK, 2019.

 

2. Ming Lu. Chapter 10: Continuous cocrystallization of poorly soluble APIs to enhance dissolution. Practical guide to hot-melt extrusion: continuous manufacturing and scale-up methodologies. Editor: Mohammed Maniruzzaman. Publisher: SmithersRapra, UK, 2015.

 

代表性論文

1. Molly Lightowler⁺, Shuting Li⁺, Xiao Ou, Jungyoun Cho, Ao Li, Gerhard Hofer, Jiaoyan Xu, Taimin Yang, Xiaodong Zou, Ming Lu^*, Hongyi Xu^*. Phase identification and discovery of an elusive polymorph of drug-polymer inclusion complex using automated 3D electron diffraction. Angewandte Chemie International Edition, 2024, e202317695. https://doi.org/10.1002/anie.202317695.

2. Binbin Liu⁺, Changrui Li⁺, Ziqiao Chena, Xiao Oua, Shuting Lia, Ao Lia, Pin Chen*, Ming Lu*.Molecular insights into the formation of drug-polymer inclusion complex. International Journal of Pharmaceutics, 2024, 652(5): 123761. https://doi.org/10.1016/j.ijpharm.2023.123761

 

3. Shuting Li, Binbin Liu, Xiao Ou, Haowei Rong, Ming Lu*. Ritonavir revisited: Melt crystallization can easily find the late appearing polymorph II and unexpectedly discover a new polymorph III. Molecular Pharmaceutics, 2023, 20, 8: 3854–3863. https://doi.org/10.1021/acs.molpharmaceut.2c00994

 

4. Shuting Li,⁺ Molly Lightowler,⁺ Xiao Ou, Siyong Huang, Yifan Jiang, Xizhen Li,  Xiaodong Zou, Hongyi Xu,^* Ming Lu^*. Polymorphism of vemurafenib: Direct structure determination from spherulites using 3D electron diffraction. Communications Chemistry, 2023, 6:18. https://doi.org/10.1038/s42004-022-00804-2

 

5. Ao Li, Shuting Li, Jiashu Wang, Yunyun Chen, Ming Lu*. Pterostilbene-nicotinamide cocrystal: A case reported of single crystals grown from melt micro droplets. Crystal Growth & Design, 2023, 23(1): 6-10. https://doi.org/10.1021/acs.cgd.2c01073

 

6. Xiao Ou,⁺ Shuting Li,⁺ Yunyun Chen, Haowei Rong, Ao Li, Ming Lu*. Polymorphism in griseofulvin: New story between an old drug and polyethylene glycol. Crystal Growth & Design, 2022, 22, 6: 3778-3785. https://doi.org/10.1021/acs.cgd.2c00156 (Highlighted as the outside front cover)

 

7. Molly Lightowler,⁺ Shuting Li,⁺ Xiao Ou, Xiaodong Zou, Ming Lu,^* Hongyi Xu.^* Indomethacin polymorph δ revealed to be two plastically bendable crystal forms by 3D electron diffraction: Correcting a 47-year-old misunderstanding. Angewandte Chemie International Edition, 2022, 61(7): e202114985, https://doi.org/10.33774/chemrxiv-2021-s9fhf (Highlighted as the outside front cover)

 

8. Huanyue Zhou, Yu Wang, Shuting Li, Ming Lu.* Improving chemical stability of resveratrol in hot melt extrusion based on formation of eutectic with nicotinamide. International Journal of Pharmaceutics, 2021, 607: 121042. https://doi.org/10.1016/j.ijpharm.2021.121042

 

9. Xizhen Li,⁺ Xiao Ou,⁺ Bingquan Wang,⁺ Haowei Rong, Bing Wang, Chao Chang, Baimei Shi, Lian Yu, Ming Lu*. Rich polymorph in nicotinamide revealed by melt crystallization and crystal structure prediction. Communications Chemistry, 2020, 3, 152. https://doi.org/10.1038/s42004-020-00401-1

 

 

10. Xizhen Li, Xiao Ou, Haowei Rong, Siyong Huang, Jonas Nyman, Lian Yu, Ming Lu.* The twelfth solved structure of ROY: Single crystals of Y04 grown from melt microdroplets. Crystal Growth & Design. 2020, 20(11): 7093-7097. https://doi.org/10.1021/acs.cgd.0c01017 (Highlighted as the outside front cover)

 

 

11. Xiao Ou,⁺ XizhenLi,⁺ Haowei Rong, Lian Yu, Ming Lu*. A general method for cultivating single crystals from melt micro droplets. Chemical Communications, 2020, 56: 9950-9953. https://doi.org/10.1039/D0CC03157G

 

 

