藥學前沿大講堂第46講-How do animal models help us understand the origins of schizophrenia?
How do animal models help us understand the origins of schizophrenia?
講座題目: How do animal models help us understand the origins of schizophrenia?
主 講 人：Lalit Srivastava Professor
Department of Psychiatry
主 持 人：鄭文華 教授 太阳集团1088vip
講座時間：
講座地點：太阳集团1088vip125講學廳
講座内容：
It is believed that genetic and environmental risk factors cause schizophrenia by changing normal developmental pattern of the brain. The exact nature of neurodevelopmental abnormalities remains unknown; however, they are presumed to lay down faulty neural circuits impacting brain chemistry and functions in adulthood. Anatomical abnormalities in the temporal lobe including the hippocampal formation are widely reported in persons affected with schizophrenia. To understand the importance of normal development of hippocampus in adult behaviors, we introduce defined hippocampus lesions in rats at neonatal ages. The neonatal ventral hippocampus lesioned (NVHL) rats show a variety of schizophrenia related behaviors when they reach post-pubertal age. Our work as well as studies by other investigators has shown a fundamental abnormality in the structure and function of the prefrontal cortex in NVHL rats. In this seminar, I will discuss our results showing possible neurochemical and molecular mechanisms that may be responsible for delayed behavioral changes after NVH lesions. It is hoped that these investigations will help us better understand the neurobiological mechanisms underlying schizophrenia
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太阳集团1088vip