2025年招收專碩2名，歡迎報考，聯系方式lsshsl@mail.sysu.edu.cn
簡單介紹
黃世亮，1973年，博士，博導，副教授。1995年于沈陽藥科大學獲得化學制藥專業學士學位，并于1998年獲該校藥物化學碩士學位，2006年于中山大學獲有機化學博士學位。1998年在中山大學任教至今。2010-2011年國家公派英國諾丁漢大學太阳集团1088vip訪問學者。
科研項目
1）熱休克轉錄因子HSF1選擇性抑制劑的設計、合成及抗腫瘤作用機制研究，國家自然科學基金面上項目（82073680），2021.1-2024.12
2) 以阿的平為先導化合物的Hsp90/Topo II雙靶點抑制劑的結構改造、活性篩選與機制研究（2021A1515010554），2021.1-2023.12
3) 選擇性靶向Top IIa的ATPase的新型抗腫瘤曼宋酮類化合物的設計、合成及機制研究(21272288/B020601),國家自然科學基金，2013.1-2016.12.
4）基于FP和TR-FRET高通量篩選技術：靶向Top IIa ATPase新先導物的發現及結構改造（2015A030313120）,省自然科學基金面上項目，2014年10月至 2017年9月
5）選擇性靶向Top IIα的ATPase的新型抗腫瘤曼宋酮類化合物的設計、合成及機制研究(21272288), 國家自然科學基金，2013.1-2016.12.
6） 靶向TopIIα ATPase位點的新型曼宋酮類化合物的設計、合成及機制研究,藥用資源化學與藥物分子工程教育部重點實驗室資助課題（CMEMR2012-B02）, 2012.6-2015.5
論著專利
1) Xu, S. M.; Wang, L.; Liu, X. Z.; Huang, W. H.; Hu, Y. T.; Chen, S. B.; Huang, Z. S.*; Huang, S. L*. Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy. Biochim Biophys Acta Mol Basis Dis 2024, 167630
2) Ou, J. B.; Huang, W. H.; Liu, X. Z.; Dai, G. Y.; Wang, L.; Huang, Z. S.; Huang, S. L.* MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II. Molecules 2023, 28(14), 5598-5605.
3) Pan, X.; Mao, T.-y.; Mai, Y.-w.; Liang, C.-c.; Huang, W.-h.; Rao, Y.; Huang, Z.-s.; Huang, S.-l.* Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy. Molecules 2022, 27.5561-5577.
4) Mai, Y.-W.; Liang, C.-C.; Ou, J.-B.; Xie, H.-T.; Chen, S.-B.; Zhou, D.-C.; Yao, P.-F.; Huang, Z.-S.; Wang, H.; Huang, S.-L.* 9-Bromo-2,3-diethylbenzo[de]chromene-7,8-dione (MSN54): A novel non-intercalative topoisomerase II catalytic inhibitor. Bioorganic Chemistry 2021, 114.105097
5) Zhou, M.; Wang, X.; Xia, J.; Cheng, Y.; Xiao, L.; Bei, Y.; Tang, J.; Huang, Y.; Xiang, Q.*; Huang, S.* A Mansonone Derivative Coupled with Monoclonal Antibody 4D5-Modified Chitosan Inhibit AKR1C3 to Treat Castration-Resistant Prostate Cancer. Int J Nanomedicine 2020, 15, 3087-3098.
6) Zhou, D. C.; Lu, Y. T.; Mai, Y. W.; Zhang, C.; Xia, J.; Yao, P. F.; Wang, H. G.; Huang, S. L.*; Huang, Z. S.*，Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors. Bioorg Chem 2019, 91, 103131.
7) Peng Lv, Chun-Li Xia, Ning Wang, Zhen-Quan Liu, Zhi-Shu Huang, Shi-Liang Huang. Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. Bioorg Med Chem, 2018, 26(16), 4693-4705
8）Xie, H.-T.; Zhou, D.-C.; Mai, Y.-W.; Huo, L.; Yao, P.-F.; Huang, S.-L.*; Wang, H.-G.; Huang, Z.-S.; Gu, L.-Q. Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities. RSC Adv. 2017, 7, 20919-20928.
9）Li, P. H.; Zeng, P.; Chen, S. B.; Yao, P. F.; Mai, Y. W.; Tan, J. H.; Ou, T. M.; Huang, S. L.*; Li, D.; Gu, L. Q.; Huang, Z. S.*Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors. J Med. Chem. 2016, 59, 238-52.
10）Zhai, P.; Xia, C. L.; Tan, J. H.; Li, D.; Ou, T. M.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Syntheses and evaluation of asymmetric curcumin analogues as potential multifunctional agents for the treatment of Alzheimer's disease. Current Alzheimer research 2015, 12, 403-14.
11） Yao, B. L.; Mai, Y. W.; Chen, S. B.; Xie, H. T.; Yao, P. F.; Ou, T. M.; Tan, J. H.; Wang, H. G.; Li, D.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors. Eur. J. Med. Chem. 2015, 92, 540-53.
12）Zhuo, S. T., Li, C. Y., Hu, M. H., Chen, S. B., Yao, P. F., Huang, S. L.,* Ou, T. M., Tan, J. H., An, L. K., Li, D., Gu, L. Q., and Huang, Z. S.* Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II, Org. Biomol. Chem. 2013,11(24), 3989-4005.
13) Huang, Z. H., Zhuo, S. T., Li, C. Y., Xie, H. T., Li, D., Tan, J. H., Ou, T. M., Huang, Z. S., Gu, L. Q., and Huang, S. L.* Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors, Eur. J. Med. Chem. 2013,68C, 58-71.
14) Chen, Y. P., Zhang, Z. Y., Li, Y. P., Li, D., Huang, S. L.,* Gu, L. Q., Xu, J., and Huang, Z. S. () Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase, Eur. J. Med. Chem. 2013, 66, 22-31.
15) Li, Y. P., Weng, X., Ning, F. X., Ou, J. B., Hou, J. Q., Luo, H. B.,* Li, D., Huang, Z. S., Huang, S. L.,* and Gu, L. Q. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method, J. Mol. Graph. Model. 2013, 41, 61-67.
16) Li, Y.-P., Ning, F.-X., Yang, M.-B., Li, Y.-C., Nie, M.-H., Ou, T.-M., Tan, J.-H., Huang, S.-L.,* Li, D., Gu, L.-Q., Huang, Z.-S. Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur. J. Med. Chem., 2011. 46(5): 1572-1581
17) Fang Xian Ning, Xiang Weng, Shi Liang Huang,* Li Jun Gu, Zhi Shu Huang, * Lian Quan Gu.A facile and efficient method for hydroxylation of azabenzanthrone compounds.Chin. Chem. Lett. 2011,22(1), 41-44
18) Wei-bin Wu, Jie-bin Ou, Zhi-shu Huang, Shuo-bin Chen, Tian-miao Ou, Jia-heng. Tan, Ding Li, Liu-lan. Shen, Shi-liang Huang*, Lian-quan Gu and Zhi-shu Huang, Eur. J. Med. Chem. 2011, 46, 3339-3347.
19) Zhong Liu, Shi-Liang Huang, Man-Mei Li, Zhi-Shu Huang, Kin Sing Lee*, Lian-Quan Gu*. Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity. Chem-Bio. Interac. 2009, 177(1), 48-57
20) Hua-pei Jian, Xing-yuan Wang, Zhi-shu Huang, Shi-liang Huang,*, Lian-quan Gu. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines. Heterocycles. 2008,75(7),1773-1778.