12. Deen Huang, Ziyuan Xie, Qiuhong Rao, Evangelos Liamas, Piaopiao Pan, Shixia Guan*, Zhenyu Jason Zhang, Ming Lu*, Qingguo Li*. Hot melt extrusion of heat-sensitive and high melting point drug: Inhibit the recrystallization of the prepared amorphous drug during extrusion to improve the bioavailability. International Journal of Pharmaceutics, 2019, 565: 316-324. https://doi.org/10.1016/j.ijpharm.2019.04.064

 

 

13. Zhengwei Huang, Ling Lin, Cushla McGoverin, Hu Liu, Lili Wang, Qi (Tony) Zhou, Ming Lu*, Chuanbin Wu. Dry powder inhaler formulations of poorly water-soluble itraconazole：A balance between in-vitro dissolution and in-vivo distribution is necessary. International Journal of Pharmaceutics, 2018，551(1-2): 103-110. https://doi.org/10.1016/j.ijpharm.2018.09.018

 

14. Yongcheng Li, Ming Lu*, Chuanbin Wu*. PVP VA64 as a novel release-modifier for sustained-release mini-matrices prepared via hot melt extrusion. Drug Delivery and Translation Research. 2018, 8(6): 1670-1678. https://doi.org/10.1007/s13346-017-0437-9

 

15. Ling Lin, Guilan Quan, Tingting Peng, Zhengwei Huang, Vikramjeet Singh, Ming Lu*, Chuanbin Wu*. Development of fine solid-crystal suspension with enhanced solubility, stability, and aerosolization performance for dry powder inhalation. International Journal of Pharmaceuticals. 2017, 533(1): 84-92. https://doi.org/10.1016/j.ijpharm.2017.09.024

 

16. Ming Lu, Lynne S*. Taylor. Vemurafenib: A tetramorphic system displaying concomitant crystallization from the supercooled liquid. Crystal Growth & Design, 2016, 16 (10): 6033–6042. https://doi.org/10.1021/acs.cgd.6b01066

 

17. Pin Dong, Ling Lin, Yongcheng Li, Zhengwei Huang, Tianqun Lang, Chuanbin Wu*, Ming Lu*. In-situ synchrotron wide-angle X-ray diffraction as a rapid method for cocrystal/salt screening. International Journal of Pharmaceutics. 2015, 496(1): 107-116. https://doi.org/10.1016/j.ijpharm.2015.03.045

 

18. Ming Lu, Zhefei Guo, Yongcheng Li, Huishi Pang, Ling Lin, Xin Pan*, Chuanbin Wu*. Application of hot melt extrusion for poorly water-soluble drugs: Limitations, Advances and Future prospects. Current Pharmaceutical Design. 2014, 20(3):369-387. http://doi.org/10.2174/13816128113199990402

 

19.  Zhefei Guo, Ming Lu*, Yongcheng Li, Huishi Pang, Ling Lin, Xu Liu, Chuanbin Wu*. The utilization of drug-polymer interactions for improving the chemical stability of hot-melt extruded solid dispersions. Journal of Pharmacy and Pharmacology. 2014, 66(2): 285-296. https://doi.org/10.1111/jphp.12145

 

20. Yongcheng Li, Huishi Pang, Zhefei Guo, Ling Lin, Yixuan Dong, Ge Li, Ming Lu*, Chuanbin Wu. Interactions between drugs and polymers influencing hot melt extrusion. Journal of Pharmacy and Pharmacology. 2014, 66(2): 148-166. https://doi.org/10.1111/jphp.12183

 

21. Xu Liu, Ming Lu*, Zhe fei Guo, Lin Huang, Xin Feng, Chuanbin Wu*. Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion. Pharmaceutical Research. 2012, 29(3): 806-817. https://doi.org/10.1007/s11095-011-0605-4

 

(⁺ Equal contribution, * Corresponding author)

 

授權專利

 

1. 陸明，李錫祯，歐霄。化合物單晶及其制備方法。專利号：CN112239890B。（授權日期：2022年6月21日）

2. 陸明，黃思詠，李錫祯，歐霄。化合物單晶及其制備方法。專利号：CN112250663B。（授權日期：2022年8月19日）

3. 吳傳斌，董品，陸明。 伊曲康唑的固體分散體制備方法和應用。專利号：201510460617.6。(授權日期：2018年2月5日)

4. 吳傳斌，林玲，陸明。伊曲康唑吸入粉霧劑及其制備方法。專利号：CN 104398497B。（授權日期：2017年11月24日）

5. 吳傳斌，陸明，黎永誠。富馬酸喹硫平緩釋制劑及其制備方法。專利号：ZL201410232678.2。（授權日期：2017年10月3日）

6. 吳傳斌，陸明，郭喆霏。二氟尼柳固體分散體及其制備方法。專利号：CN 103202811A。（授權日期：2015年4月15日）

7. 吳傳斌，劉旭，陸明。一種難溶性藥物共晶固體分散體及其制備方法。專利号：CN 102188365 B。（授權日期：2012年12月5日）

 

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