Professor Albert S. C. Chan, Principal Investigator

Albert S. C. Chan and his team focus on the synthetic methods for novel chiral drugs and pharmaceutical processes of chiral drugs.

Major research interests
(1) Synthetic methods of chiral drugs
(2) Design, synthesis and biological evaluation of chiral drugs with new structures
(3) Pharmaceutical processes of chiral drugs

Team members
The present group members include one academician of Chinese Academy of Science, three professors, one associate professor, two lecturers, and forty graduate students. Fifty students from this group have received academic degrees (23 PhD and 27 MS degrees).

Facilities
Analytic instruments: LC-IT-TOF high resolution mass spectrometer, LC-MS, GC-MS, LC, GC, MPLC, PE-341 polarimeter.
Pilot scale apparatus for drug synthesis: Glass reactors (5L – 50 L), 50 L steel autoclave, rotary evaporators (10 L -20 L), fractional distillation apparatus

Achievements
Albert S. C. Chan’s Team has been studying chiral drugs and chiral technologies for almost ten years. A series of new chiral catalysts, asymmetric catalytic reactions, and chiral drug candidates have been developed. In addition, a number of pharmaceutical processes of chiral drugs have also been developed. Seven of them were transferred to the drug companies successfully. In recent five years, the group members have undertaken 15 projects from NSFC, European Union, Ministry of Health of China, and other funding bodies. More than 90 papers have been published in the international peer-review journals. Under the supports of the university, a number of state-of-the-art equipments were installed. Guangzhou Engineering Research Center of Industrial Catalysis and Guangdong Engineering Research Center of Chiral Drugs were set up in 2006 and 2011 respectively.

Technique services
(1) Customer service for the synthesis of chemical compounds (50 mg – 500 g).
(2) Synthesis of chiral drugs and the analytic methods of enantiomers.
(3) Synthesis of chiral catalysts and asymmetric catalytic transformations.
(4) Development of pharmaceutical process.
(5) Total synthesis and structural modifications of natural products.