藥學前沿大講堂第255講

題    目：Orbitides as molecular Lego（可以作為分子磚塊的環肽）

報告人：Martin JT Reaney教授，美國北卡羅來納州立大學植物與微生物系

主持人：楊得坡 教授，太阳集团1088vip

時    間：2016年6月18日（周六）10:00-12:00

地    點：中山大學東校區太阳集团1088vip112會議室

報告内容：

Flaxseed orbitides are RiPPs that are readily extracted from flaxseed and flaxseed oil. The structures of orbitide encoding genes indicate several mechanisms that lead to substantial orbitide accumulation. These highly active production systems can be harnessed for commercial orbitide synthesis in flaxseed or through a modified organism. Ribosomal synthesis of small cyclic peptides would be an environmentally friendly alternative to chemical synthesis of these precursor proteins. The Canadian flaxseed crop contains over 700 tonnes of recoverable orbitide. Orbitides are robust molecules that may be modified through chemical reactions to produce a wide range of materials. For example, covalent linkage of flaxseed orbitides to compounds, proteins and solids might be used to produce useful products and building blocks. The orbitides form a uniquely stable group of compounds that have the diversity and plasticity of proteins but, due to their small size, are stable enough for efficient and specific chemical modification. Orbitides form host-guest complexes. We have produced Forster resonance energy transfer compounds that involve orbitides linked covalently to coumarin that also hold lanthanide molecules as guests. The use of such compounds is potentially wide ranging. For example, we are exploring applications of these compounds as components of organic light emitting diodes and as environmental sensors. With improved knowledge of orbitide genetics, production, chemistry and interactions they might be developed for use as a naturally occurring “Lego” set that can be used to make almost anything.

報告人簡介：

Martin J.T. Reaney教授，1980年，1985年分别于University of British Columbia，（英屬哥倫比亞大學）本科畢業，University of Saskatchewan （薩斯喀徹溫大學）碩士畢業，1989年University of Saskatchewan （薩斯喀徹溫大學）博士畢業。現任University of Saskatchewan （薩斯喀徹溫大學）農業與生物資源學院終生教授，薩斯喀徹溫省農業部油脂質量與應用研究中心主席。Reaney教授緻力于研究用于油脂作物及其高附加價值的商業生物制品的研究生産，Reaney教授的研究範圍包括環肽化合物相關的一系列天然健康産品，藥物，化妝品等，及其此類化合物的工業化和商業化技術研究。他與加拿大農業及農産品部合作Agriculture and Agri-Food Canada (AAFC)近15年（1990-2004），發表90篇SCI文章，220次會議報告，24項美國專利（4項世界專利），多次獲得美國及加拿大頒發的創新獎項（Innovation Award）。近年他創立公司Prairie Tide Chemicals Inc，正将其團隊近年來對于加拿大廣泛種植的亞麻籽中含有的一系列化合物（環肽）的研究發現進行商業化。

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