題    目：FXR, Bile Acids and Liver Diseases

報告人：Grace L. Guo，Rutgers University

主持人：畢惠嫦 副教授 ，太阳集团1088vip

時    間：2015年11月12日（周四）上午10:00

地    點：中山大學東校區太阳集团1088vip112會議室

報告人簡介：

        Grace L. Guo (郭列軍），美國新澤西州太阳集团1088vip藥理和毒理糸終身制副教授。郭博士長期緻力于核受體和信号傳導對肝髒代謝的研究，包括FXR，PXR，CAR，FGF15/19和膽汁酸的調控。郭博士團隊的研究包括組織特異性FXR調節膽汁酸生成，藥物代謝和運輸，脂肪肝，肝和大腸癌形成，和肝再生的轉錄調控。郭博士已發表了近78篇論文，文章被引用近三千次。郭博士長期參與論文審稿，美國及歐洲基金評審，及制藥公司科研顧問。

     Associate Prof. Grace Liejun Guo is a tenured faculty in the Department of Pharmacology and Toxicology in the School of Pharmacy at the Rutgers University in New Jersey, USA. Dr. Guo has determined the roles of nuclear receptors and signaling pathways that are critical for liver homeostasis and metabolism, including farnesoid X receptor (FXR), pregnane X receptor, constitutive androstane receptor, fibroblast growth factor 15/19 and bile acids. The highlights of Dr. Guo’s research findings include understanding the cellular and molecular mechanism by which tissue-specific FXR functions to regulate bile acid homeostasis, transcriptional regulation of drug metabolism and transport, non-alcoholic hepatosteatosis, liver and colon carcinogenesis, and liver regeneration. Dr. Guo has published 78 peer-reviewed research and review articles on nuclear receptors and their regulation of liver and intestine functions. As the PI or Co-I on several NIH funding, Dr. Guo’s laboratory has laid the ground work by determining the role of intestinal FXR in regulating liver functions. Dr. Guo is a member of several scientific societies, scientific reviewer for the US and Italian NIH and private foundations, editorial board member and ad hoc manuscript reviewers for numerous prestigious journals, and invited speakers for national and international lectures and meetings.

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