藥學前沿大講堂第二十一講
講座題目：Nuclear receptor-mediated gene regulation in drug metabolism, liver disease and breast cancer
主 講 人：Wen Xie MD Ph.D. Associate Professor of Pharmaceutical Sciences
主 持 人：黃民院長 太阳集团1088vip
講座時間：2008年12月11日（星期四）下午四點
講座地點：太阳集团1088vip學術報告廳（125室）
講座摘要：Nuclear receptors play an essential role in regulating the production of drug metabolizing enzymes and transporters. This regulation has broad implications in drug metabolism, drug-drug interactions, pharmacogenetics, and several important human diseases.
主講人簡介：
Education
M.D.,
Ph.D. (Cell Biology),
Postdoctoral Fellow (Nuclear Hormone Receptor), Salk Institute, 1998-2002
· Zhou J, M Febbraio, T Wada, Y Zhai, R Kuruba, S Khadem, J He, JH Lee, S Ren, S Li, RL Silverstein and
· Gong H, P Guo, Y Zhai, J Zhou, H Uppal, MJ Jarzynka, WC Song, SY Cheng and W Xie. Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor LXR. Molecular Endocrinology 21: 1781-1790, 2007
· Uppal H, SPS Saini, A Moschetta, Y Mu, J Zhou, H Gong, Y Zhai, S Ren, GK Michalopoulos, DJ Mangelsdorf and W Xie. Acivation of LXRs prevent bile acid toxicity and cholestasis in female mice. Hepatology 45:422-432, 2007
Major terms
receptors, steroid；mice, knockout ；iver diseases； bile acids and salts breast neoplasms；prostatic neoplasms；estrogens ；cytochrome p-450 enzyme system ； dna-binding proteins ；sulfotransferases ；gene expression profiling.
NIH CRISP
PXR Controlled Bile Acid Detoxification in Colon Cancer
Phase II UDP-glucuronosyltransferases by PXR
Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
News
Wen Xie, is the sole editor of "Nuclear Receptors in Drug Metabolism," a book published by Wiley in November 2008. This eleven-chapter, 330-page book is intended to provide an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development. The book was organized by Xie. In addition to Xie, other contributing authors include leading researchers in the field from the
Wen Xie, has been selected to receive the prestigious International Society for the Study of Xenobiotics (ISSX) 2008 North American New Investigator Award. ISSX is an international society that facilitates and encourages the assemblage, acquaintanceship, and the association of scientists engaged in research in Xenobiotic metabolism and in other related disciplines.