學??術??報??告－070910

報告人:  Dr. ZhongYin Zhang

    Professor and Chairman of the Department of Biochemistry 

    and Molecular Biology Indiana University

講者簡介：

Zhong-Yin Zhang received his undergraduate degree in Chemistry

 from Nankai University, China, in 1984.  He went to Purdue 

University for graduate school and earned a Ph.D. degree in 

Biochemistry in 1990.  After a brief stint at the Upjohn 

Company, he completed his postdoctoral training at the University 

of Michigan. In 1994 he became an Assistant Professor of Molecular

 Pharmacology and Biochemistry at the Albert Einstein College of

 Medicine, where he rose to the rank of Professor in 2002. He 

joined the faculty of Indiana University School of Medicine in 

2005, where he is Robert A. Harris Professor and Chairman of the

 Department of Biochemistry and Molecular Biology. Among his 

 awards and honors, Professor Zhang is the recipient of a 

 Chemistry Graduate Program (CGP) Fellow (1985), a Sinsheimer 

 Scholar (1997) and an Irma T. Hirschl Career Scientist (1999).

 Professor Zhang’s research spans the disciplines of chemistry

 and biology with an emphasis on chemical approaches to protein 

 phosphorylation and dephosphorylation; mechanistic enzymology;

 molecular recognition; and inhibitor design. Professor Zhang 

 has employed a multidisciplinary approach to investigate protein

 tyrosine phosphatases (PTP) substrate recognition, regulation,

 and reaction mechanism. Professor Zhang has also established a

 unique academic chemical genomic program to carry out 

  high-throughput screening, combinatory chemistry, and biological

 evaluation. He is developing small molecule PTP probes that 

 not only serve as powerful tools to elucidate signaling mechanisms 

 but also find use for therapeutic development. He has authored

 more than 139 publications, and he is an internationally recognized 

 authority in the field of PTPs. Professor Zhang has organized 

 and chaired several international scientific meetings on protein 

  phosphorylation and drug development, and he has served as a 

 consultant for many major pharmaceutical companies, including 

 American Home Products, Hoffmann-La Roche, Procter & Gamble, 

 and Astra Zeneca.